Universität zu Köln

Journal Article

Aoki, Shuichi, Inoue, Koetsu, Klein, Sebastian ORCID: 0000-0002-2188-9377, Halvorsen, Stefan, Chen, Jiang, Matsui, Aya, Nikmaneshi, Mohammad R., Kitahara, Shuji ORCID: 0000-0002-2904-0319, Hato, Tai ORCID: 0000-0002-1319-505X, Chen, Xianfeng ORCID: 0000-0002-7531-5862, Kawakubo, Kazumichi ORCID: 0000-0002-8979-9474, Nia, Hadi T., Chen, Ivy, Schanne, Daniel H., Mamessier, Emilie ORCID: 0000-0002-3516-0093, Shigeta, Kohei ORCID: 0000-0003-1596-4200, Kikuchi, Hiroto, Ramjiawan, Rakesh R., Schmidt, Tyge C. E., Iwasaki, Masaaki, Yau, Thomas, Hong, Theodore S., Quaas, Alexander, Plum, Patrick S. ORCID: 0000-0002-8165-4553, Dima, Simona, Popescu, Irinel, Bardeesy, Nabeel, Munn, Lance L., Borad, Mitesh J., Sassi, Slim, Jain, Rakesh K., Zhu, Andrew X. and Duda, Dan G. (2022). Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut, 71 (1). S. 185 - 194. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-3288

Bochtler, Tilmann, Endris, Volker, Reiling, Anna, Leichsenring, Jonas, Schweiger, Michal R., Klein, Sebastian, Stoegbauer, Fabian, Goeppert, Benjamin ORCID: 0000-0002-4135-9250, Schirmacher, Peter, Kraemer, Alwin and Stenzinger, Albrecht (2018). Integrated Histogenetic Analysis Reveals BAP1-Mutated Epithelioid Mesothelioma in a Patient With Cancer of Unknown Primary. J. Natl. Compr. Cancer Netw., 16 (6). S. 677 - 683. COLD SPRING HARBOR: HARBORSIDE PRESS. ISSN 1540-1413

Braegelmann, Johannes, Lorenz, Carina, Borchmann, Sven ORCID: 0000-0001-6662-6864, Nishii, Kazuya, Wegner, Julia ORCID: 0000-0001-8103-8040, Meder, Lydia, Ostendorp, Jenny, Ast, David F., Heimsoeth, Alena, Nakasuka, Takamasa, Hirabae, Atsuko, Okawa, Sachi, Dammert, Marcel A., Plenker, Dennis, Klein, Sebastian ORCID: 0000-0002-2188-9377, Lohneis, Philipp, Gu, Jianing, Godfrey, Laura K., Forster, Jan, Trajkovic-Arsic, Marija, Zillinger, Thomas, Haarmann, Mareike, Quaas, Alexander, Lennartz, Stefanie, Schmiel, Marcel, D'Rozario, Joshua, Thomas, Emily S., Li, Henry, Schmitt, Clemens A. ORCID: 0000-0002-4731-2226, George, Julie, Thomas, Roman K., von Karstedt, Silvia, Hartmann, Gunther, Buettner, Reinhard, Ullrich, Roland T., Siveke, Jens T., Ohashi, Kadoaki, Schlee, Martin ORCID: 0000-0003-3671-7639 and Sos, Martin L. (2021). MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Nat. Commun., 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

Chen, Dawei ORCID: 0000-0002-2541-4512, Nemazanyy, Ivan, Peulen, Olivier ORCID: 0000-0002-6933-0134, Shostak, Kateryna, Xu, Xinyi, Tang, Seng Chuan, Wathieu, Caroline, Turchetto, Silvia, Tielens, Sylvia, Nguyen, Laurent, Close, Pierre, Desmet, Christophe, Klein, Sebastian, Florin, Alexandra, Buttner, Reinhard, Petrellis, Georgios, Dewals, Benjamin and Chariot, Alain (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. Embo J., 41 (18). HOBOKEN: WILEY. ISSN 1460-2075

Dalvi, Priya S., Kacheleidt, Iris F., Lim, So-Young, Meemboor, Sonja, Mueller, Marion, Eischeid-Scholz, Hannah, Schaefer, Stephan C., Buettner, Reinhard, Klein, Sebastian and Odenthal, Margarete ORCID: 0000-0002-2424-0960 (2019). LSD1 Inhibition Attenuates Tumor Growth by Disrupting PLK1 Mitotic Pathway. Mol. Cancer Res., 17 (6). S. 1326 - 1338. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1557-3125

Dammed, Marcel A., Bragelmann, Johannes, Olsen, Rachelle R., Boehm, Stefanie, Monhasery, Niloufar, Whitney, Christopher P., Chalishazar, Milind D., Tumbrink, Hannah L., Guthrie, Matthew R., Klein, Sebastian, Irelands, Abbie S., Ryan, Jeremy, Schmitt, Anna, Marx, Annika, Ozretic, Luka, Castiglione, Roberta ORCID: 0000-0002-9828-4405, Lorenz, Carina, Jachimowicz, Ron D., Wolf, Elmar ORCID: 0000-0002-5299-6335, Thomas, Roman K., Poirier, John T., Buettner, Reinhard, Sen, Triparna, Byers, Lauren A., Reinhardt, H. Christian, Letai, Anthony, Oliver, Trudy G. and Sos, Martin L. (2019). MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Duda, Dan G., Dima, Simona O., Cucu, Dana, Sorop, Andrei, Klein, Sebastian ORCID: 0000-0002-2188-9377, Ancukiewicz, Marek, Kitahara, Shuji ORCID: 0000-0002-2904-0319, Iacob, Speranta, Bacalbasa, Nicolae, Tomescu, Dana ORCID: 0000-0001-9673-5754, Herlea, Vlad, Tanase, Cristiana, Croitoru, Adina and Popescu, Irinel (2020). Potential Circulating Biomarkers of Recurrence after Hepatic Resection or Liver Transplantation in Hepatocellular Carcinoma Patients. Cancers, 12 (5). BASEL: MDPI. ISSN 2072-6694

Fassunke, Jana, Mueller, Fabienne, Keul, Marina, Michels, Sebastian, Dammert, Marcel A., Schmitt, Anna, Plenker, Dennis, Lategahn, Jonas ORCID: 0000-0001-5993-7082, Heydt, Carina, Braegelmann, Johannes, Tumbrink, Hannah L., Alber, Yannic, Klein, Sebastian, Heimsoeth, Alena, Dahmen, Ilona, Fischers, Rieke N., Scheffler, Matthias, Ihle, Michaela A., Priesner, Vanessa, Scheel, Andreas H., Wagener, Svenja, Kron, Anna, Frank, Konrad, Garbert, Katia, Persigehl, Thorsten, Puesken, Michael, Haneder, Stefan, Schaaf, Bernhard, Rodermann, Ernst, Engel-Riedel, Walburga, Felip, Enriqueta, Smit, Egbert F., Merkelbach-Bruse, Sabine, Reinhardt, H. Christian, Kast, Stefan M., Wolf, Juergen, Rauh, Daniel, Buettner, Reinhard and Sos, Martin L. (2018). Overcoming EGFR(G724S)-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors. Nat. Commun., 9. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Fluemann, Ruth, Rehkaemper, Tim, Nieper, Pascal, Pfeiffer, Pauline, Holzem, Alessandra, Klein, Sebastian ORCID: 0000-0002-2188-9377, Bhatia, Sanil ORCID: 0000-0001-6494-7744, Kochanek, Moritz, Kisis, Ilmars ORCID: 0000-0001-6207-3991, Pelzer, Benedikt W., Ahlert, Heinz, Hauer, Julia, Guerreiro, Alexandra da Palma, Ryan, Jeremy A., Reimann, Maurice, Riabinska, Arina, Wiederstein, Janica, Krueger, Marcus, Deckert, Martina, Altmueller, Janine, Klatt, Andreas R., Frenzel, Lukas P., Pasqualucci, Laura, Beguelin, Wendy, Melnick, Ari M., Sander, Sandrine, Montesinos-Rongen, Manuel ORCID: 0000-0003-4724-5526, Brunn, Anna, Lohneis, Philipp, Buettner, Reinhard, Kashkar, Hamid, Borkhardt, Arndt, Letai, Anthony, Persigehl, Thorsten, Peifer, Martin, Schmitt, Clemens A. ORCID: 0000-0002-4731-2226, Reinhardt, Hans Christian and Knittel, Gero ORCID: 0000-0001-8395-3701 (2021). An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities. Blood Cancer Discov., 2 (1). S. 70 - 92. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 2643-3249

Grasse, Sabrina, Lienhard, Matthias, Frese, Steffen, Kerick, Martin ORCID: 0000-0002-6298-4514, Steinbach, Anne, Grimm, Christina ORCID: 0000-0002-4676-8870, Hussong, Michelle, Rolff, Jana, Becker, Michael, Dreher, Felix, Schirmer, Uwe, Boerno, Stefan, Ramisch, Anna, Leschber, Gunda, Timmermann, Bernd, Grohe, Christian, Lueders, Heike, Vingron, Martin, Fichtner, Iduna, Klein, Sebastian, Odenthal, Margarete, Buettner, Reinhard, Lehrach, Hans, Sueltmann, Holger, Herwig, Ralf and Schweiger, Michal R. (2018). Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance. Genome Med., 10. LONDON: BMC. ISSN 1756-994X

Helbig, Doris and Klein, Sebastian (2022). Immune checkpoint inhibitors for unresectable or metastatic pleomorphic dermal sarcomas. Front. Oncol., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2234-943X

Klein, Sebastian ORCID: 0000-0002-2188-9377 and Duda, Dan G. ORCID: 0000-0001-7065-8797 (2021). Machine Learning for Future Subtyping of the Tumor Microenvironment of Gastro-Esophageal Adenocarcinomas. Cancers, 13 (19). BASEL: MDPI. ISSN 2072-6694

Klein, Sebastian, Fangman, Linda, Kruis, Wolfgang, Dienes, Hans-Peter, Odenthal, Margarete and Drebber, Uta (2018). Autochthonous acute hepatitis E mimicking CMV infection. Clin. Res. Hepatol. Gastroenterol., 42 (4). S. E63 - 3. PARIS: ELSEVIER MASSON, CORPORATION OFFICE. ISSN 2210-741X

Klein, Sebastian ORCID: 0000-0002-2188-9377, Gildenblat, Jacob, Ihle, Michaele Angelika, Merkelbach-Bruse, Sabine, Noh, Ka-Won, Peifer, Martin, Quaas, Alexander and Buettner, Reinhard (2020). Deep learning for sensitive detection of Helicobacter Pylori in gastric biopsies. BMC Gastroenterol., 20 (1). LONDON: BMC. ISSN 1471-230X

Klein, Sebastian ORCID: 0000-0002-2188-9377, Mauch, Cornelia, Brinker, Klaus, Noh, Ka-Won, Knez, Sonja, Buettner, Reinhard, Quaas, Alexander and Helbig, Doris (2021). Tumor infiltrating lymphocyte clusters are associated with response to immune checkpoint inhibition in BRAF V600(E/K) mutated malignant melanomas. Sci Rep, 11 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

Klein, Sebastian, Mauch, Cornelia, Wagener-Ryczek, Svenja, Schoemmel, Maximilian, Buettner, Reinhard, Quaas, Alexander and Helbig, Doris (2019). Immune-phenotyping of pleomorphic dermal sarcomas suggests this entity as a potential candidate for immunotherapy. Cancer Immunol. Immunother., 68 (6). S. 973 - 983. NEW YORK: SPRINGER. ISSN 1432-0851

Klein, Sebastian ORCID: 0000-0002-2188-9377, Mentrup, Birgit, Timmen, Melanie, Sherwood, Joanna, Lindemann, Otto, Fobker, Manfred, Kronenberg, Daniel ORCID: 0000-0001-6807-7328, Pap, Thomas, Raschke, Michael J. and Stange, Richard ORCID: 0000-0003-0807-3151 (2020). Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss. Calcif. Tissue Int., 106 (6). S. 655 - 665. NEW YORK: SPRINGER. ISSN 1432-0827

Klein, Sebastian, Persa, Oana-Diana, Mauch, Cornelia, Noh, Ka-Won, Pappesch, Roberto, Wagener-Ryczek, Svenja, Buettner, Reinhard, Quaas, Alexander and Hebig, Doris (2019). First report on two cases of pleomorphic dermal sarcoma successfully treated with immune checkpoint inhibitors. OncoImmunology, 8 (12). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2162-402X

Klein, Sebastian ORCID: 0000-0002-2188-9377, Quaas, Alexander, Noh, Ka-Won, Cartolano, Maria, Abedpour, Nima, Mauch, Cornelia, Quantius, Jennifer, Reinhardt, Hans Christian, Buettner, Reinhard, Peifer, Martin and Helbig, Doris (2020). Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy. Clin. Cancer Res., 26 (21). S. 5638 - 5646. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1557-3265

Klein, Sebastian ORCID: 0000-0002-2188-9377, Quaas, Alexander, Quantius, Jennifer, Loeser, Heike, Meinel, Jorn, Peifer, Martin, Wagner, Steffen ORCID: 0000-0003-0873-1601, Gattenloehner, Stefan, Wittekindt, Claus, Doeberitz, Magnus von Knebel, Prigge, Elena-Sophie, Langer, Christine, Noh, Ka-Won, Maltseva, Margaret, Reinhardt, Hans Christian, Buettner, Reinhard, Klussmann, Jens Peter ORCID: 0000-0002-8223-7954 and Wuerdemann, Nora (2021). Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains. Clin. Cancer Res., 27 (4). S. 1131 - 1139. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1557-3265

Meder, Lydia ORCID: 0000-0002-9547-5812, Schuldt, Philipp, Thelen, Martin ORCID: 0000-0002-2785-9726, Schmitt, Anna, Dietlein, Felix, Klein, Sebastian, Borchmann, Sven, Wennhold, Kerstin, Vlasic, Ignacija, Oberbeck, Sebastian, Riedel, Richard, Florin, Alexandra, Golfmann, Kristina, Schloesser, Hans A., Odenthal, Margarete, Buettner, Reinhard, Wolf, Juergen, Hallek, Michael, Herling, Marco, von Bergwelt-Baildon, Michael, Reinhardt, H. Christian and Ullrich, Roland T. (2018). Combined VEGF and PD-L1 Blockade Displays Synergistic Treatment Effects in an Autochthonous Mouse Model of Small Cell Lung Cancer. Cancer Res., 78 (15). S. 4270 - 4282. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Noh, Ka-Won, Buettner, Reinhard and Klein, Sebastian ORCID: 0000-0002-2188-9377 (2021). Shifting Gears in Precision Oncology-Challenges and Opportunities of Integrative Data Analysis. Biomolecules, 11 (9). BASEL: MDPI. ISSN 2218-273X

Quaas, Alexander, Pamuk, Aylin, Klein, Sebastian ORCID: 0000-0002-2188-9377, Quantius, Jennifer, Rehkaemper, Jan, Barutcu, Atakan G., Rueschoff, Josef, Zander, Thomas, Gebauer, Florian, Hillmer, Axel, Buettner, Reinhard, Schroeder, Wolfgang, Bruns, Christiane J., Loeser, Heike, Schoemig-Markiefka, Birgid and Alakus, Hakan (2021). Sex-specific prognostic effect of CD66b-positive tumor-infiltrating neutrophils (TANs) in gastric and esophageal adenocarcinoma. Gastric Cancer, 24 (6). S. 1213 - 1227. NEW YORK: SPRINGER. ISSN 1436-3305

Schiller, Joanna, Klein, Sebastian, Engels, Marianne, Buettner, Reinhard, Rybniker, Jan, Faetkenheuer, Gerd, Scheid, Christof, Wybranski, Christian, Quaas, Alexander, Reinhardt, Hans Christian and Fluemann, Ruth (2018). Case Report: A Cryptosporidium infection in a patient with relapsed T-lymphoblastic lymphoma undergoing allogeneic stem cell transplantation. Eur. J. Haematol., 100 (4). S. 383 - 386. HOBOKEN: WILEY. ISSN 1600-0609

Shigeta, Kohei, Matsui, Aya, Kikuchi, Hiroto, Klein, Sebastian ORCID: 0000-0002-2188-9377, Mamessier, Emilie, Chen, Ivy X., Aoki, Shuichi, Kitahara, Shuji ORCID: 0000-0002-2904-0319, Inoue, Koetsu, Shigeta, Ayako, Hato, Tai, Ramjiawan, Rakesh R., Staiculescu, Daniel, Zopf, Dieter, Fiebig, Lukas, Hobbs, Gabriela S., Quaas, Alexander, Dima, Simona, Popescu, Irinel, Huang, Peigen, Munn, Lance L., Cobbold, Mark, Goyal, Lipika, Zhu, Andrew X., Jain, Rakesh K. and Duda, Dan G. (2020). Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma. J. Immunother. Cancer, 8 (2). LONDON: BMJ PUBLISHING GROUP. ISSN 2051-1426

Shostak, Kateryna, Jiang, Zheshen, Charloteaux, Benoit, Mayer, Alice, Habraken, Yvette, Tharun, Lars, Klein, Sebastian ORCID: 0000-0002-2188-9377, Xu, Xinyi, Vislovukh, Andrii, Close, Pierre, Florin, Alexandra, Rambow, Florian, Marine, Jean-Christophe ORCID: 0000-0003-2433-9837, Buettner, Reinhard and Chariot, Alain (2020). The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage. Nat. Commun., 11 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Tang, Seng Chuan ORCID: 0000-0002-8709-3531, Lion, Quentin, Peulen, Olivier ORCID: 0000-0002-6933-0134, Chariot, Philippe, Lavergne, Arnaud, Mayer, Alice ORCID: 0000-0002-6859-0612, Fuster, Paula Allepuz, Close, Pierre, Klein, Sebastian, Florin, Alexandra, Buettner, Reinhard, Nemazanyy, Ivan, Shostak, Kateryna and Chariot, Alain (2022). The E3 ligase COP1 promotes ER alpha signaling and suppresses EMT in breast cancer. Oncogene, 41 (2). S. 173 - 191. LONDON: SPRINGERNATURE. ISSN 1476-5594

Thelen, Martin ORCID: 0000-0002-2785-9726, Wennhold, Kerstin, Lehmann, Jonas, Garcia-Marquez, Maria, Klein, Sebastian ORCID: 0000-0002-2188-9377, Kochen, Elena ORCID: 0000-0003-2470-825X, Lohneis, Philipp, Lechner, Axel, Wagener-Ryczek, Svenja, Plum, Patrick Sven, Velazquez Camacho, Oscar, Pfister, David, Doerr, Fabian, Heldwein, Matthias, Hekmat, Khosro, Beutner, Dirk, Klussmann, Jens Peter, Thangarajah, Fabinshy, Ratiu, Dominik, Malter, Wolfram, Merkelbach-Bruse, Sabine, Bruns, Christiane Josephine, Quaas, Alexander, von Bergwelt-Baildon, Michael and Schloesser, Hans A. (2021). Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy. npj Precis. Oncol., 5 (1). BERLIN: NATURE RESEARCH. ISSN 2397-768X

Werr, Lisa ORCID: 0000-0002-3697-4136, Plenker, Dennis, Dammert, Marcel A., Lorenz, Carina, Bragelmann, Johannes, Tumbrink, Hannah L., Klein, Sebastian, Schmitt, Anna, Buttner, Reinhard, Persigehl, Thorsten, Shokat, Kevan M., Wunderlich, F. Thomas, Schram, Alison M., Peifer, Martin ORCID: 0000-0002-5243-5503, Sos, Martin L., Reinhardt, H. Christian and Thomas, Roman K. (2022). CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization. Mol. Cancer Ther., 21 (5). S. 821 - 831. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-8514

Thesis

Klein, Sebastian (2005). The complex quadric from the standpoint of Riemannian geometry. PhD thesis, Universität zu Köln.