Universität zu Köln

Dzialas, Verena ORCID: 0000-0001-7226-6674, Hoenig, Merle C., Prange, Stéphane, Bischof, Gérard N., Drzezga, Alexander ORCID: 0000-0001-6018-716X and van Eimeren, Thilo ORCID: 0000-0002-6951-2325 (2024). Structural underpinnings and long-term effects of resilience in Parkinson’s disease. npj Parkinson's Disease, 10 (1). pp. 1-11. Springer Nature. ISSN 2373-8057

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Abstract

[Artikel-Nr.: 94] Resilience in neuroscience generally refers to an individual’s capacity to counteract the adverse effects of a neuropathological condition. While resilience mechanisms in Alzheimer’s disease are well-investigated, knowledge regarding its quantification, neurobiological underpinnings, network adaptations, and long-term effects in Parkinson’s disease is limited. Our study involved 151 Parkinson’s patients from the Parkinson’s Progression Marker Initiative Database with available Magnetic Resonance Imaging, Dopamine Transporter Single-Photon Emission Computed Tomography scans, and clinical information. We used an improved prediction model linking neuropathology to symptom severity to estimate individual resilience levels. Higher resilience levels were associated with a more active lifestyle, increased grey matter volume in motor-associated regions, a distinct structural connectivity network and maintenance of relative motor functioning for up to a decade. Overall, the results indicate that relative maintenance of motor function in Parkinson’s patients may be associated with greater neuronal substrate, allowing higher tolerance against neurodegenerative processes through dynamic network restructuring.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Dzialas, Verena UNSPECIFIED https://orcid.org/0000-0001-7226-6674 UNSPECIFIED Hoenig, Merle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prange, Stéphane UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischof, Gérard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED https://orcid.org/0000-0001-6018-716X UNSPECIFIED van Eimeren, Thilo UNSPECIFIED https://orcid.org/0000-0002-6951-2325 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815431
Identification Number:	10.1038/s41531-024-00699-x
Journal or Publication Title:	npj Parkinson's Disease
Volume:	10
Number:	1
Page Range:	pp. 1-11
Number of Pages:	11
Date:	2 May 2024
Publisher:	Springer Nature
ISSN:	2373-8057
Language:	English
Faculty:	External institution Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Medicine > Neurologie > Zentrum für Neurologie Faculty of Medicine > Nuklearmedizin > Klinik und Poliklinik für Nuklearmedizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81543