Universität zu Köln

Neesgaard, Bastian, Pelchen-Matthews, Annegret ORCID: 0000-0002-0994-5655, Ryom, Lene, Florence, Eric, Peters, Lars, Roen, Ashley, Svedhem, Veronika, Clarke, Amanda, Benfield, Thomas ORCID: 0000-0003-0698-9385, Mitsura, Viktar, Moreno, Santiago, Beniowski, Marek, Begovac, Josip, Matulionyte, Raimonda, Trofimova, Tatyana, Elbirt, Daniel, Kundro, Mariana, Vullo, Vincenzo, Behrens, Georg, Staub, Therese, Ragone, Leigh, Vannappagari, Vani, Lundgren, Jens, Mocroft, Amanda, Schmied, B., Zangerle, R., Karpov, I., Vassilenko, A., Paduto, D., Clumeck, N., De Wit, S., Delforge, M., Vandekerckhove, L., Hadziosmanovic, V., Machala, L., Jilich, D., Sedlacek, D., Kronborg, G., Benfield, T., Gerstoft, J., Katzenstein, T., Pedersen, C., Johansen, I. S., Ostergaard, L., Wiese, L., Moller, N. F., Nielsen, L. N., Zilmer, K., Smidt, Jelena, Ristola, M., Aho, I., Viard, J. -P., Girard, P. -M., Pradier, C., Fontas, E., Duvivier, C., Rockstroh, J., Degen, O., Stellbrink, H. J., Stefan, C., Goethe, J. W., Bogner, J., Faetkenheuer, G., Chkhartishvili, N., Sambatakou, H., Adamis, G., Paissios, N., Szlavik, J., Gottfredsson, M., Mulcahy, F., Yust, I., Turner, D., Burke, M., Shahar, E., Hassoun, G., Elinav, H., Haouzi, M., Sthoeger, Z. M., Monforte, A. D'Arminio, Esposito, R., Mazeu, I., Mussini, C., Mazzotta, F., Gabbuti, A., Lichtner, M., Zaccarelli, M., Antinori, A., Acinapura, R., Plazzi, M., Lazzarin, A., Castagna, A., Gianotti, N., Galli, M., Ridolfo, A., Rozentale, B., Uzdaviniene, V., Hemmer, R., Reiss, P., Reikvam, D. H., Maeland, A., Bruun, J., Knysz, B., Gasiorowski, J., Inglot, M., Bakowska, E., Flisiak, R., Grzeszczuk, A., Parczewski, M., Maciejewska, K., Aksak-Was, B., Mularska, E., Smiatacz, T., Gensing, M., Jablonowska, E., Kamerys, J., Wojcik, K., Mozer-Lisewska, I., Rozplochowski, B., Caldeira, L., Mansinho, K., Maltez, F., Radoi, R., Oprea, C., Panteleev, A., Panteleev, O., Yakovlev, A., Trofimora, T., Khromova, I., Kuzovatova, E., Borodulina, E., Vdoushkina, E., Miro, J. M., Mallolas, J., Martinez, E., Garcia, F., Blanco, J. L., Laguno, M., Martinez-Rebollar, M., del Campo, S., Clotet, B., Jou, A., Paredes, R., Puig, J., Llibre, J. M., Santos, J. R., Domingo, P., Gutierrez, M., Mateo, G., Sambeat, M. A., Laporte, J. M., Falconer, K., Thalme, A., Sonnerborg, A., Treutiger, C. J., Flamholc, L., Scherrer, A., Weber, R., Cavassini, M., Calmy, A., Furrer, H., Battegay, M., Schmid, P., Kuznetsova, A., Kyselyova, G., Sluzhynska, M., Gazzard, B., Johnson, A. M., Simons, E., Edwards, S., Phillips, A., Johnson, M. A., Orkin, C., Weber, J., Scullard, G., Leen, C., Phillips, A., Cozzi-Lepri, A., Shepherd, L., Amele, S., Karpov, I., Losso, M., Rockstroh, J., Aho, I., Rasmussen, L. D., Svedhem, V., Wandeler, G., Pradier, C., Chkhartishvili, N., Oprea, C., Kowalska, J. D., Guaraldi, G. and Paredes, R. (2019). Uptake and effectiveness of two-drug compared with three-drug antiretroviral regimens among HIV-positive individuals in Europe. Aids, 33 (13). S. 2013 - 2025. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

Full text not available from this repository.

Abstract

Objective: To assess the use of two-drug antiretroviral regimens (2DR) and virologic and immunologic outcomes compared with three-drug regimens (3DR) in the EuroSIDA cohort. Design: Multicentre, prospective cohort study. Methods: Logistic regression was used to analyse the uptake and outcomes among HIV-positive individuals who started or switched to a 2DR compared with those on a 3DR. Virologic outcomes were assessed on-treatment as the proportion of individuals with controlled viral load (<400 copies/ml), or with a composite modified FDA snapshot endpoint (mFDA), with mFDA success defined as controlled viral load at 6 months or 12 months for individuals with a known viral load, no regimen changes, AIDS or death. Immunologic response was defined as a 100 cells/mu l or a 25% increase in CD4(+) cell counts from baseline. Results: Between 1 July 2010 and 31 December 2016, 423 individuals started or switched to a 2DR (eight antiretroviral-naive) and 4347 started a 3DR (566 naive). Individuals on 2DR tended to have suppressed viral load, higher CD4(+) cell counts and more comorbidities at baseline compared with those on 3DR. There were no differences in the proportions of individuals who obtained on-treatment or mFDA success, and no significant differences in the adjusted odds ratios for mFDA success or immunologic responses between the 2DR and 3DR groups at 6 months or 12 months. Conclusion: In routine clinical practice, 2DR were largely used for virologically suppressed individuals with higher cumulative exposure to antiretrovirals and comorbidities. Virologic and immunologic outcomes were similar among those on 2DR or 3DR, although confounding by indication cannot be fully excluded due to the observational nature of the study.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neesgaard, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelchen-Matthews, Annegret UNSPECIFIED orcid.org/0000-0002-0994-5655 UNSPECIFIED Ryom, Lene UNSPECIFIED UNSPECIFIED UNSPECIFIED Florence, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Roen, Ashley UNSPECIFIED UNSPECIFIED UNSPECIFIED Svedhem, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Clarke, Amanda UNSPECIFIED UNSPECIFIED UNSPECIFIED Benfield, Thomas UNSPECIFIED orcid.org/0000-0003-0698-9385 UNSPECIFIED Mitsura, Viktar UNSPECIFIED UNSPECIFIED UNSPECIFIED Moreno, Santiago UNSPECIFIED UNSPECIFIED UNSPECIFIED Beniowski, Marek UNSPECIFIED UNSPECIFIED UNSPECIFIED Begovac, Josip UNSPECIFIED UNSPECIFIED UNSPECIFIED Matulionyte, Raimonda UNSPECIFIED UNSPECIFIED UNSPECIFIED Trofimova, Tatyana UNSPECIFIED UNSPECIFIED UNSPECIFIED Elbirt, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kundro, Mariana UNSPECIFIED UNSPECIFIED UNSPECIFIED Vullo, Vincenzo UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrens, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Staub, Therese UNSPECIFIED UNSPECIFIED UNSPECIFIED Ragone, Leigh UNSPECIFIED UNSPECIFIED UNSPECIFIED Vannappagari, Vani UNSPECIFIED UNSPECIFIED UNSPECIFIED Lundgren, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Mocroft, Amanda UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmied, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zangerle, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karpov, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vassilenko, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paduto, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clumeck, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED De Wit, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Delforge, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vandekerckhove, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hadziosmanovic, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Machala, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jilich, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sedlacek, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kronborg, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Benfield, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerstoft, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Katzenstein, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedersen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Johansen, I. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ostergaard, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiese, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moller, N. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nielsen, L. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zilmer, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smidt, Jelena UNSPECIFIED UNSPECIFIED UNSPECIFIED Ristola, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Aho, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Viard, J. -P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Girard, P. -M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pradier, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fontas, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Duvivier, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Degen, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stellbrink, H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stefan, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goethe, J. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogner, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chkhartishvili, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sambatakou, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Adamis, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paissios, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Szlavik, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottfredsson, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mulcahy, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yust, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Turner, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burke, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shahar, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hassoun, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elinav, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haouzi, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sthoeger, Z. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Monforte, A. D'Arminio UNSPECIFIED UNSPECIFIED UNSPECIFIED Esposito, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mazeu, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mussini, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mazzotta, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gabbuti, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtner, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaccarelli, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antinori, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Acinapura, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Plazzi, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lazzarin, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Castagna, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gianotti, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galli, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ridolfo, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rozentale, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Uzdaviniene, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hemmer, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reiss, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reikvam, D. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maeland, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruun, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knysz, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gasiorowski, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Inglot, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bakowska, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Flisiak, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grzeszczuk, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Parczewski, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maciejewska, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Aksak-Was, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mularska, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smiatacz, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gensing, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jablonowska, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamerys, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wojcik, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mozer-Lisewska, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rozplochowski, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caldeira, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mansinho, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maltez, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Radoi, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oprea, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Panteleev, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Panteleev, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yakovlev, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Trofimora, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Khromova, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuzovatova, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borodulina, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vdoushkina, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Miro, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallolas, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blanco, J. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laguno, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez-Rebollar, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED del Campo, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clotet, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jou, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paredes, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Puig, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Llibre, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Santos, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Domingo, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutierrez, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mateo, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sambeat, M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laporte, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Falconer, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thalme, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sonnerborg, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Treutiger, C. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Flamholc, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherrer, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cavassini, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Calmy, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Furrer, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Battegay, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuznetsova, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kyselyova, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sluzhynska, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gazzard, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Johnson, A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simons, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Edwards, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Phillips, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Johnson, M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Orkin, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scullard, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Phillips, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cozzi-Lepri, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shepherd, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Amele, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karpov, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Losso, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Aho, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rasmussen, L. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Svedhem, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wandeler, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pradier, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chkhartishvili, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oprea, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowalska, J. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guaraldi, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paredes, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-128536
DOI:	10.1097/QAD.0000000000002320
Journal or Publication Title:	Aids
Volume:	33
Number:	13
Page Range:	S. 2013 - 2025
Date:	2019
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1473-5571
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATAZANAVIR/RITONAVIR PLUS LAMIVUDINE; REVERSE-TRANSCRIPTASE INHIBITOR; OPEN-LABEL; RANDOMIZED-TRIAL; NON-INFERIORITY; INFECTED PATIENTS; TRIPLE THERAPY; DUAL THERAPY; EMTRICITABINE; MAINTENANCE Multiple languages Immunology; Infectious Diseases; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/12853