Universität zu Köln

Szymura, Annika, Ilyas, Shaista ORCID: 0000-0002-6564-0696, Grohmann, Florian and Mathur, Sanjay ORCID: 0000-0003-2765-2693 (2025). Ionic liquid modified mesoporous silica nanocarriers for efficient drug delivery and hydrophobic surface engineering. Materials Advances, 6 (13). pp. 4220-4232. Royal Society of Chemistry. ISSN 2633-5409

PDF d4ma01267d.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (2MB)

Abstract

Attaining covalent attachment of diverse molecules onto carrier surfaces without compromising their chemical identity and biological functionality remains a challenge. Here, a newly synthesized alkyne-functionalized ionic liquid, 1-hexadecyl-3-propargyl imidazolium bromide (HDPI), was chemically attached on the surface of azide-modified mesoporous silica nanocarriers (mSiO 2 , av. size 110 nm) based on the Menshutkin reaction and copper-catalyzed click chemistry. The HDPI-functionalized mSiO 2 nanocarriers were loaded with tetracycline (TC) to develop a dual-action drug delivery system. Time-dependent drug release studies conducted at pH 7.4 and 37 °C over 48 h revealed controlled TC release. The long alkyl chain of the surface-bound ionic liquids (ILs) facilitated bacterial cell wall penetration, enhancing TC transport into both Gram-positive and Gram-negative bacteria. This dual-action mechanism was validated through antibacterial assays demonstrating that the surfactant-like IL disrupts bacterial cytoplasmic membranes, while the antibiotic induces cell death. Given the inherent antibacterial properties of ILs, we further investigated their ability to form stable, hydrophobic, and antimicrobial coatings on glass substrates under different environmental conditions. The results indicate that these IL-based coatings are uniform, durable, and hold significant potential for applications in healthcare and industry.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Szymura, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Ilyas, Shaista UNSPECIFIED https://orcid.org/0000-0002-6564-0696 UNSPECIFIED Grohmann, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED https://orcid.org/0000-0003-2765-2693 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-811576
Identification Number:	10.1039/D4MA01267D
Journal or Publication Title:	Materials Advances
Volume:	6
Number:	13
Page Range:	pp. 4220-4232
Number of Pages:	13
Date:	2025
Publisher:	Royal Society of Chemistry
ISSN:	2633-5409
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	Chemistry and allied sciences Life sciences
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81157