Universität zu Köln

Reinhold, Ilana ORCID: 0000-0002-6222-0418, Picardi, Susanne, Liss, Blasius, Seidel, Danila ORCID: 0000-0003-4388-3117, Stemler, Jannik ORCID: 0000-0001-9152-2469, Koehler, Philipp ORCID: 0000-0002-7386-7495, Ruegamer, Tamara ORCID: 0000-0002-1535-8625, Sprute, Rosanne ORCID: 0000-0003-2457-6437 and Cornely, Oliver A ORCID: 0000-0001-9599-3137 (2026). Towards shorter therapy for candidaemia: defining uncomplicated candidaemia in adults. The Lancet Infectious Diseases, 26 (2). e112-e123. Elsevier. ISSN 1473-3099

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Abstract

Although the characteristics of complicated candidaemia are well known, uncomplicated disease remains undefined. Recommended treatment duration for candidaemia is 14 days after bloodstream infection is cleared. Longer treatment duration might be required if candidaemia is complicated by deep organ involvement or by immunocompromising conditions such as neutropenia, uncontrolled haematological malignancy, or in the context of haematopoietic stem-cell transplantation. Complicated candidaemia might further be assumed in prolonged and high-dose glucocorticosteroid exposure, candidaemia recurrence, or with echinocandin-resistant pathogens. In this Review, outcome data were analysed to identify criteria differentiating between complicated and uncomplicated candidaemia in adults. We propose defining uncomplicated candidaemia by controlled source, clinical response, and clearance of the bloodstream within 5 days of appropriate antifungal treatment. Further data are needed to support or challenge our proposed definitions. Shorter treatment courses in this population meeting the definition criteria for uncomplicated candidaemia warrant evaluation in randomised controlled clinical trials.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Reinhold, Ilana UNSPECIFIED https://orcid.org/0000-0002-6222-0418 UNSPECIFIED Picardi, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Liss, Blasius UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidel, Danila UNSPECIFIED https://orcid.org/0000-0003-4388-3117 UNSPECIFIED Stemler, Jannik UNSPECIFIED https://orcid.org/0000-0001-9152-2469 UNSPECIFIED Koehler, Philipp UNSPECIFIED https://orcid.org/0000-0002-7386-7495 UNSPECIFIED Ruegamer, Tamara UNSPECIFIED https://orcid.org/0000-0002-1535-8625 UNSPECIFIED Sprute, Rosanne UNSPECIFIED https://orcid.org/0000-0003-2457-6437 UNSPECIFIED Cornely, Oliver A UNSPECIFIED https://orcid.org/0000-0001-9599-3137 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-805927
Identification Number:	10.1016/S1473-3099(25)00409-8
Journal or Publication Title:	The Lancet Infectious Diseases
Volume:	26
Number:	2
Page Range:	e112-e123
Number of Pages:	12
Date:	February 2026
Publisher:	Elsevier
ISSN:	1473-3099
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Medizinische Mikrobiologie, Immunologie und Hygiene > Institut für Medizinische Mikrobiologie, Immunologie und Hygiene Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO) Faculty of Medicine > Weitere > Zentrum für Klinische Studien
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80592