Universität zu Köln

Ackermann, Sandra and Fischer, Matthias (2019). Telomere Maintenance in Pediatric Cancer. Int. J. Mol. Sci., 20 (23). BASEL: MDPI. ISSN 1422-0067

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Abstract

Telomere length has been proposed as a biomarker of biological age and a risk factor for age-related diseases and cancer. Substantial progress has been made in recent decades in understanding the complex molecular relationships in this research field. However, the majority of telomere studies have been conducted in adults. The data on telomere dynamics in pediatric cancers is limited, and interpretation can be challenging, especially in cases where results are contrasting to those in adult entities. This review describes recent advances in the molecular characterization of structure and function of telomeres, regulation of telomerase activity in cancer pathogenesis in general, and highlights the key advances that have expanded our views on telomere biology in pediatric cancer, with special emphasis on the central role of telomere maintenance in neuroblastoma. Furthermore, open questions in the field of telomere maintenance research are discussed in the context of recently published literature.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ackermann, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-125673
DOI:	10.3390/ijms20235836
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	20
Number:	23
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TERT PROMOTER MUTATIONS; MESSENGER-RNA EXPRESSION; CENTRAL-NERVOUS-SYSTEM; LOW-GRADE GLIOMAS; REVERSE-TRANSCRIPTASE; HUMAN-CELLS; SURVEILLANCE EPIDEMIOLOGY; CATALYTIC SUBUNIT; GENOMIC LANDSCAPE; PROGNOSTIC-FACTOR Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12567