Universität zu Köln

Müller, Roman-Ulrich ORCID: 0000-0001-6910-0745, Guerrot, Dominique ORCID: 0000-0002-5953-5785, Chonchol, Michel, Schmitt, Roland, Uchiyama, Kiyotaka, Gansevoort, Ron T and Cornec-Le Gall, Emilie ORCID: 0000-0003-1958-4459 (2025). SGLT2 inhibition for patients with ADPKD – closing the evidence gap. Nephrology Dialysis Transplantation, 40 (12). pp. 2231-2238. Oxford University Press. ISSN 0931-0509

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Abstract

Inhibitors of the sodium-glucose cotransporter 2 (SGLT2i) were originally developed to treat diabetes mellitus but have shown important renoprotective benefits independently from blood glucose levels. SGLT2i have thus become an important addition to the therapeutic armamentarium to treat patients with chronic kidney disease. However, specific patient populations were excluded from the pivotal trials, for instance patients with very low eGFR, patients on dialysis, kidney transplant recipients, and patients with autosomal dominant polycystic kidney disease (ADPKD), the most common genetic kidney disorder. Considering the lack of potent treatment modalities in ADPKD, the use of SGLT2i in this patient population would be of major interest. However, the combination of inconclusive results from preclinical models with the lack of clinical efficacy data and potential disease-specific safety concerns currently exclude patients with ADPKD from this promising therapeutic opportunity. This results in an urgent need for adequately powered clinical trials examining SGLT2i in ADPKD. This review summarizes the current knowledge on SGLT2i in this specific patient population and outlines running and upcoming clinical trial programs in different geographic regions aiming to make SGLT2i accessible to patients with ADPKD.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Müller, Roman-Ulrich UNSPECIFIED https://orcid.org/0000-0001-6910-0745 UNSPECIFIED Guerrot, Dominique UNSPECIFIED https://orcid.org/0000-0002-5953-5785 UNSPECIFIED Chonchol, Michel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitt, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Uchiyama, Kiyotaka UNSPECIFIED UNSPECIFIED UNSPECIFIED Gansevoort, Ron T UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornec-Le Gall, Emilie UNSPECIFIED https://orcid.org/0000-0003-1958-4459 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-811326
Identification Number:	10.1093/ndt/gfaf061
Journal or Publication Title:	Nephrology Dialysis Transplantation
Volume:	40
Number:	12
Page Range:	pp. 2231-2238
Number of Pages:	8
Date:	December 2025
Publisher:	Oxford University Press
ISSN:	0931-0509
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Innere Medizin > Klinik II für Innere Medizin - Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin Faculty of Medicine > Weitere > Zentrum für seltene Erkrankungen
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language ADPKD ; dapagliflozin ; empagliflozin ; polycystic kidney disease ; SGLT2i English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81132