Universität zu Köln

Göbel, J., Bergami, Matteo and Motori, E. (2018). Spatiotemporal control of mitochondrial network dynamics in astroglial cells. Biochemical and Biophysical Research Communications, 500 (1). p. 17. Elsevier B.V.. ISSN 0006-291X

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Abstract

Mitochondria are increasingly recognized for playing important roles in regulating the evolving metabolic state of mammalian cells. This is particularly true for nerve cells, as dysregulation of mitochondrial dynamics are invariably associated with a number of neuropathies. Accumulating evidence now reveals that changes in mitochondrial dynamics and structure may play equally important roles also in the cell biology of astroglial cells. Astroglial cells display a significant heterogeneity in their morphology and specialized functions across the different brain regions, however besides fundamental differences they seem to share a surprisingly complex meshwork of mitochondria, which is highly suggestive of tightly regulated mechanisms that contribute to maintain this unique architecture. Here, we summarize recent work performed in astrocytes in situ indicating that this may indeed be the case, with astrocytic mitochondrial networks shown to experience rapid dynamic changes in response to defined external cues. Although the mechanisms underlying this degree of mitochondrial re-shaping are far from being understood, recent data suggest that they may contribute to demarcate astrocyte territories undergoing key signalling and metabolic functions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Göbel, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergami, Matteo UNSPECIFIED UNSPECIFIED UNSPECIFIED Motori, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-94743
DOI:	10.1016/j.bbrc.2017.06.191
Journal or Publication Title:	Biochemical and Biophysical Research Communications
Volume:	500
Number:	1
Page Range:	p. 17
Date:	2018
Publisher:	Elsevier B.V.
ISSN:	0006-291X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases
Subjects:	Life sciences
Funders:	European Research Council (ERC-StG-2015, grant number 67844), Deutsche Forschungsgemeinschaft (CRC 1218)
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/9474