Universität zu Köln

Eich, Marie-Lisa ORCID: 0000-0002-8601-4598, Jeske, Wiebke, Zenz, Uschi, Chiapponi, Costanza ORCID: 0000-0002-4681-2835, Alidousty, Christina ORCID: 0000-0001-8815-1177, Merkelbach-Bruse, Sabine ORCID: 0000-0002-0312-5760, Büttner, Reinhard ORCID: 0000-0001-8806-4786 and Schultheis, Anne M. ORCID: 0000-0002-9078-5432 (2024). TERT RNAscope analysis of sub-centimetric papillary thyroid carcinomas and synchronous lymph node metastases. Thyroid Research, 17 (1). pp. 1-7. Springer Nature. ISSN 1756-6614

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Abstract

[Artikel-Nr.: 8] Background: Sub-centrimetric papillary thyroid carcinomas usually have a good prognosis with a cancer specific survival of > 99%, however in up to 65% of patients, lymph node metastases can be observed. Molecular alterations in BRAF, TERT and TP53 are associated with worse clinicopathological outcome in patients with papillary thyroid carcinoma. Material and methods: Twenty-two cases of papillary thyroid carcinomas measuring ≤ 1 cm with synchronous lymph node metastases were examined regarding morphological patterns and immunohistochemical status of p53, Ki-67, and BRAF V600E status. TERT RNA expression in lymph node metastases were evaluated by RNAScope®. Results: Morphological patterns were heterogeneous in both primary tumors and lymph node metastases. Proliferation indices measured by Ki-67 were low. Both primary and lymph node metastases were wild type for p53 by immunohistochemical analysis. No lymph node metastasis showed TERT expression by RNAScope®. Conclusions: Our data indicate that TERT expression is not involved in the development early lymph node metastasis in patients with sub-centimetric PTC.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Eich, Marie-Lisa UNSPECIFIED https://orcid.org/0000-0002-8601-4598 UNSPECIFIED Jeske, Wiebke UNSPECIFIED UNSPECIFIED UNSPECIFIED Zenz, Uschi UNSPECIFIED UNSPECIFIED UNSPECIFIED Chiapponi, Costanza UNSPECIFIED https://orcid.org/0000-0002-4681-2835 UNSPECIFIED Alidousty, Christina UNSPECIFIED https://orcid.org/0000-0001-8815-1177 UNSPECIFIED Merkelbach-Bruse, Sabine UNSPECIFIED https://orcid.org/0000-0002-0312-5760 UNSPECIFIED Büttner, Reinhard UNSPECIFIED https://orcid.org/0000-0001-8806-4786 UNSPECIFIED Schultheis, Anne M. UNSPECIFIED https://orcid.org/0000-0002-9078-5432 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815381
Identification Number:	10.1186/s13044-024-00195-7
Journal or Publication Title:	Thyroid Research
Volume:	17
Number:	1
Page Range:	pp. 1-7
Number of Pages:	7
Date:	15 April 2024
Publisher:	Springer Nature
ISSN:	1756-6614
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Chirurgie > Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Transplantationschirurgie Faculty of Medicine > Pathologie und Neuropathologie > Institut für Pathologie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language TERT, Sub‑centimetric papillary thyroid carcinoma, RNAscope® English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81538