Universität zu Köln

von Stein, Jennifer ORCID: 0009-0000-3871-164X, von Stein, Philipp ORCID: 0000-0003-4548-3897, Pfister, Roman ORCID: 0000-0002-4358-5008, Kresoja, Karl-Patrik ORCID: 0000-0002-8616-6751, Fortmeier, Vera, Koell, Benedikt, Rottbauer, Wolfgang, Kassar, Mohammad ORCID: 0000-0002-7576-2224, Goebel, Bjoern, Denti, Paolo, Achouh, Paul, Rassaf, Tienush, Barreiro-Perez, Manuel, Boekstegers, Peter, Rück, Andreas ORCID: 0000-0003-2920-6574, Zdanyte, Monika, Adamo, Marianna, Vincent, Flavien, Schlegel, Philipp, Rosch, Sebastian, Wild, Mirjam G., Besler, Christian ORCID: 0000-0002-8082-6472, Toggweiler, Stefan, Brunner, Stephanie ORCID: 0000-0001-7510-7062, Grapsa, Julia ORCID: 0000-0003-4620-6234, Patterson, Tiffany, Thiele, Holger ORCID: 0000-0002-0169-998X, Kister, Tobias, Tarantini, Giuseppe, Masiero, Giulia, De Carlo, Marco ORCID: 0000-0002-5763-9804, Sticchi, Alessandro ORCID: 0000-0001-6421-1120, Voss, Fabian, Polzin, Amin, Rubbio, Antonio P., Bedogni, Francesco, Stolte, Thorald, Nestelberger, Thomas, Benito González, Tomás, Konstandin, Mathias H., Van Belle, Eric, Metra, Marco ORCID: 0000-0001-6691-8568, Geisler, Tobias, Estévez-Loureiro, Rodrigo, Mahabadi, Amir A. ORCID: 0000-0003-2336-7991, Karam, Nicole, Maisano, Francesco, Lauten, Philipp ORCID: 0000-0001-9997-9201, Praz, Fabien ORCID: 0000-0001-5416-165X, Kessler, Mirjam, Kalbacher, Daniel ORCID: 0000-0002-2269-2461, Rudolph, Volker ORCID: 0000-0001-5385-6839, Lurz, Philipp, Granada, Juan F., Hausleiter, Jörg, Stolz, Lukas ORCID: 0000-0002-1362-1493 and Iliadis, Christos ORCID: 0000-0001-7655-8500 (2025). Tricuspid Valve Transcatheter Edge-to-Edge Repair in Patients With Cardiac Implantable Electronic Devices. Insights From EuroTR. JACC: Cardiovascular Interventions, 18 (23). pp. 2878-2891. Elsevier. ISSN 1936-8798

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Abstract

Background: Tricuspid valve transcatheter edge-to-edge repair (T-TEER) is increasingly used in patients with severe tricuspid regurgitation (TR) at high surgical risk. Long-term outcomes in those with transvalvular cardiac implantable electronic devices (CIEDs) remain insufficiently characterized. Objectives: The aim of this study was to evaluate procedural and clinical outcomes of T-TEER in patients with CIED leads in a real-world cohort. Methods: Among 3,025 patients undergoing T-TEER at 26 centers (2016-2024), 851 (28.1%) had transvalvular CIED leads. Residual TR at discharge and follow-up and the composite of all-cause mortality or heart failure hospitalization at 2 years were assessed. CIED function was evaluated preprocedure and postprocedure. Propensity score matching (1:1) was conducted to compare outcomes between patients with and those without CIEDs. Results: CIED function remained stable, and no lead revision was required. At discharge, TR ≤1+ and ≤2+ was achieved in 39.9% and 79.8%, respectively; at follow-up (median 269 days; Q1-Q3: 63-423 days), TR ≤1+ and ≤2+ persisted in 29.3% and 69.1%. In 385 matched pairs, residual TR, functional status, and 2-year heart failure hospitalization–free survival were comparable between patients with and those without CIEDs (67.1% [95% CI: 62.1%-72.5%] vs 73.6% [95% CI: 68.9%-78.6%]; P = 0.176). CIED presence showed a nonsignificant association with more adverse outcomes (HR: 1.31; 95% CI: 0.99-1.74; P = 0.063) but was not associated with residual TR >2+ (OR: 0.98; 95% CI: 0.70-1.38; P = 0.915). Achieving residual TR ≤2+ conferred significantly better survival irrespective of CIED presence (P < 0.001). Conclusions: T-TEER is safe and effective in selected patients with transvalvular CIED leads. Effective TR reduction remains prognostically relevant, even in this high-risk real-world population.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code von Stein, Jennifer UNSPECIFIED https://orcid.org/0009-0000-3871-164X UNSPECIFIED von Stein, Philipp UNSPECIFIED https://orcid.org/0000-0003-4548-3897 UNSPECIFIED Pfister, Roman UNSPECIFIED https://orcid.org/0000-0002-4358-5008 UNSPECIFIED Kresoja, Karl-Patrik UNSPECIFIED https://orcid.org/0000-0002-8616-6751 UNSPECIFIED Fortmeier, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Koell, Benedikt UNSPECIFIED UNSPECIFIED UNSPECIFIED Rottbauer, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassar, Mohammad UNSPECIFIED https://orcid.org/0000-0002-7576-2224 UNSPECIFIED Goebel, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Denti, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Achouh, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Rassaf, Tienush UNSPECIFIED UNSPECIFIED UNSPECIFIED Barreiro-Perez, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Boekstegers, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Rück, Andreas UNSPECIFIED https://orcid.org/0000-0003-2920-6574 UNSPECIFIED Zdanyte, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Adamo, Marianna UNSPECIFIED UNSPECIFIED UNSPECIFIED Vincent, Flavien UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlegel, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosch, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wild, Mirjam G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Besler, Christian UNSPECIFIED https://orcid.org/0000-0002-8082-6472 UNSPECIFIED Toggweiler, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Brunner, Stephanie UNSPECIFIED https://orcid.org/0000-0001-7510-7062 UNSPECIFIED Grapsa, Julia UNSPECIFIED https://orcid.org/0000-0003-4620-6234 UNSPECIFIED Patterson, Tiffany UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Holger UNSPECIFIED https://orcid.org/0000-0002-0169-998X UNSPECIFIED Kister, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Tarantini, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Masiero, Giulia UNSPECIFIED UNSPECIFIED UNSPECIFIED De Carlo, Marco UNSPECIFIED https://orcid.org/0000-0002-5763-9804 UNSPECIFIED Sticchi, Alessandro UNSPECIFIED https://orcid.org/0000-0001-6421-1120 UNSPECIFIED Voss, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Polzin, Amin UNSPECIFIED UNSPECIFIED UNSPECIFIED Rubbio, Antonio P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bedogni, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Stolte, Thorald UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestelberger, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Benito González, Tomás UNSPECIFIED UNSPECIFIED UNSPECIFIED Konstandin, Mathias H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Belle, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Metra, Marco UNSPECIFIED https://orcid.org/0000-0001-6691-8568 UNSPECIFIED Geisler, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Estévez-Loureiro, Rodrigo UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahabadi, Amir A. UNSPECIFIED https://orcid.org/0000-0003-2336-7991 UNSPECIFIED Karam, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Maisano, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Lauten, Philipp UNSPECIFIED https://orcid.org/0000-0001-9997-9201 UNSPECIFIED Praz, Fabien UNSPECIFIED https://orcid.org/0000-0001-5416-165X UNSPECIFIED Kessler, Mirjam UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbacher, Daniel UNSPECIFIED https://orcid.org/0000-0002-2269-2461 UNSPECIFIED Rudolph, Volker UNSPECIFIED https://orcid.org/0000-0001-5385-6839 UNSPECIFIED Lurz, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Granada, Juan F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hausleiter, Jörg UNSPECIFIED UNSPECIFIED UNSPECIFIED Stolz, Lukas UNSPECIFIED https://orcid.org/0000-0002-1362-1493 UNSPECIFIED Iliadis, Christos UNSPECIFIED https://orcid.org/0000-0001-7655-8500 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-812632
Identification Number:	10.1016/j.jcin.2025.09.033
Journal or Publication Title:	JACC: Cardiovascular Interventions
Volume:	18
Number:	23
Page Range:	pp. 2878-2891
Number of Pages:	14
Date:	8 December 2025
Publisher:	Elsevier
ISSN:	1936-8798
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik III für Innere Medizin - Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81263