Universität zu Köln

Journal Article

Bar-On, Yotam, Gruell, Henning, Schoofs, Till, Pai, Joy A., Nogueira, Lilian, Butler, Allison L., Millard, Katrina, Lehmann, Clara, Suarez, Isabelle, Oliveira, Thiago Y., Karagounis, Theodora ORCID: 0000-0003-1481-9589, Cohen, Yehuda Z., Wyen, Christoph, Scholten, Stefan, Handl, Lisa, Belblidia, Shiraz, Dizon, Juan P., Vehreschild, Joerg J., Witmer-Pack, Maggi, Shimeliovich, Irina, Jain, Kanika, Fiddike, Kerstin, Seaton, Kelly E., Yates, Nicole L., Horowitz, Jill, Gulick, Roy M., Pfeifer, Nico, Tomaras, Georgia D., Seaman, Michael S., Faetkenheuer, Gerd, Caskey, Marina, Klein, Florian and Nussenzweig, Michel C. (2018). Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals. Nat. Med., 24 (11). S. 1701 - 1710. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-170X

Barnes, Christopher O., Schoofs, Till, Gnanapragasam, Priyanthi N. P., Golijanin, Jovana, Huey-Tubman, Kathryn E., Gruell, Henning, Schommers, Philipp ORCID: 0000-0003-3375-6800, Suh-Toma, Nina, Lee, Yu Erica, Lorenzi, Julio C. Cetrulo, Piechocka-Trocha, Alicja, Scheid, Johannes F., Jr, Anthony P. West, Walker, Bruce D., Seaman, Michael S., Klein, Florian ORCID: 0000-0003-1376-1792, Nussenzweig, Michel C. and Bjorkman, Pamela J. (2022). A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci. Adv., 8 (32). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 2375-2548

Caskey, Marina ORCID: 0000-0003-1727-8693, Klein, Florian, Lorenzi, Julio C. C., Seaman, Michael S., West, Anthony P., Jr., Buckley, Noreen, Kremer, Gisela, Nogueira, Lilian, Braunschweig, Malte, Scheid, Johannes F., Horwitz, Joshua A., Shimeliovich, Irina, Ben-Avraham, Sivan ORCID: 0000-0002-9130-0062, Witmer-Pack, Maggi, Platten, Martin, Lehmann, Clara ORCID: 0000-0002-7042-1578, Burke, Leah A., Hawthorne, Thomas, Gorelick, Robert J., Walker, Bruce D., Keler, Tibor, Gulick, Roy M., Faetkenheuer, Gerd, Schlesinger, Sarah J. and Nussenzweig, Michel C. (2015). Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature, 522 (7557). S. 487 - 504. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Caskey, Marina, Klein, Florian and Nussenzweig, Michel C. (2019). Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic. Nat. Med., 25 (4). S. 547 - 554. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-170X

Caskey, Marina, Klein, Florian and Nussenzweig, Michel C. (2016). FOCUS ON RESEARCH Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy. N. Engl. J. Med., 375 (21). S. 2019 - 2022. WALTHAM: MASSACHUSETTS MEDICAL SOC. ISSN 1533-4406

Caskey, Marina ORCID: 0000-0003-1727-8693, Schoofs, Till, Gruell, Henning, Settler, Allison, Karagounis, Theodora ORCID: 0000-0003-1481-9589, Kreider, Edward F., Murrell, Ben ORCID: 0000-0002-0393-4445, Pfeifer, Nico ORCID: 0000-0002-4647-8566, Nogueira, Lilian, Oliveira, Thiago Y., Learn, Gerald H., Cohen, Yehuda Z., Lehmann, Clara, Gillor, Daniel, Shimeliovich, Irma, Unson-O'Brien, Cecilia, Weiland, Daniela, Robles, Alexander, Kuemmerle, Tim, Wyen, Christoph, Levin, Rebeka, Witmer-Pack, Maggi, Eren, Kemal, Ignacio, Caroline, Kiss, Szilard ORCID: 0000-0003-3433-8432, West, Anthony P., Jr., Mouquet, Hugo ORCID: 0000-0002-4230-610X, Zingman, Barry S., Gulick, Roy M., Keler, Tibor, Bjorkman, Pamela J., Seaman, Michael S., Hahn, Beatrice H., Faetkenheuer, Gerd, Schlesinger, Sarah J., Nussenzweig, Michel C. and Kleine, Florian (2017). Antibody 10-1074 suppresses viremia in HIV-1-infected individuals. Nat. Med., 23 (2). S. 185 - 192. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-170X

Cohn, Lillian B., Silva, Israel T., Oliveira, Thiago Y., Rosales, Rafael A., Parrish, Erica H., Learn, Gerald H., Hahn, Beatrice H., Czartoski, Julie L., McElrath, M. Juliana, Lehmann, Clara ORCID: 0000-0002-7042-1578, Klein, Florian, Caskey, Marina ORCID: 0000-0003-1727-8693, Walker, Bruce D., Siliciano, Janet D., Siliciano, Robert F., Jankovic, Mila and Nussenzweig, Michel C. (2015). HIV-1 Integration Landscape during Latent and Active Infection. Cell, 160 (3). S. 420 - 433. CAMBRIDGE: CELL PRESS. ISSN 1097-4172

Dam, Kim-Marie A., Barnes, Christopher O., Gristick, Harry B., Schoofs, Till, Gnanapragasam, Priyanthi N. P., Nussenzweig, Michel C. and Bjorkman, Pamela J. (2022). HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design. Nat. Commun., 13 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

Freund, Natalia T., Horwitz, Joshua A., Nogueira, Lilian, Sievers, Stuart A., Scharf, Louise, Scheid, Johannes F., Gazumyan, Anna, Liu, Cassie ORCID: 0000-0003-3907-9409, Velinzon, Klara, Goldenthal, Ariel, Sanders, Rogier W., Moore, John P., Bjorkman, Pamela J., Seaman, Michael S., Walker, Bruce D., Klein, Florian and Nussenzweig, Michel C. (2015). A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo. PLoS Pathog., 11 (10). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7374

Gautam, Rajeev, Nishimura, Yoshiaki, Pegu, Amarendra ORCID: 0000-0003-3564-6453, Nason, Martha C., Klein, Florian, Gazumyan, Anna, Golijanin, Jovana, Buckler-White, Alicia, Sadjadpour, Reza, Wang, Keyun, Mankoff, Zachary, Schmidt, Stephen D., Lifson, Jeffrey D., Mascola, John R., Nussenzweig, Michel C. and Martin, Malcolm A. (2016). A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges. Nature, 533 (7601). S. 105 - 117. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Gristick, Harry B., von Boehmer, Lotta ORCID: 0000-0001-8018-1814, West, Anthony P., Jr., Schamber, Michael, Gazumyan, Anna, Golijanin, Jovana, Seaman, Michael S., Faetkenheuer, Gerd, Klein, Florian, Nussenzweig, Michel C. and Bjorkman, Pamela J. (2016). Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nat. Struct. Mol. Biol., 23 (10). S. 906 - 916. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1545-9985

Gruell, Henning, Gunst, Jesper D., Cohen, Yehuda Z., Pahus, Marie H., Malin, Jakob J. ORCID: 0000-0002-2989-0436, Platten, Martin, Millard, Katrina G., Tolstrup, Martin ORCID: 0000-0001-7020-5173, Jones, R. Brad, Alberto, Winnifer D. Conce, Lorenzi, Julio C. C., Oliveira, Thiago Y., Kuemmerle, Tim, Suarez, Isabelle, Unson-O'Brien, Cecilia, Nogueira, Lilian, Olesen, Rikke ORCID: 0000-0002-5157-080X, Ostergaard, Lars ORCID: 0000-0003-2459-0511, Nielsen, Henrik, Lehmann, Clara ORCID: 0000-0002-7042-1578, Nussenzweig, Michel C., Faetkenheuer, Gerd, Klein, Florian ORCID: 0000-0003-1376-1792, Caskey, Marina and Sogaard, Ole S. (2022). Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial. Lancet Microbe, 3 (3). S. E203 - 12. AMSTERDAM: ELSEVIER. ISSN 2666-5247

Horwitz, Joshua A., Halper-Stromberg, Ariel, Mouquet, Hugo ORCID: 0000-0002-4230-610X, Gitlin, Alexander D., Tretiakova, Anna, Eisenreich, Thomas R., Malbec, Marine, Gravemann, Sophia, Billerbeck, Eva, Dorner, Marcus ORCID: 0000-0003-0321-4226, Buening, Hildegard, Schwartz, Olivier, Knops, Elena, Kaiser, Rolf, Seaman, Michael S., Wilson, James M., Rice, Charles M., Ploss, Alexander ORCID: 0000-0001-9322-7252, Bjorkman, Pamela J., Klein, Florian and Nussenzweig, Michel C. (2013). HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc. Natl. Acad. Sci. U. S. A., 110 (41). S. 16538 - 16544. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

Klein, Florian, Nogueira, Lilian, Nishimura, Yoshiaki, Phad, Ganesh, West, Anthony P., Jr., Halper-Stromberg, Ariel, Horwitz, Joshua A., Gazumyan, Anna, Liu, Cassie ORCID: 0000-0003-3907-9409, Eisenreich, Thomas R., Lehmann, Clara ORCID: 0000-0002-7042-1578, Faetkenheuer, Gerd, Williams, Constance, Shingai, Masashi, Martin, Malcolm A., Bjorkman, Pamela J., Seaman, Michael S., Zolla-Pazner, Susan, Hedestam, Gunilla B. Karlsson and Nussenzweig, Michel C. (2014). Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J. Exp. Med., 211 (12). S. 2361 - 2373. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-9538

Lu, Ching-Lan, Pai, Joy A., Nogueira, Lilian, Mendoza, Pilar, Gruell, Henning, Oliveira, Thiago Y., Barton, John, Lorenzi, Julio C. C., Cohen, Yehuda Z., Cohn, Lillian B., Klein, Florian, Caskey, Marina, Nussenzweig, Michel C. and Jankovic, Mila (2018). Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption. Proc. Natl. Acad. Sci. U. S. A., 115 (48). S. E11341 - 8. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

Mayer, Christian T., Nieke, Jan P., Gazumyan, Anna, Cipolla, Melissa ORCID: 0000-0001-8156-2512, Wang, Qiao, Oliveira, Thiago Y., Ramos, Victor ORCID: 0000-0001-7353-3420, Monette, Sebastien, Li, Quan-Zhen, Gershwin, M. Eric, Kashkar, Hamid and Nussenzweig, Michel C. (2020). An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells. Proc. Natl. Acad. Sci. U. S. A., 117 (40). S. 24957 - 24964. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

Mendoza, Pilar, Gruell, Henning, Lu, Ching-Lan, Butler, Allison, Pai, Joy, Nogueira, Lilian, Oliveira, Thiago Y., Lorenzi, Julio C. C., Cohen, Yehuda Z., Millard, Katrina, Unson-O'Brien, Cecille, Belblidia, Shiraz A., Patel, Roshni, Witmer-Pack, Maggi, Schimeliovich, Irina, Jankovic, Mila, Seaman, Michael S., Klein, Florian, Caskey, Marina and Nussenzweig, Michel C. (2018). Combination of HIV-1 Antibodies 3BNC117 and 10-1074 Delays Viral Rebound During Treatment Interruption. Aids Res. Hum. Retrovir., 34. S. 34 - 35. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1931-8405

Mendoza, Pilar, Gruell, Henning, Nogueira, Lilian, Pai, Joy A., Butler, Allison L., Millard, Katrina, Lehmann, Clara, Suarez, Isabelle, Oliveira, Thiago Y., Lorenzi, Julio C. C., Cohen, Yehuda Z., Wyen, Christoph, Kuemmerle, Tim, Karagounis, Theodora ORCID: 0000-0003-1481-9589, Lu, Ching-Lan, Handl, Lisa, Unson-O'Brien, Cecilia, Patel, Roshni, Ruping, Carola, Schlotz, Maike, Witmer-Pack, Maggi, Shimeliovich, Irina, Kremer, Gisela, Thomas, Eleonore, Seaton, Kelly E., Horowitz, Jill, West, Anthony P., Jr., Bjorkman, Pamela J., Tomaras, Georgia D., Gulick, Roy M., Pfeifer, Nico, Faetkenheuer, Gerd, Seaman, Michael S., Klein, Florian, Caskey, Marina and Nussenzweig, Michel C. (2018). Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nature, 561 (7724). S. 479 - 497. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Niessl, Julia ORCID: 0000-0001-8852-1924, Baxter, Amy E., Mendoza, Pilar, Jankovic, Mila, Cohen, Yehuda Z., Butler, Allison L., Lu, Ching-Lan, Dube, Mathieu ORCID: 0000-0002-5522-9019, Shimeliovich, Irina, Gruell, Henning, Klein, Florian, Caskey, Marina, Nussenzweig, Michel C. and Kaufmann, Daniel E. (2020). Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity. Nat. Med., 26 (2). S. 222 - 244. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-170X

Scheid, Johannes F., Horwitz, Joshua A., Bar-On, Yotam, Kreider, Edward F., Lu, Ching-Lan, Lorenzi, Julio C. C., Feldmann, Anna, Braunschweig, Malte, Nogueira, Lilian, Oliveira, Thiago ORCID: 0000-0002-2654-0879, Shimeliovich, Irina, Patel, Roshni, Burke, Leah, Cohen, Yehuda Z., Hadrigan, Sonya, Settler, Allison, Witmer-Pack, Maggi, West, Anthony P., Jr., Juelg, Boris ORCID: 0000-0002-4687-9626, Keler, Tibor, Hawthorne, Thomas, Zingman, Barry, Gulick, Roy M., Pfeifer, Nico ORCID: 0000-0002-4647-8566, Learn, Gerald H., Seaman, Michael S., Bjorkman, Pamela J., Klein, Florian, Schlesinger, Sarah J., Walker, Bruce D., Hahn, Beatrice H., Nussenzweig, Michel C. and Caskey, Marina ORCID: 0000-0003-1727-8693 (2016). HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature, 535 (7613). S. 556 - 573. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Schoofs, Till, Barnes, Christopher O., Suh-Toma, Nina, Golijanin, Jovana, Schommers, Philipp ORCID: 0000-0003-3375-6800, Gruell, Henning, West, Anthony P., Jr., Bach, Franziska, Lee, Yu Erica, Nogueira, Lilian, Georgiev, Ivelin S., Bailer, Robert T., Czartoski, Julie, Mascola, John R., Seaman, Michael S., McElrath, M. Juliana, Doria-Rose, Nicole A., Klein, Florian, Nussenzweig, Michel C. and Bjorkman, Pamela J. (2019). Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. Immunity, 50 (6). S. 1513 - 1539. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

Schoofs, Till, Klein, Florian, Braunschweig, Malte, Kreider, Edward F., Feldmann, Anna, Nogueira, Lilian, Oliveira, Thiago ORCID: 0000-0002-2654-0879, Lorenzi, Julio C. C., Parrish, Erica H., Learn, Gerald H., West, Anthony P., Jr., Bjorkman, Pamela J., Schlesinger, Sarah J., Seaman, Michael S., Czartoski, Julie, McElrath, M. Juliana, Pfeifer, Nico ORCID: 0000-0002-4647-8566, Hahn, Beatrice H., Caskey, Marina ORCID: 0000-0003-1727-8693 and Nussenzweig, Michel C. (2016). HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1. Science, 352 (6288). S. 997 - 1002. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203