Universität zu Köln

Charmpilas, Nikolaos ORCID: 0000-0002-8893-2827, Sotiriou, Aggeliki, Axarlis, Konstantinos, Tavernarakis, Nektarios ORCID: 0000-0002-5253-1466 and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2024). Reproductive regulation of the mitochondrial stress response in Caenorhabditis elegans. Cell Reports, 43 (6). pp. 1-17. Elsevier. ISSN 2211-1247

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Abstract

[Artikel-Nr.: 114336] Proteome integrity is fundamental for cellular and organismal homeostasis. The mitochondrial unfolded pro- tein response (UPRmt), a key component of the proteostasis network, is activated in a non-cell-autonomous manner in response to mitochondrial stress in distal tissues. However, the importance of inter-tissue commu- nication for UPRmt inducibility under physiological conditions remains elusive. Here, we show that an intact germline is essential for robust UPRmt induction in the Caenorhabditis elegans somatic tissues. A series of nematode mutants with germline defects are unable to respond to genetic or chemical UPRmt inducers. Our genetic analysis suggests that reproductive signals, rather than germline stem cells, are responsible for somatic UPRmt induction. Consistent with this observation, we show that UPRmt is sexually dimorphic, as male nematodes are inherently unresponsive to mitochondrial stress. Our findings highlight a paradigm of germline-somatic communication and suggest that reproductive cessation is a primary cause of age- related UPRmt decline.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Charmpilas, Nikolaos UNSPECIFIED https://orcid.org/0000-0002-8893-2827 UNSPECIFIED Sotiriou, Aggeliki UNSPECIFIED UNSPECIFIED UNSPECIFIED Axarlis, Konstantinos UNSPECIFIED UNSPECIFIED UNSPECIFIED Tavernarakis, Nektarios UNSPECIFIED https://orcid.org/0000-0002-5253-1466 UNSPECIFIED Hoppe, Thorsten UNSPECIFIED https://orcid.org/0000-0002-4734-9352 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-813763
Identification Number:	10.1016/j.celrep.2024.114336
Journal or Publication Title:	Cell Reports
Volume:	43
Number:	6
Page Range:	pp. 1-17
Number of Pages:	17
Date:	25 June 2024
Publisher:	Elsevier
ISSN:	2211-1247
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics Zentrum für Molekulare Medizin
Subjects:	Life sciences Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81376