Universität zu Köln

Journal Article

Beck, Lydia ORCID: 0000-0003-2785-1836, Witt, Ruth, Nesper-Brock, Martina, Milde, Till, Hettmer, Simone, Fruehwald, Michael C., Roessig, Claudia, Fischer, Matthias, Reinhardt, Dirk ORCID: 0000-0002-7027-4483, Taylor, Lenka A., Riedel, Claudia, Witt, Olaf and van Tilburg, Cornelis M. (2021). A Study of Regulatory Challenges of Pediatric Oncology Phase I/II Trial Submissions and Guidance on Protocol Development. Clin. Pharmacol. Ther., 110 (4). S. 1025 - 1038. HOBOKEN: WILEY. ISSN 1532-6535

Capper, David ORCID: 0000-0003-1945-497X, Jones, David T. W., Sill, Martin ORCID: 0000-0001-7616-7665, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik ORCID: 0000-0003-0250-1696, Koelsche, Christian, Sahm, Felix ORCID: 0000-0001-5441-1962, Chavez, Lukas ORCID: 0000-0002-8718-8848, Reuss, David E., Kratz, Annekathrin, Wefers, Annika K., Huang, Kristin, Pajtler, Kristian W. ORCID: 0000-0002-3562-6121, Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W., Lindenberg, Kerstin, Harter, Patrick N., Braczynski, Anne K., Plate, Karl H., Dohmen, Hildegard, Garvalov, Boyan K. ORCID: 0000-0003-0013-9064, Coras, Roland, Hoelsken, Annett, Hewer, Ekkehard ORCID: 0000-0002-9128-0364, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori ORCID: 0000-0002-0579-6701, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora ORCID: 0000-0002-3542-3770, Giangaspero, Felice ORCID: 0000-0001-5382-2380, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J., Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Juergen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri ORCID: 0000-0002-8479-0657, Tsirigos, Aristotelis ORCID: 0000-0002-7512-8477, Brueck, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Haenggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R., Kohlhof, Patricia, Kristensen, Bjarne W., Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank ORCID: 0000-0001-9816-8917, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Muehleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc ORCID: 0000-0001-8287-5967, Gottardo, Nicholas G., Driever, Pablo Hernaiz, Kramm, Christof M., Mueller, Hermann L., Rutkowski, Stefan, von Hoff, Katja, Fruehwald, Michael C., Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia-Maria, Perry, Arie, Jones, Chris ORCID: 0000-0001-8118-2296, Jacques, Thomas S., Radlwimmer, Bernhard, Gessi, Marco, Pietsch, Torsten, Schramm, Johannes, Schackert, Gabriele, Westphal, Manfred, Reifenberger, Guido, Wesseling, Pieter, Weller, Michael ORCID: 0000-0002-1748-174X, Collins, Vincent Peter, Bluemcke, Ingmar, Bendszus, Martin, Debus, Juergen, Huang, Annie, Jabado, Nada, Northcott, Paul A., Paulus, Werner, Gajjar, Amar, Robinson, Giles W., Taylor, Michael D., Jaunmuktane, Zane ORCID: 0000-0001-7738-8881, Ryzhova, Marina ORCID: 0000-0001-7206-6365, Platten, Michael ORCID: 0000-0002-4746-887X, Unterberg, Andreas, Wick, Wolfgang ORCID: 0000-0002-6171-634X, Karajannis, Matthias A., Mittelbronn, Michel, Acker, Till, Hartmann, Christian, Aldape, Kenneth, Schueller, Ulrich, Buslei, Rolf, Lichter, Peter, Kool, Marcel, Herold-Mende, Christel, Ellison, David W., Hasselblatt, Martin, Snuderl, Matija ORCID: 0000-0003-0752-0917, Brandner, Sebastian, Korshunov, Andrey ORCID: 0000-0002-5257-3623, von Deimling, Andreas ORCID: 0000-0002-5863-540X and Pfister, Stefan M. (2018). DNA methylation-based classification of central nervous system tumours. Nature, 555 (7697). S. 469 - 495. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Ecker, Jonas, Selt, Florian, Sturm, Dominik ORCID: 0000-0003-0250-1696, Sill, Martin, Korshunov, Andrey, Hirsch, Steffen, Capper, David ORCID: 0000-0003-1945-497X, Dikow, Nicola, Sutter, Christian, Mueller, Carina, Sigaud, Romain, Eggert, Angelika ORCID: 0000-0003-3476-8184, Simon, Thorsten, Niehues, Tim, von Deimling, Andreas ORCID: 0000-0002-5863-540X, Pajtler, Kristian W., van Tilburg, Cornelis M., Jones, David T. W. ORCID: 0000-0002-2036-5141, Sahm, Felix, Pfister, Stefan M., Witt, Olaf and Milde, Till ORCID: 0000-0002-7267-1052 (2023). Original Research Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry. Eur. J. Cancer, 180. S. 71 - 85. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

Fabian, Johannes, Lodrini, Marco, Oehme, Ina, Schier, Marie C., Thole, Theresa M., Hielscher, Thomas, Kopp-Schneider, Annette ORCID: 0000-0002-1810-0267, Opitz, Lennart, Capper, David ORCID: 0000-0003-1945-497X, von Deimling, Andreas ORCID: 0000-0002-5863-540X, Wiegand, Inga, Milde, Till ORCID: 0000-0002-7267-1052, Mahlknecht, Ulrich, Westermann, Frank, Popanda, Odilia, Roels, Frederik, Hero, Barbara, Berthold, Frank, Fischer, Matthias, Kulozik, Andreas E., Witt, Olaf and Deubzer, Hedwig E. (2014). GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3. Cancer Res., 74 (9). S. 2604 - 2617. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Koelsche, Christian ORCID: 0000-0001-8763-8864, Schrimpf, Daniel, Stichel, Damian, Sill, Martin, Sahm, Felix ORCID: 0000-0001-5441-1962, Reuss, David E., Blattner, Mirjam, Worst, Barbara, Heilig, Christoph E. ORCID: 0000-0001-8869-1421, Beck, Katja, Horak, Peter ORCID: 0000-0003-4536-9306, Kreutzfeldt, Simon, Paff, Elke, Stark, Sebastian, Johann, Pascal, Selt, Florian, Ecker, Jonas, Sturm, Dominik, Pajtler, Kristian W., Reinhardt, Annekathrin, Wefers, Annika K. ORCID: 0000-0001-9394-8519, Sievers, Philipp, Ebrahimi, Azadeh ORCID: 0000-0001-7354-1746, Suwala, Abigail, Fernandez-Klett, Francisco, Casalini, Belen, Korshunov, Andrey, Hovestadt, Volker, Kommoss, Felix K. F., Kriegsmann, Mark ORCID: 0000-0002-7319-3646, Schick, Matthias, Bewerunge-Hudler, Melanie, Milde, Till ORCID: 0000-0002-7267-1052, Witt, Olaf, Kulozik, Andreas E., Kool, Marcel, Romero-Perez, Laura, Gruenewald, Thomas G. P., Kirchner, Thomas, Wick, Wolfgang, Platten, Michael ORCID: 0000-0002-4746-887X, Unterberg, Andreas, Uhl, Matthias, Abdollahi, Amir, Debus, Juergen, Lehner, Burkhard, Thomas, Christian, Hasselblatt, Martin, Paulus, Werner, Hartmann, Christian, Staszewski, Ori, Prinz, Marco, Hench, Juergen, Frank, Stephan, Versleijen-Jonkers, Yvonne M. H., Weidema, Marije E., Mentzel, Thomas, Griewank, Klaus, de Alava, Enrique ORCID: 0000-0001-8400-046X, Martin, Juan Diaz, Gastearena, Miguel A. Idoate, Chang, Kenneth Tou-En, Low, Sharon Yin Yee, Cuevas-Bourdier, Adrian, Mittelbronn, Michel ORCID: 0000-0002-2998-052X, Mynarek, Martin, Rutkowski, Stefan, Schueller, Ulrich, Mautner, Viktor F., Schittenhelm, Jens, Serrano, Jonathan, Snuderl, Matija ORCID: 0000-0003-0752-0917, Buettner, Reinhard, Klingebiel, Thomas, Buslei, Rolf, Gessler, Manfred ORCID: 0000-0002-7915-6045, Wesseling, Pieter, Dinjens, Winand N. M., Brandner, Sebastian ORCID: 0000-0002-9821-0342, Jaunmuktane, Zane, Lyskjaer, Iben ORCID: 0000-0003-3446-1182, Schirmacher, Peter, Stenzinger, Albrecht, Brors, Benedikt ORCID: 0000-0001-5940-3101, Glimm, Hanno, Heining, Christoph, Tirado, Oscar M., Sainz-Jaspeado, Miguel, Mora, Jaume, Alonso, Javier ORCID: 0000-0002-6287-8391, del Muro, Xavier Garcia, Moran, Sebastian, Esteller, Manel, Benhamida, Jamal K., Ladanyi, Marc, Wardelmann, Eva, Antonescu, Cristina, Flanagan, Adrienne, Dirksen, Uta, Hohenberger, Peter, Baumhoer, Daniel, Hartmann, Wolfgang, Vokuhl, Christian, Flucke, Uta, Petersen, Iver, Mechtersheimer, Gunhild, Capper, David ORCID: 0000-0003-1945-497X, Jones, David T. W., Froehling, Stefan, Pfister, Stefan M. and von Deimling, Andreas ORCID: 0000-0002-5863-540X (2021). Sarcoma classification by DNA methylation profiling. Nat. Commun., 12 (1). BERLIN: NATURE RESEARCH. ISSN 2041-1723

Lambo, Sander, Groebner, Susanne N., Rausch, Tobias ORCID: 0000-0001-5773-5620, Waszak, Sebastian M., Schmidt, Christin, Gorthi, Aparna, Romero, July Carolina, Mauermann, Monika, Brabetz, Sebastian, Krausert, Sonja, Buchhalter, Ivo, Koster, Jan, Zwijnenburg, Danny A., Sill, Martin, Huebner, Jens-Martin, Mack, Norman, Schwalm, Benjamin, Ryzhova, Marina ORCID: 0000-0001-7206-6365, Hovestadt, Volker, Papillon-Cavanagh, Simon ORCID: 0000-0002-0372-2266, Chan, Jennifer A., Landgraf, Pablo, Ho, Ben, Milde, Till, Witt, Olaf, Ecker, Jonas, Sahm, Felix ORCID: 0000-0001-5441-1962, Sumerauer, David, Ellison, David W., Orr, Brent A., Darabi, Anna, Haberler, Christine, Figarella-Branger, Dominique, Wesseling, Pieter, Schittenhelm, Jens, Remke, Marc, Taylor, Michael D., Gil-da-Costa, Maria J., Lastowska, Maria, Grajkowska, Wieslawa, Hasselblatt, Martin, Hauser, Peter, Pietsch, Torsten, Uro-Coste, Emmanuelle, Bourdeaut, Franck, Masliah-Planchon, Julien, Rigau, Valerie, Alexandrescu, Sanda, Wolf, Stephan, Li, Xiao-Nan, Schuller, Ulrich, Snuderl, Matija ORCID: 0000-0003-0752-0917, Karajannis, Matthias A., Giangaspero, Felice, Jabado, Nada, von Deimling, Andreas ORCID: 0000-0002-5863-540X, Jones, David T. W., Korbel, Jan O., von Hoff, Katja, Lichter, Peter, Huang, Annie, Bishop, Alexander J. R., Pfister, Stefan M., Korshunov, Andrey ORCID: 0000-0002-5257-3623 and Kool, Marcel (2019). The molecular landscape of ETMR at diagnosis and relapse. Nature, 576 (7786). S. 274 - 300. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Nemes, Karolina, Johann, Pascal D., Steinbuegl, Mona, Gruhle, Miriam, Bens, Susanne, Kachanov, Denis, Teleshova, Margarita, Hauser, Peter, Simon, Thorsten ORCID: 0000-0002-3425-8451, Tippelt, Stephan, Eberl, Wolfgang, Chada, Martin, Lopez, Vicente Santa-Maria, Grigull, Lorenz ORCID: 0000-0001-8807-2874, Hernaiz-Driever, Pablo, Eyrich, Matthias ORCID: 0000-0002-8099-5903, Pears, Jane, Milde, Till ORCID: 0000-0002-7267-1052, Reinhard, Harald, Leipold, Alfred, van de Wetering, Marianne, Gil-da-Costa, Maria Joao, Ebetsberger-Dachs, Georg, Kerl, Kornelius, Lemmer, Andreas, Boztug, Heidrun, Furtwaengler, Rhoikos, Kordes, Uwe, Vokuhl, Christian, Hasselblatt, Martin, Bison, Brigitte, Kroencke, Thomas, Melchior, Patrick, Timmermann, Beate, Gerss, Joachim ORCID: 0000-0003-3489-683X, Siebert, Reiner and Fruehwald, Michael C. (2022). Infants and Newborns with Atypical Teratoid Rhabdoid Tumors (ATRT) and Extracranial Malignant Rhabdoid Tumors (eMRT) in the EU-RHAB Registry: A Unique and Challenging Population. Cancers, 14 (9). BASEL: MDPI. ISSN 2072-6694

Pfaff, Elke, El Damaty, Ahmed, Balasubramanian, Gnana Prakash, Blattner-Johnson, Mirjam, Worst, Barbara C., Stark, Sebastian, Witt, Hendrik, Pajtler, Kristian W. ORCID: 0000-0002-3562-6121, van Tilburg, Cornelis M., Witt, Ruth, Milde, Till, Jakobs, Martin, Fiesel, Petra, Fruehwald, Michael C., Driever, Pablo Hernaiz, Thomale, Ulrich W., Schuhmann, Martin U., Metzler, Markus, Bochennek, Konrad, Simon, Thorsten, Duerken, Matthias, Karremann, Michael ORCID: 0000-0002-9961-4752, Knirsch, Stephanie, Ebinger, Martin ORCID: 0000-0002-4229-8058, von Bueren, Andre O., Pietsch, Torsten, Herold-Mende, Christel, Reuss, David E., Kiening, Karl, Lichter, Peter, Eggert, Angelika, Kramm, Christof M., Pfister, Stefan M., Jones, David T. W., Baechli, Heidi and Witt, Olaf (2019). Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience. Eur. J. Cancer, 114. S. 27 - 36. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

Worst, Barbara C., van Tilburg, Cornelis M., Balasubramanian, Gnana Prakash, Fiesel, Petra, Witt, Ruth, Freitag, Angelika, Boudalil, Miream, Previti, Christopher, Wolf, Stephan, Schmidt, Sabine, Chotewutmontri, Sasithorn, Bewerunge-Hudler, Melanie, Schick, Matthias, Schlesner, Matthias ORCID: 0000-0002-5896-4086, Hutter, Barbara ORCID: 0000-0002-9034-0329, Taylor, Lenka, Borst, Tobias, Sutter, Christian, Bartram, Claus R., Milde, Till ORCID: 0000-0002-7267-1052, Pfaff, Elke, Kulozik, Andreas E., von Stackelberg, Arend, Meisel, Roland, Borkhardt, Arndt, Reinhardt, Dirk, Klusmann, Jan-Henning ORCID: 0000-0002-1070-0727, Fleischhack, Gudrun, Tippelt, Stephan, Dirksen, Uta, Juergens, Heribert, Kramm, Christof M., von Bueren, Andre O., Westermann, Frank, Fischer, Matthias, Burkhardt, Birgit, Wossmann, Wilhelm, Nathrath, Michaela, Bielack, Stefan S., Fruehwald, Michael C., Fulda, Simone ORCID: 0000-0002-0459-6417, Klingebiel, Thomas, Koscielniak, Ewa, Schwab, Matthias, Tremmel, Roman ORCID: 0000-0003-1564-0433, Driever, Pablo Hernaiz, Schulte, Johannes H., Brors, Benedikt ORCID: 0000-0001-5940-3101, von Deimling, Andreas ORCID: 0000-0002-5863-540X, Lichter, Peter, Eggert, Angelika, Capper, David ORCID: 0000-0003-1945-497X, Pfister, Stefan M., Jones, David T. W. and Witt, Olaf (2016). Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. Eur. J. Cancer, 65. S. 91 - 102. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

van Tilburg, Cornelis M., Milde, Till, Witt, Ruth, Ecker, Jonas, Hielscher, Thomas, Seitz, Angelika, Schenk, Jens-Peter, Buhl, Juliane L., Riehl, Dennis, Fruhwald, Michael C., Pekrun, Arnulf, Rossig, Claudia, Wieland, Regina, Flotho, Christian, Kordes, Uwe, Gruhn, Bernd, Simon, Thorsten, Linderkamp, Christin, Sahm, Felix ORCID: 0000-0001-5441-1962, Taylor, Lenka, Freitag, Angelika, Burhenne, Jurgen, Foerster, Kathrin I., Meid, Andreas D., Pfister, Stefan M., Karapanagiotou-Schenkel, Irini and Witt, Olaf (2019). Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia. Clin. Epigenetics, 11 (1). LONDON: BMC. ISSN 1868-7083

van Tilburg, Cornelis M., Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P. S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, von Stackelberg, Arend, Kulozik, Andreas E., Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan-Henning ORCID: 0000-0002-1070-0727, Fleischhack, Gudrun, Tippelt, Stephan, von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M., von Bueren, Andre O., Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert ORCID: 0000-0002-2248-323X, Westermann, Frank, Fischer, Matthias, Eggert, Angelika ORCID: 0000-0003-3476-8184, Burkhardt, Birgit, Woessmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Fruehwald, Michael C., Schneider, Dominik T. ORCID: 0000-0001-8153-1601, Brecht, Ines B., Ketteler, Petra, Fulda, Simone ORCID: 0000-0002-0459-6417, Koscielniak, Ewa, Meister, Michael T., Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Ora, Ingrid, Hutter, Caroline, Gerber, Nicolas U., Lohi, Olli, Kazanowska, Bernarda ORCID: 0000-0002-7198-9122, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C. Michel, Milde, Till, Jaeger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix ORCID: 0000-0001-5441-1962, von Deimling, Andreas ORCID: 0000-0002-5863-540X, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T. W., Molenaar, Jan J., Capper, David ORCID: 0000-0003-1945-497X, Pfister, Stefan M. and Witt, Olaf (2021). The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets. Cancer Discov., 11 (11). S. 2764 - 2780. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 2159-8290

van Tilburg, Cornelis Martinus, Milde, Till, Witt, Ruth, Ecker, Jonas, Seitz, Angelika, Schenk, Jens-Peter, Fruehwald, Michael, Pekrun, Arnulf, Roessig, Claudia, Wieland, Regina, Flotho, Christian, Kordes, Uwe, Gruhn, Bernd, Simon, Thorsten, Linderkamp, Christin, Taylor, Lenka, Burhenne, Juergen, Pfister, Stefan M., Karapanagiotou-Schenkel, Irini and Witt, Olaf (2018). Phase 1/2 intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia. J. Clin. Oncol., 36 (15). ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. ISSN 1527-7755