Universität zu Köln

Broetzmann, Paula ORCID: 0009-0008-2434-8665, Semmler, Carolin ORCID: 0000-0002-5784-0735, Jergas, Hannah ORCID: 0000-0003-3041-1583, Brandt, Gregor A. ORCID: 0000-0002-9984-2069, van der Linden, Christina ORCID: 0000-0003-2091-4638, Schedlich-Teufer, Charlotte ORCID: 0000-0002-4465-1986, Maier, Franziska ORCID: 0000-0002-9335-9594, Kalbe, Elke ORCID: 0000-0001-8603-2545, Visser-Vandewalle, Veerle ORCID: 0000-0002-5274-7929, Barbe, Michael T. ORCID: 0000-0003-1149-8054 and Baldermann, Juan Carlos ORCID: 0000-0001-5851-9268 (2025). Longitudinal Analysis of the Deep Brain Stimulation Impairment Scale for Subthalamic Nucleus Stimulation in Parkinson’s Disease. Clinical Parkinsonism & Related Disorders, 13. pp. 1-8. Elsevier. ISSN 25901125

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Abstract

[Artikel-Nr.: 100354] Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for people with Parkinson’s disease (PwP). However, some patients treated with DBS may still experience quality of life limiting impairments after surgery, e.g., concerning posture and gait, cognition, speech, apathy or impulsivity, as well as technical challenges in managing the implanted device. The Deep Brain Stimulation Impairment Scale (DBS-IS) was developed to assess these impairments, yet their postoperative development is underexplored. Methods: We retrospectively analysed changes in the DBS-IS Total Score and subscales assessed in patients at baseline, three, six and twelve months post-DBS implantation (n = 33 PwP) using linear mixed models for repeated measurements. Furthermore, we investigated device-related issues within the first year after surgery and their impact on quality of life in a larger sample (n = 99 PwP) using DBS-IS Facility Scores. Results: After surgery we observed significant improvement in the DBS-IS Total Score (β = −1.93; p = 0.005), particularly in the subscales of postural instability, gait difficulty and cognitive impairment. 43 % of patients reported device-related problems within one year after surgery. Patients with device-related problems showed significantly less improvement in quality of life (z = −2.40; p = 0.017). Exploratory post-hoc tests suggested a higher propensity for device-related complications among older individuals (z = −2.19; p = 0.029). Conclusion: The majority of impairments evaluated by the DBS-IS, such as postural instability, gait difficulty and cognitive impairments, appear amenable to STN-DBS intervention. Special attention is warranted for potential device issues, especially in older patients, to optimize patients’ quality of life outcomes.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Broetzmann, Paula UNSPECIFIED https://orcid.org/0009-0008-2434-8665 UNSPECIFIED Semmler, Carolin UNSPECIFIED https://orcid.org/0000-0002-5784-0735 UNSPECIFIED Jergas, Hannah UNSPECIFIED https://orcid.org/0000-0003-3041-1583 UNSPECIFIED Brandt, Gregor A. UNSPECIFIED https://orcid.org/0000-0002-9984-2069 UNSPECIFIED van der Linden, Christina UNSPECIFIED https://orcid.org/0000-0003-2091-4638 UNSPECIFIED Schedlich-Teufer, Charlotte UNSPECIFIED https://orcid.org/0000-0002-4465-1986 UNSPECIFIED Maier, Franziska UNSPECIFIED https://orcid.org/0000-0002-9335-9594 UNSPECIFIED Kalbe, Elke UNSPECIFIED https://orcid.org/0000-0001-8603-2545 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED https://orcid.org/0000-0002-5274-7929 UNSPECIFIED Barbe, Michael T. UNSPECIFIED https://orcid.org/0000-0003-1149-8054 UNSPECIFIED Baldermann, Juan Carlos UNSPECIFIED https://orcid.org/0000-0001-5851-9268 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-805621
Identification Number:	10.1016/j.prdoa.2025.100354
Journal or Publication Title:	Clinical Parkinsonism & Related Disorders
Volume:	13
Page Range:	pp. 1-8
Number of Pages:	8
Date:	11 June 2025
Publisher:	Elsevier
ISSN:	25901125
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Neurochirurgie > Klinik für Stereotaxie und funktionelle Neurochirurgie Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Faculty of Medicine > Psychiatrie und Psychotherapie > Klinik und Poliklinik für Psychiatrie und Psychotherapie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Deep Brain Stimulation ; DBS ; STN-DBS ; DBS-Impairment Scale ; DBS-IS ; Quality of life English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80562