Universität zu Köln

Cukoski, Sadrija ORCID: 0000-0002-6427-177X, Brehm, Thomas Theo, Büttner, Stefan, Van Praet, Jens, Dolff, Sebastian, Eberwein, Lukas, Falces-Romero, Iker, Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Wanken, Manuel, Müller, Roman-Ulrich ORCID: 0000-0001-6910-0745, Burst, Volker ORCID: 0000-0002-0256-6628 and Koehler, Felix C. ORCID: 0000-0001-9269-7420 (2025). Design and set-up of the leptospirosis registry LeptoScope for epidemiology, outbreaks and clinical studies on human leptospirosis. Frontiers in Public Health, 13. Frontiers Media. ISSN 2296-2565

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Abstract

Objective: Human leptospirosis is a widespread zoonosis with endemic appearance in different parts of the world. Despite causing more than 1 million cases, nearly 60.000 deaths and 3 million disability-adjusted life-years per year, leptospirosis remains an underrecognized and neglected disease calling for multinational surveillance and international collaboration. Methods: The leptospirosis registry LeptoScope is a novel project enabling both international and multi-disciplinary research on Leptospira-caused diseases. LeptoScope has an electronic case report form and can be assessed on the General Data Protection Regulation compliant platform clinicalsurveys.net. Due to its modular structure, LeptoScope depicts or hides items according to the documented case (e.g., patients treated in outpatient setting versus patient admitted to the intensive care unit). This ensures rapid, but standardized enrolment of patients even in epidemics. Results: Information collected in LeptoScope include demographics, pre-existing diseases, clinical presentation and measures in addition to outcome. A multinational research team from Germany, Belgium and Spain contributed a pilot cohort of 78 cases with Leptospira-associated diseases to confirm LeptoScope’s functionality and practicality. Conclusion: LeptoScope is to our knowledge the first worldwide research platform on public health and clinical studies concerning Leptospira-associated diseases. LeptoScope promotes the needed collaboration at the cross-roads of public health, microbiology, infectious diseases and nephrology for an underrecognized and often neglected disease. Ensuring controlled or uncontrolled level II evidence LeptoScope may improve patient care and may provide evidence for robust treatment recommendations in future.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Cukoski, Sadrija UNSPECIFIED https://orcid.org/0000-0002-6427-177X UNSPECIFIED Brehm, Thomas Theo UNSPECIFIED UNSPECIFIED UNSPECIFIED Büttner, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Praet, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolff, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Eberwein, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Falces-Romero, Iker UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED https://orcid.org/0000-0001-9599-3137 UNSPECIFIED Wanken, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Müller, Roman-Ulrich UNSPECIFIED https://orcid.org/0000-0001-6910-0745 UNSPECIFIED Burst, Volker UNSPECIFIED https://orcid.org/0000-0002-0256-6628 UNSPECIFIED Koehler, Felix C. UNSPECIFIED https://orcid.org/0000-0001-9269-7420 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812199
Identification Number:	10.3389/fpubh.2025.1687249
Journal or Publication Title:	Frontiers in Public Health
Volume:	13
Number of Pages:	7
Date:	24 November 2025
Publisher:	Frontiers Media
ISSN:	2296-2565
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Chirurgie > Abteilung Unfallchirurgie (Klinik und Poliklinik für Orthopädie und Unfallchirurgie) Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Innere Medizin > Klinik II für Innere Medizin - Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin Faculty of Medicine > Weitere > Zentrum für Klinische Studien Faculty of Medicine > Weitere > Zentrum für seltene Erkrankungen Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language leptospirosis ; Weil’s disease ; zoonosis ; waterborne bacterial disease ; neglected tropicaldisease ; public health ; outbreak ; registry English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81219