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2019
Panfilio, Kristen A. ORCID: 0000-0002-6417-251X, Vargas Jentzsch, Iris M. ORCID: 0000-0003-4527-1560, Benoit, Joshua B. ORCID: 0000-0002-4018-3513, Erezyilmaz, Deniz ORCID: 0000-0001-8416-8561, Suzuki, Yuichiro ORCID: 0000-0002-0957-3564, Colella, Stefano ORCID: 0000-0003-3139-6055, Robertson, Hugh M., Poelchau, Monica F. ORCID: 0000-0002-4584-6056, Waterhouse, Robert M. ORCID: 0000-0003-4199-9052, Ioannidis, Panagiotis ORCID: 0000-0003-0939-6745, Weirauch, Matthew T. ORCID: 0000-0001-7977-9122, Hughes, Daniel S. T., Murali, Shwetha C., Werren, John H. ORCID: 0000-0001-9353-2070, Jacobs, Chris G. C. ORCID: 0000-0002-3128-2288, Duncan, Elizabeth J. ORCID: 0000-0002-1841-504X, Armisén, David, Vreede, Barbara M. I. ORCID: 0000-0002-5023-4601, Baa-Puyoulet, Patrice, Berger, Chloé S., Chang, Chun-che ORCID: 0000-0002-3586-1607, Chao, Hsu, Chen, Mei-Ju M. ORCID: 0000-0001-7768-8905, Chen, Yen-Ta ORCID: 0000-0002-4570-6061, Childers, Christopher P. ORCID: 0000-0002-1253-5550, Chipman, Ariel D. ORCID: 0000-0001-6696-840X, Cridge, Andrew G. ORCID: 0000-0002-1399-5188, Crumière, Antonin J. J. ORCID: 0000-0003-2214-2993, Dearden, Peter K. ORCID: 0000-0001-7790-9675, Didion, Elise M. ORCID: 0000-0002-4987-8901, Dinh, Huyen ORCID: 0000-0003-0336-0362, Doddapaneni, Harsha Vardhan ORCID: 0000-0002-2433-633X, Dolan, Amanda, Dugan, Shannon ORCID: 0000-0003-1482-816X, Extavour, Cassandra G. ORCID: 0000-0003-2922-5855, Febvay, Gérard ORCID: 0000-0002-0654-2340, Friedrich, Markus ORCID: 0000-0002-5622-7920, Ginzburg, Neta, Han, Yi ORCID: 0000-0001-7605-8979, Heger, Peter, Holmes, Christopher J. ORCID: 0000-0001-9612-366X, Horn, Thorsten ORCID: 0000-0001-8181-939X, Hsiao, Yi-min ORCID: 0000-0002-1817-0302, Jennings, Emily C. ORCID: 0000-0002-7687-5319, Johnston, J. Spencer ORCID: 0000-0003-4792-2945, Jones, Tamsin E. ORCID: 0000-0002-0027-0858, Jones, Jeffery W., Khila, Abderrahman ORCID: 0000-0003-0908-483X, Koelzer, Stefan, Kovacova, Viera ORCID: 0000-0003-4581-4254, Leask, Megan, Lee, Sandra L., Lee, Chien-Yueh ORCID: 0000-0002-4304-974X, Lovegrove, Mackenzie R., Lu, Hsiao-ling ORCID: 0000-0002-4029-6470, Lu, Yong, Moore, Patricia J. ORCID: 0000-0001-9802-7217, Munoz-Torres, Monica C. ORCID: 0000-0001-8430-6039, Muzny, Donna M. ORCID: 0000-0002-3055-0359, Palli, Subba R. ORCID: 0000-0002-0873-3247, Parisot, Nicolas ORCID: 0000-0001-5217-8415, Pick, Leslie ORCID: 0000-0002-4505-5107, Porter, Megan L. ORCID: 0000-0001-7985-2887, Qu, Jiaxin ORCID: 0000-0002-1122-9391, Refki, Peter N., Richter, Rose, Rivera-Pomar, Rolando ORCID: 0000-0002-7720-7064, Rosendale, Andrew J. ORCID: 0000-0002-2463-8856, Roth, Siegfried ORCID: 0000-0001-5772-3558, Sachs, Lena, Santos, M. Emília, Seibert, Jan, Sghaier, Essia, Shukla, Jayendra N. ORCID: 0000-0003-1589-1929, Stancliffe, Richard J. ORCID: 0000-0002-6972-9655, Tidswell, Olivia, Traverso, Lucila, van der Zee, Maurijn ORCID: 0000-0002-8728-8646, Viala, Séverine, Worley, Kim C. ORCID: 0000-0002-0282-1000, Zdobnov, Evgeny M., Gibbs, Richard A. and Richards, Stephen ORCID: 0000-0001-8959-5466 (2019). Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome. Genome Biology, 20 (1). London: BioMed Central. ISSN 1474-760X
2018
Höffe, Otfried and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2018). 16. Kant Und Die Biologie Seiner Zeit (§§ 79–81). In: Immanuel Kant: Kritik der Urteilskraft. pp. 259-272. Berlin, Munich/Boston: De Gruyter. ISBN 9783110571875
2017
Pechmann, Matthias ORCID: 0000-0002-0043-906X, Benton, Matthew A ORCID: 0000-0001-7953-0765, Kenny, Nathan J ORCID: 0000-0003-4816-4103, Posnien, Nico ORCID: 0000-0003-0700-5595 and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2017). A novel role for Ets4 in axis specification and cell migration in the spider Parasteatoda tepidariorum. eLife, 6. Cambridge: eLife Sciences Publications. ISSN 2050-084X
2016
Benton, Matthew A., Pechmann, Matthias, Frey, Nadine, Stappert, Dominik, Conrads, Kai H., Chen, Yen-Ta, Stamataki, Evangelia, Pavlopoulos, Anastasios and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2016). Toll Genes Have an Ancestral Role in Axis Elongation. Current Biology, 26 (12). pp. 1609-1615. Cell Press. ISSN 09609822
McGregor, Alistair P., Benton, Matthew A. ORCID: 0000-0001-7953-0765, Kenny, Nathan J., Conrads, Kai H., Roth, Siegfried ORCID: 0000-0001-5772-3558 and Lynch, Jeremy A. (2016). Deep, Staged Transcriptomic Resources for the Novel Coleopteran Models Atrachya menetriesi and Callosobruchus maculatus. PLOS ONE, 11 (12). e0167431. San Francisco, California, US: PLOS / Public Library of Science. ISSN 1932-6203
Misra, Mala, Edmund, Hendia, Ennis, Darragh, Schlueter, Marissa A., Marot, Jessica E., Tambasco, Janet, Barlow, Ida, Sigurbjornsdottir, Sara, Mathew, Renjith, Vallés, Ana Maria, Wojciech, Waldemar, Roth, Siegfried ORCID: 0000-0001-5772-3558, Davis, Ilan, Leptin, Maria and Gavis, Elizabeth R. (2016). A Genome-Wide Screen for Dendritically Localized RNAs Identifies Genes Required for Dendrite Morphogenesis. G3: Genes, genomes, genetics, 6 (8). pp. 2397-2405. Pittsburgh, PA: Genetics Soc. of America. ISSN 2160-1836
Pers, Daniel, Buchta, Thomas, Özüak, Orhan, Wolff, Selma, Pietsch, Jessica M., Memon, Mohammad Bilal, Roth, Siegfried ORCID: 0000-0001-5772-3558 and Lynch, Jeremy A. (2016). Global analysis of dorsoventral patterning in the wasp Nasonia reveals extensive incorporation of novelty in a regulatory network. BMC Biology, 14 (1). Berlin ; Heidelberg: Springer. ISSN 1741-7007
Roth, Siegfried ORCID: 0000-0001-5772-3558 (2016). Hans Meinhardt (1938–2016). Current Biology, 26 (11). R448-R449. Cambridge, Mass.: Cell Press. ISSN 09609822
Stappert, Dominik, Frey, Nadine, von Levetzow, Cornelia and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2016). Genome-wide identification ofTriboliumdorsoventral patterning genes. Development, 143 (13). pp. 2443-2454. Cambridge: The Company of Biologists. ISSN 0950-1991
2015
Moczek, Armin P., Sears, Karen E., Stollewerk, Angelika, Wittkopp, Patricia J., Diggle, Pamela, Dworkin, Ian, Ledon-Rettig, Cristina, Matus, David Q., Roth, Siegfried ORCID: 0000-0001-5772-3558, Abouheif, Ehab, Brown, Federico D., Chiu, Chi-Hua, Cohen, C. Sarah, Tomaso, Anthony W. De, Gilbert, Scott F., Hall, Brian, Love, Alan C., Lyons, Deirdre C., Sanger, Thomas J., Smith, Joel, Specht, Chelsea, Vallejo-Marin, Mario and Extavour, Cassandra G. (2015). The significance and scope of evolutionary developmental biology: a vision for the 21st century. Evolution and development, 17 (3). pp. 198-219. Malden, Mass.: Blackwell Science. ISSN 1520541X
Sachs, Lena, Chen, Yen-Ta, Drechsler, Axel, Lynch, Jeremy A, Panfilio, Kristen A, Lässig, Michael, Berg, Johannes and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2015). Dynamic BMP signaling polarized by Toll patterns the dorsoventral axis in a hemimetabolous insect. eLife, 4. Cambridge: eLife Sciences Publications. ISSN 2050-084X
Schmitt-Engel, Christian, Schultheis, Dorothea, Schwirz, Jonas, Ströhlein, Nadi, Troelenberg, Nicole, Majumdar, Upalparna, Dao, Van Anh, Grossmann, Daniela, Richter, Tobias, Tech, Maike, Dönitz, Jürgen, Gerischer, Lizzy, Theis, Mirko, Schild, Inga, Trauner, Jochen, Koniszewski, Nikolaus D. B., Küster, Elke, Kittelmann, Sebastian, Hu, Yonggang, Lehmann, Sabrina, Siemanowski, Janna, Ulrich, Julia, Panfilio, Kristen A., Schröder, Reinhard, Morgenstern, Burkhard, Stanke, Mario, Buchhholz, Frank, Frasch, Manfred ORCID: 0000-0003-1373-9798, Roth, Siegfried ORCID: 0000-0001-5772-3558, Wimmer, Ernst A., Schoppmeier, Michael, Klingler, Martin and Bucher, Gregor ORCID: 0000-0002-4615-6401 (2015). The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology. Nature Communications, 6 (1). London: Nature Publishing Group UK. ISSN 2041-1723
2014
Özüak, Orhan, Buchta, Thomas, Roth, Siegfried ORCID: 0000-0001-5772-3558 and Lynch, Jeremy A. (2014). Ancient and diverged TGF-β signaling components in Nasonia vitripennis. Development Genes and Evolution, 224 (4-6). pp. 223-233. Berlin ; Heidelberg: Springer. ISSN 0949-944X
Özüak, Orhan, Buchta, Thomas, Roth, Siegfried ORCID: 0000-0001-5772-3558 and Lynch, Jeremy A. (2014). Dorsoventral Polarity of the Nasonia Embryo Primarily Relies on a BMP Gradient Formed without Input from Toll. Current Biology, 24 (20). pp. 2393-2398. Cambridge, Mass.: Cell Press. ISSN 09609822
2013
Buchta, Thomas, Özüak, Orhan, Stappert, Dominik, Roth, Siegfried ORCID: 0000-0001-5772-3558 and Lynch, Jeremy A. (2013). Patterning the dorsal–ventral axis of the wasp Nasonia vitripennis. Developmental Biology, 381 (1). pp. 189-202. Elsevier. ISSN 00121606
Dearden, Peter K., Zeng, Victor, Ewen-Campen, Ben, Horch, Hadley W., Roth, Siegfried ORCID: 0000-0001-5772-3558, Mito, Taro and Extavour, Cassandra G. (2013). Developmental Gene Discovery in a Hemimetabolous Insect: De Novo Assembly and Annotation of a Transcriptome for the Cricket Gryllus bimaculatus. PLOS ONE, 8 (5). e61479. PLOS / Public Library of Science. ISSN 1932-6203
Panfilio, K. A., Oberhofer, G. and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2013). High plasticity in epithelial morphogenesis during insect dorsal closure. Biology Open, 2 (11). pp. 1108-1118. Cambridge: Company of Biologists. ISSN 2046-6390
Panfilio, Kristen A. and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2013). Development: Getting into the Groove, or Evolving off the Rails? Current Biology, 23 (24). R1101-R1103. Cell Press. ISSN 09609822
Vreede, Barbara MI, Lynch, Jeremy A, Roth, Siegfried ORCID: 0000-0001-5772-3558 and Sucena, Élio (2013). Co-option of a coordinate system defined by the EGFr and Dpp pathways in the evolution of a morphological novelty. EvoDevo, 4 (1). p. 7. London: BioMed Central. ISSN 2041-9139
2012
Baffet, Alexandre D., Benoit, Béatrice, Januschke, Jens, Audo, Jennifer, Gourhand, Vanessa, Roth, Siegfried ORCID: 0000-0001-5772-3558, Guichet, Antoine and Bettencourt-Dias, Monica (2012). Drosophila tubulin-binding cofactor B is required for microtubule network formation and for cell polarity. Molecular Biology of the Cell, 23 (18). pp. 3591-3601. Bethesda, Md.: American Society for Cell Biology. ISSN 1059-1524
Roth, Siegfried ORCID: 0000-0001-5772-3558 and Lynch, Jeremy (2012). Axis Formation: Microtubules Push in the Right Direction. Current Biology, 22 (13). R537-R539. Cell Press. ISSN 09609822
Roth, Siegfried ORCID: 0000-0001-5772-3558 and Lynch, Jeremy (2012). Does the Bicoid Gradient Matter? Cell, 149 (3). pp. 511-512. Cambridge, Mass.: Cell Press. ISSN 00928674
Roth, Siegfried ORCID: 0000-0001-5772-3558 and Panfilio, K. A. (2012). Making Waves for Segments. Science, 336 (6079). pp. 306-307. Science / AAAS, American Association for the Advancement of Science. ISSN 0036-8075
Technau, Martin, Knispel, Meike and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2012). Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila. Development Genes and Evolution, 222 (1). pp. 1-17. Springer. ISSN 0949-944X
2011
Ewen-Campen, Ben, Shaner, Nathan, Panfilio, Kristen A, Suzuki, Yuichiro, Roth, Siegfried ORCID: 0000-0001-5772-3558 and Extavour, Cassandra G (2011). The maternal and early embryonic transcriptome of the milkweed bug Oncopeltus fasciatus. BMC Genomics, 12 (1). Berlin ; Heidelberg: Springer. ISSN 1471-2164
Kopp, Artyom, Lynch, Jeremy A., Özüak, Orhan, Khila, Abderrahman, Abouheif, Ehab, Desplan, Claude and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2011). The Phylogenetic Origin of oskar Coincided with the Origin of Maternally Provisioned Germ Plasm and Pole Cells at the Base of the Holometabola. PLoS Genetics, 7 (4). e1002029. San Francisco, Calif.: Public Library of Science. ISSN 1553-7404
Lynch, J. A. and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2011). The evolution of dorsal-ventral patterning mechanisms in insects. Genes & Development, 25 (2). pp. 107-118. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. ISSN 0890-9369
Roth, Siegfried ORCID: 0000-0001-5772-3558 (2011). Evolution und Fortschritt Zum Problem der Höherentwicklung in der organischen Evolution. In: Zweck und Natur, pp. 195-247. Paderborn: Wilhelm Fink. ISBN 9783846749791
Roth, Siegfried ORCID: 0000-0001-5772-3558 (2011). Mathematics and biology: a Kantian view on the history of pattern formation theory. Development Genes and Evolution, 221 (5-6). pp. 255-279. Berlin ; Heidelberg: Springer. ISSN 0949-944X
2010
Lynch, Jeremy A., Peel, Andrew D., Drechsler, Axel, Averof, Michalis and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2010). EGF Signaling and the Origin of Axial Polarity among the Insects. Current Biology, 20 (11). pp. 1042-1047. Cambridge, Mass: Cell Press. ISSN 09609822
Nunes da Fonseca, Rodrigo, van der Zee, Maurijn and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2010). Evolution of extracellular Dpp modulators in insects: The roles of tolloid and twisted-gastrulation in dorsoventral patterning of the Tribolium embryo. Developmental Biology, 345 (1). pp. 80-93. Amsterdam [u.a.]: Elsevier. ISSN 00121606
Panfilio, Kristen A. and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2010). Epithelial reorganization events during late extraembryonic development in a hemimetabolous insect. Developmental Biology, 340 (1). pp. 100-115. Amsterdam [u.a.]: Elsevier. ISSN 00121606
Rousso, T., Lynch, J., Yogev, S., Roth, Siegfried ORCID: 0000-0001-5772-3558, Schejter, E. D. and Shilo, B.-Z. (2010). Generation of distinct signaling modes via diversification of the Egfr ligand-processing cassette. Development, 137 (20). pp. 3427-3437. Cambridge: The Company of Biologists. ISSN 0950-1991
2009
Fonseca, Rodrigo Nunes da, Lynch, Jeremy A and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2009). Evolution of axis formation: mRNA localization, regulatory circuits and posterior specification in non-model arthropods. Current Opinion in Genetics & Development, 19 (4). pp. 404-411. Amsterdam [u.a.]: Elsevier. ISSN 0959437X
Roth, Siegfried ORCID: 0000-0001-5772-3558 and Lynch, J. A. (2009). Symmetry Breaking During Drosophila Oogenesis. Cold Spring Harbor Perspectives in Biology, 1 (2). a001891-a001891. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. ISSN 1943-0264
2008
Gervais, L., Claret, S., Januschke, J., Roth, Siegfried ORCID: 0000-0001-5772-3558 and Guichet, A. (2008). PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyte. Development, 135 (23). pp. 3829-3838. Cambridge: The Company of Biologists. ISSN 0950-1991
Nunes da Fonseca, Rodrigo, von Levetzow, Cornelia, Kalscheuer, Patrick, Basal, Abidin, van der Zee, Maurijn and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2008). Self-Regulatory Circuits in Dorsoventral Axis Formation of the Short-Germ Beetle Tribolium castaneum. Developmental Cell, 14 (4). pp. 605-615. Cambridge, Mass: Cell Press. ISSN 15345807
Roth, Siegfried ORCID: 0000-0001-5772-3558 (2008). The genome of the model beetle and pest Tribolium castaneum. Nature, 452 (7190). pp. 949-955. London; u.a.: Nature Publ. Group. ISSN 0028-0836
Roth, Siegfried ORCID: 0000-0001-5772-3558 and Hartenstein, Volker (2008). Development of Tribolium castaneum. Development Genes and Evolution, 218 (3-4). pp. 115-118. Berlin ; Heidelberg: Springer. ISSN 0949-944X
Technau, Martin and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2008). The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis. Fly, 2 (2). pp. 82-91. London; u.a.: Taylor & Francis. ISSN 1933-6934
Van der Zee, Maurijn, da Fonseca, Rodrigo Nunes and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2008). TGFβ signaling in Tribolium: vertebrate-like components in a beetle. Development Genes and Evolution, 218 (3-4). pp. 203-213. Berlin ; Heidelberg : Springer: Springer. ISSN 0949-944X
2007
Shravage, B. V., Altmann, G., Technau, M. and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2007). The role of Dpp and its inhibitors during eggshell patterning in Drosophila. Development, 134 (12). pp. 2261-2271. Cambridge: The Company of Biologists. ISSN 0950-1991
2006
Bokel, C. and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2006). Drosophila Cornichon acts as cargo receptor for ER export of the TGF -like growth factor Gurken. Development, 133 (3). pp. 459-470. Cambridge: The Company of Biologists. ISSN 0950-1991
Prothmann, Christian, Armstrong, Neil J., Roth, Siegfried ORCID: 0000-0001-5772-3558 and Rupp, Ralph A.W. (2006). Vertebrate rel proteins exhibit dorsal-like activities in earlyDrosophila embryogenesis. Developmental Dynamics, 235 (4). pp. 949-957. New York, NY [u.a.]: Wiley. ISSN 1058-8388
Zee, M. v. d., Stockhammer, O., Levetzow, C. v., Fonseca, R. N. d. and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2006). Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect. Proceedings of the National Academy of Sciences, 103 (44). pp. 16307-16312. Washington, DC: NAS. ISSN 0027-8424
2005
Handel, Klaus, Basal, Abidin, Fan, Xiang and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2005). Tribolium castaneum twist: gastrulation and mesoderm formation in a short-germ beetle. Development Genes and Evolution, 215 (1). pp. 13-31. Berlin ; Heidelberg: Springer. ISSN 0949-944X
Moussian, Bernard and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2005). Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient. Current Biology, 15 (21). R887-R899. Cambridge, Mass.: Cell Press. ISSN 09609822
Roth, Siegfried ORCID: 0000-0001-5772-3558 (2005). Bicoid and Dorsal: Two transcriptions factor gradients which specify cell fates in the early Drosophila embryo. In: Key Experiments in Practical Developmental Biology, pp. 231-254. Cambridge: Cambridge University Press. ISBN 9780511546204
Roth, Siegfried ORCID: 0000-0001-5772-3558 (2005). The role of EGF and TGF-beta signaling in patterning of follicle cells during Drosophila oogenesis. Developmental Biology, 283 (2). p. 597. Amsterdam [u.a.]: Elsevier. ISSN 00121606
van der Zee, Maurijn, Berns, Nicola and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2005). Distinct Functions of the Tribolium zerknu¨llt Genes in Serosa Specification and Dorsal Closure. Current Biology, 15 (7). pp. 624-636. Cambridge, Mass.: Cell Press. ISSN 09609822
2002
Peri, Francesca, Technau, Martin and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2002). Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila. Development, 129 (12). pp. 2965-2975. Cambridge: The Company of Biologists. ISSN 0950-1991
2001
Guichet, Antoine, Peri, Francesca and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2001). Stable Anterior Anchoring of the Oocyte Nucleus Is Required to Establish Dorsoventral Polarity of the Drosophila Egg. Developmental Biology, 237 (1). pp. 93-106. San Diego, Calif.: Elsevier. ISSN 00121606
0214
Roth, Siegfried ORCID: 0000-0001-5772-3558 (0214). Kant, Polanyi, and Molecular Biology. In: Kant’s Theory of Biology, Berlin, Munich, Boston: De Gruyter. ISBN 978-3-11-022578-5