Universität zu Köln

Zorrón, Melanie ORCID: 0009-0006-7525-4293, Cabrera, Agustín López ORCID: 0000-0002-1724-4963, Sharma, Riya, Radhakrishnan, Janani, Abbaszadeh, Samin, Shahbazi, Mohammad‐Ali, Tafreshi, Omid Aghababaei, Karamikamkar, Solmaz and Maleki, Hajar ORCID: 0000-0002-2813-4700 (2024). Emerging 2D Nanomaterials‐Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy. Advanced Science, 11 (31). pp. 1-65. Wiley. ISSN 2198-3844

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Abstract

[Artikel-Nr.: 2403204] This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D‐material integrated hydrogels, with a focus on their performance in bone‐related applications. Various synthesis methods and types of 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, and MXene are discussed, along with strategies for their incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical properties, high surface area, strong near‐infrared (NIR) photon absorption and controlled release capabilities, making them suitable for a range of regeneration and therapeutic applications. In cancer therapy, 2D‐material‐based hydrogels show promise for photothermal and photodynamic therapies, and drug delivery (chemotherapy). The photothermal properties of these materials enable selective tumor ablation upon NIR irradiation, while their high drug‐loading capacity facilitates targeted and controlled release of chemotherapeutic agents. Additionally, 2D‐materials ‐infused hydrogels exhibit potent antibacterial activity, making them effective against multidrug‐resistant infections and disruption of biofilm generated on implant surface. Moreover, their synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, and immunotherapy to enhance therapeutic outcomes. In bio‐imaging, these materials serve as versatile contrast agents and imaging probes, enabling their real‐time monitoring during tumor imaging. Furthermore, in bone regeneration, most 2D‐materials incorporated hydrogels promote osteogenesis and tissue regeneration, offering potential solutions for bone defects repair. Overall, the integration of 2D materials into hydrogels presents a promising platform for developing multifunctional theragenerative biomaterials.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Zorrón, Melanie UNSPECIFIED https://orcid.org/0009-0006-7525-4293 UNSPECIFIED Cabrera, Agustín López UNSPECIFIED https://orcid.org/0000-0002-1724-4963 UNSPECIFIED Sharma, Riya UNSPECIFIED UNSPECIFIED UNSPECIFIED Radhakrishnan, Janani UNSPECIFIED UNSPECIFIED UNSPECIFIED Abbaszadeh, Samin UNSPECIFIED UNSPECIFIED UNSPECIFIED Shahbazi, Mohammad‐Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Tafreshi, Omid Aghababaei UNSPECIFIED UNSPECIFIED UNSPECIFIED Karamikamkar, Solmaz UNSPECIFIED UNSPECIFIED UNSPECIFIED Maleki, Hajar UNSPECIFIED https://orcid.org/0000-0002-2813-4700 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-816328
Identification Number:	10.1002/advs.202403204
Journal or Publication Title:	Advanced Science
Volume:	11
Number:	31
Page Range:	pp. 1-65
Number of Pages:	65
Date:	14 August 2024
Publisher:	Wiley
ISSN:	2198-3844
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry Zentrum für Molekulare Medizin
Subjects:	Chemistry and allied sciences
Uncontrolled Keywords:	Keywords Language 2D nanomaterials ; bone cancer therapy ; bone regeneration ; composites ; hydrogel ; theragenerative materials English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/81632