Universität zu Köln

Torres, David E., Kramer, H. Martin, Tracanna, Vittorio ORCID: 0000-0002-7244-567X, Fiorin, Gabriel L. ORCID: 0000-0001-9706-4964, Cook, David E. ORCID: 0000-0002-2719-4701, Seidl, Michael F. ORCID: 0000-0002-5218-2083 and Thomma, Bart P. H. J. ORCID: 0000-0003-4125-4181 (2024). Implications of the three-dimensional chromatin organization for genome evolution in a fungal plant pathogen. Nature Communications, 15 (1). pp. 1-14. Springer Nature. ISSN 2041-1723

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Abstract

[Artikel-Nr.: 1701] The spatial organization of eukaryotic genomes is linked to their biological functions, although it is not clear how this impacts the overall evolution of a genome. Here, we uncover the three-dimensional (3D) genome organization of the phytopathogen Verticillium dahliae, known to possess distinct genomic regions, designated adaptive genomic regions (AGRs), enriched in transposable elements and genes that mediate host infection. Short-range DNA interactions form clear topologically associating domains (TADs) with gene-rich boundaries that show reduced levels of gene expression and reduced genomic variation. Intriguingly, TADs are less clearly insulated in AGRs than in the core genome. At a global scale, the genome contains bipartite long-range interactions, particularly enriched for AGRs and more generally containing segmental duplications. Notably, the patterns observed for V. dahliae are also present in other Verticillium species. Thus, our analysis links 3D genome organization to evolutionary features conserved throughout the Verticillium genus.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Torres, David E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kramer, H. Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Tracanna, Vittorio UNSPECIFIED https://orcid.org/0000-0002-7244-567X UNSPECIFIED Fiorin, Gabriel L. UNSPECIFIED https://orcid.org/0000-0001-9706-4964 UNSPECIFIED Cook, David E. UNSPECIFIED https://orcid.org/0000-0002-2719-4701 UNSPECIFIED Seidl, Michael F. UNSPECIFIED https://orcid.org/0000-0002-5218-2083 UNSPECIFIED Thomma, Bart P. H. J. UNSPECIFIED https://orcid.org/0000-0003-4125-4181 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-814662
Identification Number:	10.1038/s41467-024-45884-x
Journal or Publication Title:	Nature Communications
Volume:	15
Number:	1
Page Range:	pp. 1-14
Number of Pages:	14
Date:	24 February 2024
Publisher:	Springer Nature
ISSN:	2041-1723
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	CEPLAS - Cluster of Excellence on Plant Sciences
Subjects:	Life sciences
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81466