Universität zu Köln

Kruse, Teresa ORCID: 0000-0002-3431-7749, Leflerovà, Diana ORCID: 0000-0003-3001-7164, Cap, Annette, Portegys, Sara, Wirth, Brunhilde ORCID: 0000-0003-4051-5191, Heller, Raoul, Brakemeier, Svenja, Hagenacker, Tim, Braumann, Bert ORCID: 0000-0002-5031-9816 and Wunderlich, Gilbert ORCID: 0000-0001-5544-335X (2024). Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach. Orphanet Journal of Rare Diseases, 19 (1). pp. 1-13. Springer Nature. ISSN 1750-1172

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Abstract

[Artikel-Nr.: 382] Background: Oral function tests have been shown to reliably detect impaired bulbar function in adults with spinal muscular atrophy (SMA). Although not routinely recorded, it is known that persons with SMA are affected to varying degrees. Detecting differences in bite and tongue force, endurance, and maximum mouth opening has become particularly promising since the introduction of causal therapy for SMA. This study aimed to compare oral function among adult persons with SMA with different SMA types, walking abilities, and treatment status to a healthy control group. Methods: Data from oral function tests conducted on 58 persons with SMA and 45 healthy individuals were analyzed. Differences in oral function between SMA subgroups were pairwise tested and compared to the healthy control group using Wilcoxon rank sum tests. Results: In an overall comparison, three out of five oral function tests revealed lower values for the SMA group compared to the control group. Subgroup analyses indicated lower scores for most oral function tests in non-ambulatory, untreated patients with SMA type 2 compared to controls. Ambulatory, treated patients with SMA type 3 achieved strength and endurance values comparable to those of healthy individuals. Conclusions: The impairment of oral function varies across persons with SMA. Routine measurement of oral function is warranted to determine individual bulbar involvement stages. Further evaluation should be scheduled if indicators such as restricted maximum mouth opening arise. Trial registration DRKS, DRKS00015842. Registered 30 July 2019, https://drks.de/register/de/trial/DRKS00015842/preview .

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Kruse, Teresa UNSPECIFIED https://orcid.org/0000-0002-3431-7749 UNSPECIFIED Leflerovà, Diana UNSPECIFIED https://orcid.org/0000-0003-3001-7164 UNSPECIFIED Cap, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Portegys, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirth, Brunhilde UNSPECIFIED https://orcid.org/0000-0003-4051-5191 UNSPECIFIED Heller, Raoul UNSPECIFIED UNSPECIFIED UNSPECIFIED Brakemeier, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagenacker, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Braumann, Bert UNSPECIFIED https://orcid.org/0000-0002-5031-9816 UNSPECIFIED Wunderlich, Gilbert UNSPECIFIED https://orcid.org/0000-0001-5544-335X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-815879
Identification Number:	10.1186/s13023-024-03405-5
Journal or Publication Title:	Orphanet Journal of Rare Diseases
Volume:	19
Number:	1
Page Range:	pp. 1-13
Date:	15 October 2024
Publisher:	Springer Nature
ISSN:	1750-1172
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Weitere > Zentrum für seltene Erkrankungen Faculty of Medicine > Zahn-, Mund- und Kieferheilkunde > Poliklinik für Kieferorthopädie Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Spinal muscular atrophy ; Bulbar neuromuscular function ; Outcome measures ; Bite force ; Tongue pressure ; Endurance English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81587