Sauerbier, Anna 
ORCID: 0000-0003-0966-5933, Herberg, Johanna, Stopic, Vasilija ORCID: 0009-0004-9395-6737, Loehrer, Philipp A. ORCID: 0000-0002-5279-2156, Ashkan, Keyoumars, Rizos, Alexandra, Jost, Stefanie T. ORCID: 0000-0003-0477-2289, Petry-Schmelzer, Jan Niklas ORCID: 0000-0003-0749-3840, Gronostay, Alexandra, Schneider, Christian, Visser-Vandewalle, Veerle ORCID: 0000-0002-5274-7929, Evans, Julian, Nimsky, Christopher ORCID: 0000-0002-8216-9410, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Antonini, Angelo ORCID: 0000-0003-1040-2807, Martinez-Martin, Pablo, Silverdale, Monty, Weintraub, Daniel ORCID: 0000-0003-0633-7168, Schrag, Anette ORCID: 0000-0002-9872-6680, Ray Chaudhuri, K. ORCID: 0000-0003-2815-0505, Timmermann, Lars, Dafsari, Haidar S. ORCID: 0000-0001-8849-4233, Adler, Charles, Bhidayasiri, Roongroj, Borghammer, Per, Barone, Paolo, Brooks, David J., Brown, Richard, Cantillon, Marc, Carroll, Camille, Coelho, Miguel, Falup-Pecurariu, Cristian, Henriksen, Tove, Hu, Michele, Jenner, Peter, Jeon, Beomseok, Kramberger, Milica, Kumar, Padma, Kurtis, Mónica, Leta, Valentina, Lewis, Simon, Litvan, Irene, Lyons, Kelly, Martino, Davide, Masellis, Mario, Mochizuki, Hideki, Morley, James F., Nirenberg, Melissa, Odin, Per, Pagonabarraga, Javier, Panicker, Jalesh, Pavese, Nicola, Pekkonen, Eero, Postuma, Ron, Rodriguez Violante, Mayela, Rosales, Raymond, Schapira, Anthony, Simuni, Tanya, Stocchi, Fabrizio, Storch, Alexander, Subramanian, Indu, Tagliati, Michele, Tinazzi, Michele, Toledo, Jon, Tsuboi, Yoshio and Walker, Richard
(2024).
Predictors of short-term anxiety outcome in subthalamic stimulation for Parkinson’s disease.
npj Parkinson's Disease, 10 (1).
pp. 1-9.
Springer Nature.
ISSN 2373-8057
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Abstract
[Artikel-Nr.: 114] The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s disease (PD) are understudied. We identified clinical predictors of STN-DBS effects on anxiety in this study. In this prospective, open-label, multicentre study, we assessed patients with anxiety undergoing STN-DBS for PD preoperatively and at 6-month follow-up postoperatively. We assessed the Hospital Anxiety and Depression Scale (HADS-anxiety and depression subscales), Unified PD Rating Scale-motor examination, Scales for Outcomes in PD-motor (SCOPA-M)-activities of daily living (ADL) and -motor complications, Non-Motor Symptom Scale (NMSS), PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose. We tested changes at follow-up with Wilcoxon signed-rank test and corrected for multiple comparisons (Bonferroni method). We identified patients with a clinically relevant anxiety improvement of anxiety based on a designated threshold of ½ standard deviation of baseline HADS-anxiety. Moreover, we investigated predictors of HADS-anxiety changes with correlations and linear regressions. We included 50 patients with clinically relevant baseline anxiety (i.e., HADS-anxiety ≥ 8) aged 63.1 years ± 8.3 with 10.4 years ± 4.5 PD duration. HADS-anxiety improved significantly at 6-month follow-up as 80% of our cohort experienced clinically relevant anxiety improvement. In predictor analyses, worse baseline SCOPA-ADL and NMSS-urinary domain were associated with greater HADS-anxiety improvements. HADS-anxiety and PDQ-8 changes correlated moderately. Worse preoperative ADL and urinary symptoms predicted favourable postoperative anxiety outcome, which in turn was directly proportionate to greater QoL improvement. This study highlights the importance of detailed anxiety assessments alongside other non-motor and motor symptoms when advising and monitoring patients undergoing STN-DBS for PD.
| Item Type: | Article |
| Creators: | Creators Email ORCID ORCID Put Code Herberg, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Ashkan, Keyoumars UNSPECIFIED UNSPECIFIED UNSPECIFIED Rizos, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Gronostay, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Evans, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez-Martin, Pablo UNSPECIFIED UNSPECIFIED UNSPECIFIED Silverdale, Monty UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Charles UNSPECIFIED UNSPECIFIED UNSPECIFIED Bhidayasiri, Roongroj UNSPECIFIED UNSPECIFIED UNSPECIFIED Borghammer, Per UNSPECIFIED UNSPECIFIED UNSPECIFIED Barone, Paolo UNSPECIFIED UNSPECIFIED UNSPECIFIED Brooks, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brown, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Cantillon, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Carroll, Camille UNSPECIFIED UNSPECIFIED UNSPECIFIED Coelho, Miguel UNSPECIFIED UNSPECIFIED UNSPECIFIED Falup-Pecurariu, Cristian UNSPECIFIED UNSPECIFIED UNSPECIFIED Henriksen, Tove UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Michele UNSPECIFIED UNSPECIFIED UNSPECIFIED Jenner, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Jeon, Beomseok UNSPECIFIED UNSPECIFIED UNSPECIFIED Kramberger, Milica UNSPECIFIED UNSPECIFIED UNSPECIFIED Kumar, Padma UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurtis, Mónica UNSPECIFIED UNSPECIFIED UNSPECIFIED Leta, Valentina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Litvan, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED Lyons, Kelly UNSPECIFIED UNSPECIFIED UNSPECIFIED Martino, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED Masellis, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Mochizuki, Hideki UNSPECIFIED UNSPECIFIED UNSPECIFIED Morley, James F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nirenberg, Melissa UNSPECIFIED UNSPECIFIED UNSPECIFIED Odin, Per UNSPECIFIED UNSPECIFIED UNSPECIFIED Pagonabarraga, Javier UNSPECIFIED UNSPECIFIED UNSPECIFIED Panicker, Jalesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Pavese, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Pekkonen, Eero UNSPECIFIED UNSPECIFIED UNSPECIFIED Postuma, Ron UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodriguez Violante, Mayela UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosales, Raymond UNSPECIFIED UNSPECIFIED UNSPECIFIED Schapira, Anthony UNSPECIFIED UNSPECIFIED UNSPECIFIED Simuni, Tanya UNSPECIFIED UNSPECIFIED UNSPECIFIED Stocchi, Fabrizio UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Subramanian, Indu UNSPECIFIED UNSPECIFIED UNSPECIFIED Tagliati, Michele UNSPECIFIED UNSPECIFIED UNSPECIFIED Tinazzi, Michele UNSPECIFIED UNSPECIFIED UNSPECIFIED Toledo, Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsuboi, Yoshio UNSPECIFIED UNSPECIFIED UNSPECIFIED Walker, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED |
| URN: | urn:nbn:de:hbz:38-815656 |
| Identification Number: | 10.1038/s41531-024-00701-6 |
| Journal or Publication Title: | npj Parkinson's Disease |
| Volume: | 10 |
| Number: | 1 |
| Page Range: | pp. 1-9 |
| Number of Pages: | 9 |
| Date: | 8 June 2024 |
| Publisher: | Springer Nature |
| ISSN: | 2373-8057 |
| Language: | English |
| Faculty: | Faculty of Medicine |
| Divisions: | Faculty of Medicine > Neurochirurgie > Klinik für Stereotaxie und funktionelle Neurochirurgie Faculty of Medicine > Neurologie > Zentrum für Neurologie |
| Subjects: | Medical sciences Medicine |
| ['eprint_fieldname_oa_funders' not defined]: | Publikationsfonds UzK |
| Refereed: | Yes |
| URI: | http://kups.ub.uni-koeln.de/id/eprint/81565 |
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