Zivanovic, Jasmina, Kouroussis, Emilia, Kohl, Joshua B., Adhikari, Bikash, Bursac, Biljana, Schott-Roux, Sonia, Petrovic, Dunja, Miljkovic, Jan Lj., Thomas-Lopez, Daniel, Jung, Youngeun, Miler, Marko ORCID: 0000-0002-8366-3138, Mitchell, Sarah, Milosevic, Verica, Gomes, Jose Eduardo ORCID: 0000-0001-7264-9448, Benhar, Moran ORCID: 0000-0002-7094-3456, Gonzales-Zorn, Bruno, Ivanovic-Burmazovic, Ivana, Torregrossa, Roberta, Mitchell, James R., Whiteman, Matthew ORCID: 0000-0002-6583-6779, Schwarz, Guenter, Snyder, Solomon H., Paul, Bindu D., Carroll, Kate S. and Filipovic, Milos R. (2019). Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Cell Metab., 30 (6). S. 1152 - 1184. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

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Abstract

Life on Earth emerged in a hydrogen sulfide (H2S)-rich environment eons ago and with it protein persulfidation mediated by H2S evolved as a signaling mechanism. Protein persulfidation (S-sulfhydration) is a post-translational modification of reactive cysteine residues, which modulate protein structure and/or function. Persulfides are difficult to label and study due to their reactivity and similarity with cysteine. Here, we report a facile strategy for chemoselective persulfide bioconjugation using dimedone-based probes, to achieve highly selective, rapid, and robust persulfide labeling in biological samples with broad utility. Using this method, we show persulfidation is an evolutionarily conserved modification and waves of persulfidation are employed by cells to resolve sulfenylation and prevent irreversible cysteine overoxidation preserving protein function. We report an age-associated decline in persulfidation that is conserved across evolutionary boundaries. Accordingly, dietary or pharmacological interventions to increase persulfidation associate with increased longevity and improved capacity to cope with stress stimuli.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Zivanovic, JasminaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kouroussis, EmiliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohl, Joshua B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adhikari, BikashUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bursac, BiljanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schott-Roux, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petrovic, DunjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miljkovic, Jan Lj.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomas-Lopez, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, YoungeunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miler, MarkoUNSPECIFIEDorcid.org/0000-0002-8366-3138UNSPECIFIED
Mitchell, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milosevic, VericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomes, Jose EduardoUNSPECIFIEDorcid.org/0000-0001-7264-9448UNSPECIFIED
Benhar, MoranUNSPECIFIEDorcid.org/0000-0002-7094-3456UNSPECIFIED
Gonzales-Zorn, BrunoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivanovic-Burmazovic, IvanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torregrossa, RobertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mitchell, James R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whiteman, MatthewUNSPECIFIEDorcid.org/0000-0002-6583-6779UNSPECIFIED
Schwarz, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snyder, Solomon H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paul, Bindu D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carroll, Kate S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Filipovic, Milos R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-124827
DOI: 10.1016/j.cmet.2019.10.007
Journal or Publication Title: Cell Metab.
Volume: 30
Number: 6
Page Range: S. 1152 - 1184
Date: 2019
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1932-7420
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IN-DEPTH ANALYSIS; HYDROGEN-SULFIDE; SULFENIC ACID; SUPEROXIDE-DISMUTASE; CYSTEINE OXIDATION; REDOX PROTEOMICS; PROTEIN; H2S; MECHANISMS; BIOLOGYMultiple languages
Cell Biology; Endocrinology & MetabolismMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/12482

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