Universität zu Köln

Galldiks, Norbert ORCID: 0000-0002-2485-1796, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Werner, Jan-Michael ORCID: 0000-0001-7147-4594, Ceccon, Garry, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2020). Molecular imaging and advanced MRI findings following immunotherapy in patients with brain tumors. Expert Rev. Anticancer Ther, 20 (1). S. 9 - 16. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-8328

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Abstract

Introduction: Currently, immunotherapy using vaccination strategies or oncolytic virus approaches, cell-based immunotherapy, and the blockade of immune checkpoints are under evaluation in patients with brain cancer. Here we summarize clinically significant imaging findings such as treatment-related changes detected by advanced neuroimaging techniques following the most suitable immunotherapy options currently used in neuro-oncology. We, furthermore, provide an overview of how these advanced imaging techniques may help to overcome shortcomings of standard MRI in the assessment and follow-up of patients with brain cancer. Areas covered: The current literature on neuroimaging for immunotherapy in the field of brain tumors, with a focus on gliomas and brain metastases is summarized. Expert commentary: Data suggest that imaging parameters primarily derived from amino acid PET, diffusion- and perfusion-weighted MRI, or MR spectroscopy are particularly helpful for the evaluation of treatment response and provide valuable information for the differentiation of treatment-induced changes from actual brain tumor progression following various immunotherapy approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Werner, Jan-Michael UNSPECIFIED orcid.org/0000-0001-7147-4594 UNSPECIFIED Ceccon, Garry UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-124081
DOI:	10.1080/14737140.2020.1705788
Journal or Publication Title:	Expert Rev. Anticancer Ther
Volume:	20
Number:	1
Page Range:	S. 9 - 16
Date:	2020
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-8328
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; RESPONSE ASSESSMENT; GENE-EXPRESSION; GLIOBLASTOMA; THERAPY; PET; PSEUDOPROGRESSION; RECOMMENDATIONS; METASTASIS; PROSPECTS Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12408