Universität zu Köln

Zhou, Yifei ORCID: 0000-0003-0088-6262, Wang, Xueqing, Song, Mengjiao, He, Zhidong, Cui, Guizhong ORCID: 0000-0001-6394-2773, Peng, Guangdun ORCID: 0000-0002-8586-0637, Dieterich, Christoph, Antebi, Adam, Jing, Naihe ORCID: 0000-0003-1509-6378 and Shen, Yidong (2019). A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing. Nat. Commun., 10. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. Although tissue-specific changes in autophagy and ageing have been extensively explored, the mechanism underlying the inter-tissue regulation of autophagy with ageing is poorly understood. Here, we show that a secreted microRNA, mir-83/miR-29, controls the age-related decrease in macroautophagy across tissues in Caenorhabditis elegans. Upregulated in the intestine by hsf-1/HSF1 with age, mir-83 is transported across tissues potentially via extracellular vesicles and disrupts macroautophagy by suppressing CUP-5/MCOLN, a vital autophagy regulator, autonomously in the intestine as well as non-autonomously in body wall muscle. Mutating mir-83 thereby enhances macroautophagy in different tissues, promoting protein homeostasis and longevity. These findings thus identify a microRNA-based mechanism to coordinate the decreasing macroautophagy in various tissues with age.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhou, Yifei UNSPECIFIED orcid.org/0000-0003-0088-6262 UNSPECIFIED Wang, Xueqing UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Mengjiao UNSPECIFIED UNSPECIFIED UNSPECIFIED He, Zhidong UNSPECIFIED UNSPECIFIED UNSPECIFIED Cui, Guizhong UNSPECIFIED orcid.org/0000-0001-6394-2773 UNSPECIFIED Peng, Guangdun UNSPECIFIED orcid.org/0000-0002-8586-0637 UNSPECIFIED Dieterich, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED Jing, Naihe UNSPECIFIED orcid.org/0000-0003-1509-6378 UNSPECIFIED Shen, Yidong UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130546
DOI:	10.1038/s41467-019-12821-2
Journal or Publication Title:	Nat. Commun.
Volume:	10
Date:	2019
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEAT-SHOCK RESPONSE; EXTRACELLULAR VESICLES; GENE-EXPRESSION; LIFE-SPAN; STRESS; PROTEOSTASIS; PATHWAYS; PROFILE; GROWTH Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13054