Universität zu Köln

Zaeske, Charlotte ORCID: 0000-0003-3746-8523, Zopfs, David ORCID: 0000-0001-9978-7453, Laukamp, Kai ORCID: 0000-0002-5600-5914, Lennartz, Simon ORCID: 0000-0001-7202-398X, Kottlors, Jonathan ORCID: 0000-0001-5021-6895, Goertz, Lukas ORCID: 0000-0002-2620-7611, Stetefeld, Henning ORCID: 0000-0002-8853-2145, Hof, Marion, Abdullayev, Nuran ORCID: 0000-0003-4522-537X, Kabbasch, Christoph ORCID: 0000-0003-3712-2258, Schlamann, Marc ORCID: 0000-0002-7734-611X and Schönfeld, Michael ORCID: 0000-0003-2096-3448 (2024). Immediate angiographic control after intra-arterial nimodipine administration underestimates the vasodilatory effect. Scientific Reports, 14 (1). pp. 1-7. Springer Nature. ISSN 2045-2322

PDF s41598-024-56807-7.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (1MB)

Abstract

[Artikel-Nr.: 6154] Intra-arterial nimodipine administration is a widely used rescue therapy for cerebral vasospasm. Although it is known that its effect sets in with delay, there is little evidence in current literature. Our aim was to prove that the maximal vasodilatory effect is underestimated in direct angiographic controls. We reviewed all cases of intra-arterial nimodipine treatment for subarachnoid hemorrhage-related cerebral vasospasm between January 2021 and December 2022. Inclusion criteria were availability of digital subtraction angiography runs before and after nimodipine administration and a delayed run for the most affected vessel at the end of the procedure to decide on further escalation of therapy. We evaluated nimodipine dose, timing of administration and vessel diameters. Delayed runs were performed in 32 cases (19 patients) with a mean delay of 37.6 (± 16.6) min after nimodipine administration and a mean total nimodipine dose of 4.7 (± 1.2) mg. Vessel dilation was more pronounced in delayed vs. immediate controls, with greater changes in spastic vessel segments (n = 31: 113.5 (± 78.5%) vs. 32.2% (± 27.9%), p < 0.0001) vs. non-spastic vessel segments (n = 32: 23.1% (± 13.5%) vs. 13.3% (± 10.7%), p < 0.0001). In conclusion intra-arterially administered nimodipine seems to exert a delayed vasodilatory effect, which should be considered before escalation of therapy.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Zaeske, Charlotte UNSPECIFIED https://orcid.org/0000-0003-3746-8523 UNSPECIFIED Zopfs, David UNSPECIFIED https://orcid.org/0000-0001-9978-7453 UNSPECIFIED Laukamp, Kai UNSPECIFIED https://orcid.org/0000-0002-5600-5914 UNSPECIFIED Lennartz, Simon UNSPECIFIED https://orcid.org/0000-0001-7202-398X UNSPECIFIED Kottlors, Jonathan UNSPECIFIED https://orcid.org/0000-0001-5021-6895 UNSPECIFIED Goertz, Lukas UNSPECIFIED https://orcid.org/0000-0002-2620-7611 UNSPECIFIED Stetefeld, Henning UNSPECIFIED https://orcid.org/0000-0002-8853-2145 UNSPECIFIED Hof, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Abdullayev, Nuran UNSPECIFIED https://orcid.org/0000-0003-4522-537X UNSPECIFIED Kabbasch, Christoph UNSPECIFIED https://orcid.org/0000-0003-3712-2258 UNSPECIFIED Schlamann, Marc UNSPECIFIED https://orcid.org/0000-0002-7734-611X UNSPECIFIED Schönfeld, Michael UNSPECIFIED https://orcid.org/0000-0003-2096-3448 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815232
Identification Number:	10.1038/s41598-024-56807-7
Journal or Publication Title:	Scientific Reports
Volume:	14
Number:	1
Page Range:	pp. 1-7
Number of Pages:	7
Date:	14 March 2024
Publisher:	Springer Nature
ISSN:	2045-2322
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Neurochirurgie > Klinik für Allgemeine Neurochirurgie Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Faculty of Medicine > Radiologische Diagnostik > Institut und Poliklinik für Radiologische Diagnostik
Subjects:	Life sciences Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81523