Universität zu Köln

Gorges, Martin, Kunz, Martin S., Mueller, Hans-Peter, Liepelt-Scarfone, Inga, Storch, Alexander, Dodel, Richard, Hilker-Roggendorf, Ruediger, Berg, Daniela, Kalbe, Elke, Braak, Heiko, Del Tredici, Kelly ORCID: 0000-0002-9130-7838, Baudrexel, Simon, Huppertz, Hans-Juergen, Kassubek, Jan ORCID: 0000-0002-7106-9270, Mollenhauer, B., Schulz, J., Spottke, A., Storch, A. and Wittchen, H. -U. (2020). Longitudinal brain atrophy distribution in advanced Parkinson's disease: What makes the difference in cognitive status converters? Hum. Brain Mapp., 41 (6). S. 1416 - 1435. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

We investigated the brain atrophy distribution pattern and rate of regional atrophy change in Parkinson's disease (PD) in association with the cognitive status to identify the morphological characteristics of conversion to mild cognitive impairment (MCI) and dementia (PDD). T1-weighted longitudinal 3T MRI data (up to four follow-up assessments) from neuropsychologically well-characterized advanced PD patients (n = 172, 8.9 years disease duration) and healthy elderly controls (n = 85) enrolled in the LANDSCAPE study were longitudinally analyzed using a linear mixed effect model and atlas-based volumetry and cortical thickness measures. At baseline, PD patients presented with cerebral atrophy and cortical thinning including striatum, temporoparietal regions, and primary/premotor cortex. The atrophy was already observed in cognitively normal PD patients (PD-N) and was considerably more pronounced in cognitively impaired PD patients. Linear mixed effect modeling revealed almost similar rates of atrophy change in PD and controls. The group comparison at baseline between those PD-N whose cognitive performance remained stable (n = 42) and those PD-N patients who converted to MCI/PDD (converter cPD-N, n = 26) indicated suggested cortical thinning in the anterior cingulate cortex in cPD-N patients which was correlated with cognitive performance. Our results suggest that cortical brain atrophy has been already expanded in advanced PD patients without overt cognitive deficits while atrophy progression in late disease did not differ from normal aging regardless of the cognitive status. It appears that cortical atrophy begins early and progresses already in the initial disease stages emphasizing the need for therapeutic interventions already at disease onset.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gorges, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunz, Martin S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Hans-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodel, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilker-Roggendorf, Ruediger UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Braak, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Del Tredici, Kelly UNSPECIFIED orcid.org/0000-0002-9130-7838 UNSPECIFIED Baudrexel, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Huppertz, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, Jan UNSPECIFIED orcid.org/0000-0002-7106-9270 UNSPECIFIED Mollenhauer, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittchen, H. -U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-124903
DOI:	10.1002/hbm.24884
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	41
Number:	6
Page Range:	S. 1416 - 1435
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORTICAL THICKNESS; DIAGNOSTIC-CRITERIA; TASK-FORCE; DEMENTIA; IMPAIRMENT; BIOMARKERS; PATHOLOGY; RESERVE Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12490