Universität zu Köln

Eich, Marie-Lisa ORCID: 0000-0002-8601-4598, Chaux, Alcides ORCID: 0000-0002-5824-9867, Rodriguez, Maria Angelica Mendoza, Guner, Gunes ORCID: 0000-0002-7338-1524, Taheri, Diana, Pena, Maria Del Carmen Rodriguez, Sharma, Rajni, Allaf, Mohamad E. and Netto, George J. (2020). Tumour immune microenvironment in primary and metastatic papillary renal cell carcinoma. Histopathology, 76 (3). S. 423 - 433. HOBOKEN: WILEY. ISSN 1365-2559

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Abstract

Aims Among renal cell carcinoma (RCC) the tumour immune microenvironment has been best characterised in clear cell RCC. In this study we investigated the expression of several immune markers, including PD-L1, FoxP3 and CD8 in primary and metastatic papillary RCC. Methods and results Three tissue microarrays were constructed from 78 cases with primary papillary RCC and paired metastatic tumour (24 cases) from 78 patients treated between 1982 and 2014. Immunohistochemistry analysis was performed using commercially available antibodies for PD-L1 (clone E1L3N), FoxP3, CD8 and Ki-67. Markers expression level in tumour and/or associated immune cells was analysed by tissue type (non-tumour versus primary tumour versus metastatic tumour) and correlated to clinicopathological features and outcome. Conclusion We found PD-L1 expression in up to one-quarter of primary and metastatic papillary RCC. On univariate analysis, CD8/FoxP3 ratio >1 was associated with favourable outcome, whereas papillary RCCs with high numbers of dual CD8/Ki-67-positive lymphocytes showed an increased likelihood for tumour progression and overall and cancer-related mortality. The association of CD8/FoxP3 ratio >1 and high count of CD8/Ki-67 with outcome remained significant on multivariate analysis when adjusting for stage, grade and patient's age.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eich, Marie-Lisa UNSPECIFIED orcid.org/0000-0002-8601-4598 UNSPECIFIED Chaux, Alcides UNSPECIFIED orcid.org/0000-0002-5824-9867 UNSPECIFIED Rodriguez, Maria Angelica Mendoza UNSPECIFIED UNSPECIFIED UNSPECIFIED Guner, Gunes UNSPECIFIED orcid.org/0000-0002-7338-1524 UNSPECIFIED Taheri, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Pena, Maria Del Carmen Rodriguez UNSPECIFIED UNSPECIFIED UNSPECIFIED Sharma, Rajni UNSPECIFIED UNSPECIFIED UNSPECIFIED Allaf, Mohamad E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Netto, George J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-124582
DOI:	10.1111/his.13987
Journal or Publication Title:	Histopathology
Volume:	76
Number:	3
Page Range:	S. 423 - 433
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2559
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REGULATORY T-CELLS; INFILTRATING LYMPHOCYTES; SURVIVAL; CANCER; FREQUENCY; PD-1; CD8 Multiple languages Cell Biology; Pathology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12458