Universität zu Köln

Haertle, Larissa ORCID: 0000-0002-3927-9163, Mueller, Tobias, Lardenoije, Roy, Maierhofer, Anna, Dittrich, Marcus, Riemens, Renzo J. M., Stora, Samantha, Roche, Mathilde, Leber, Markus, Riedel-Heller, Steffi, Wagner, Michael ORCID: 0000-0003-2589-6440, Scherer, Martin, Ravel, Aime, Mircher, Clotilde, Cieuta-Walti, Cecile, Durand, Sophie, van de Hove, Daniel L. A., Hoffmann, Per, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Haaf, Thomas, El Hajj, Nady and Megarbane, Andre (2019). Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer's disease-related dysregulation. Clin. Epigenetics, 11 (1). LONDON: BMC. ISSN 1868-7083

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Abstract

Background: Trisomy 21 (T21) is associated with intellectual disability that ranges from mild to profound with an average intellectual quotient of around 50. Furthermore, T21 patients have a high risk of developing Alzheimer's disease (AD) early in life, characterized by the presence of senile plaques of amyloid protein and neurofibrillary tangles, leading to neuronal loss and cognitive decline. We postulate that epigenetic factors contribute to the observed variability in intellectual disability, as well as at the level of neurodegeneration seen in T21 individuals. Materials and Methods: A genome-wide DNA methylation study was performed using Illumina Infinium (R) MethylationEPIC BeadChips on whole blood DNA of 3 male T21 patients with low IQ, 8 T21 patients with high IQ (4 males and 4 females), and 21 age- and sex-matched control samples (12 males and 9 females) in order to determine whether DNA methylation alterations could help explain variation in cognitive impairment between individuals with T21. In view of the increased risk of developing AD in T21 individuals, we additionally investigated the T21-associated sites in published blood DNA methylation data from the AgeCoDe cohort (German study on Ageing, Cognition, and Dementia). AgeCoDe represents a prospective longitudinal study including non-demented individuals at baseline of which a part develops AD dementia at follow-up. Results: Two thousand seven hundred sixteen differentially methylated sites and regions discriminating T21 and healthy individuals were identified. In the T21 high and low IQ comparison, a single CpG located in the promoter of PELI1 was differentially methylated after multiple testing adjustment. For the same contrast, 69 differentially methylated regions were identified. Performing a targeted association analysis for the significant T21-associated CpG sites in the AgeCoDe cohort, we found that 9 showed significant methylation differences related to AD dementia, including one in the ADAM10 gene. This gene has previously been shown to play a role in the prevention of amyloid plaque formation in the brain. Conclusion: The differentially methylated regions may help understand the interaction between methylation alterations and cognitive function. In addition, ADAM10 might be a valuable blood-based biomarker for at least the early detection of AD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haertle, Larissa UNSPECIFIED orcid.org/0000-0002-3927-9163 UNSPECIFIED Mueller, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Lardenoije, Roy UNSPECIFIED UNSPECIFIED UNSPECIFIED Maierhofer, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Dittrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemens, Renzo J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stora, Samantha UNSPECIFIED UNSPECIFIED UNSPECIFIED Roche, Mathilde UNSPECIFIED UNSPECIFIED UNSPECIFIED Leber, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel-Heller, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ravel, Aime UNSPECIFIED UNSPECIFIED UNSPECIFIED Mircher, Clotilde UNSPECIFIED UNSPECIFIED UNSPECIFIED Cieuta-Walti, Cecile UNSPECIFIED UNSPECIFIED UNSPECIFIED Durand, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED van de Hove, Daniel L. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Per UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Haaf, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED El Hajj, Nady UNSPECIFIED UNSPECIFIED UNSPECIFIED Megarbane, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-124292
DOI:	10.1186/s13148-019-0787-x
Journal or Publication Title:	Clin. Epigenetics
Volume:	11
Number:	1
Date:	2019
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1868-7083
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENOME-WIDE ASSOCIATION; DOWN-SYNDROME; DNA METHYLATION; EPIGENETIC DYSREGULATION; INTELLECTUAL DISABILITY; METAANALYSIS; CHILDREN; DEMENTIA; IMMUNITY; RECEPTOR Multiple languages Oncology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12429