Universität zu Köln

Hadrian, Karina ORCID: 0000-0001-9713-1477 and Cursiefen, Claus ORCID: 0000-0002-1958-411X (2024). The role of lymphatic vessels in corneal fluid homeostasis and wound healing. Journal of Ophthalmic Inflammation and Infection, 14 (1). pp. 1-8. Springer Nature. ISSN 1869-5760

PDF s12348-023-00381-y.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (1MB)

Abstract

[Artikel-Nr.: 4] The cornea, essential for vision, is normally avascular, transparent, and immune-privileged. However, injuries or infections can break this privilege, allowing blood and lymphatic vessels to invade, potentially impairing vision and causing immune responses. This review explores the complex role of corneal lymphangiogenesis in health and diseases. Traditionally, the cornea was considered devoid of lymphatic vessels, a phenomenon known as "corneal (lymph)angiogenic privilege." Recent advances in molecular markers have enabled the discovery of lymphatic vessels in the cornea under certain conditions. Several molecules contribute to preserving both immune and lymphangiogenic privileges. Lymphangiogenesis, primarily driven by VEGF family members, can occur directly or indirectly through macrophage recruitment. Corneal injuries and diseases disrupt these privileges, reducing graft survival rates following transplantation. However, modulation of lymphangiogenesis offers potential interventions to promote graft survival and expedite corneal edema resolution. This review underscores the intricate interplay between lymphatic vessels, immune privilege, and corneal pathologies, highlighting innovative therapeutic possibilities. Future investigations should explore the modulation of lymphangiogenesis to enhance corneal health and transparency, as well as corneal graft survival, and this benefits patients with various corneal conditions.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Hadrian, Karina UNSPECIFIED https://orcid.org/0000-0001-9713-1477 UNSPECIFIED Cursiefen, Claus UNSPECIFIED https://orcid.org/0000-0002-1958-411X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815103
Identification Number:	10.1186/s12348-023-00381-y
Journal or Publication Title:	Journal of Ophthalmic Inflammation and Infection
Volume:	14
Number:	1
Page Range:	pp. 1-8
Number of Pages:	8
Date:	22 January 2024
Publisher:	Springer Nature
ISSN:	1869-5760
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Augenheilkunde > Klinik und Poliklinik für Allgemeine Augenheilkunde
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81510