Universität zu Köln

Li, Panpan, Shi, Xin, Liu, Hanhan, Feng, Yuan, Wang, Xiaosha, Herb, Marc, Ji, Haichao, Wagner, Stefan, Vogt, Johannes and Prokosch, Verena ORCID: 0000-0002-5318-0637 (2025). HOCPCA Exerts Neuroprotection on Retinal Ganglion Cells by Binding to CaMKIIα and Modulating Oxidative Stress and Neuroinflammation in Experimental Glaucoma. Neuroscience Bulletin, 41 (8). pp. 1329-1346. Springer Nature. ISSN 1673-7067

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Abstract

Neuronal injury in glaucoma persists despite effective intraocular pressure (IOP) control, necessitating neuroprotective strategies for retinal ganglion cells (RGCs). In this study, we investigated the neuroprotective role of the γ-hydroxybutyrate analog HOCPCA in a glaucoma model, focusing on its effects on CaMKII signaling, oxidative stress, and neuroinflammatory responses. Retinal tissue from high IOP animal models was analyzed via proteomics. In vitro mouse retinal explants were subjected to elevated pressure and oxidative stress, followed by HOCPCA treatment. HOCPCA significantly mitigated the RGC loss induced by oxidative stress and elevated pressure, preserving neuronal function. It restored CaMKIIα and β levels, preserving RGC integrity, while also modulating oxidative stress and neuroinflammatory responses. These findings suggest that HOCPCA, through its interaction with CaMKII, holds promise as a neuroprotective therapy for glaucoma.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Li, Panpan UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Xin UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Hanhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Feng, Yuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xiaosha UNSPECIFIED UNSPECIFIED UNSPECIFIED Herb, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Ji, Haichao UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogt, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokosch, Verena UNSPECIFIED https://orcid.org/0000-0002-5318-0637 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-806467
Identification Number:	10.1007/s12264-025-01417-0
Journal or Publication Title:	Neuroscience Bulletin
Volume:	41
Number:	8
Page Range:	pp. 1329-1346
Number of Pages:	18
Date:	2 August 2025
Publisher:	Springer Nature
ISSN:	1673-7067
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Augenheilkunde > Klinik und Poliklinik für Allgemeine Augenheilkunde Faculty of Medicine > Medizinische Mikrobiologie, Immunologie und Hygiene > Institut für Medizinische Mikrobiologie, Immunologie und Hygiene Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language CaMKII ; HOCPCA ; RGCs ; Glaucoma ; Neuroprotection English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80646