Universität zu Köln

Neuhaus, Elisabeth, Weiss, Kilian, Bastkowski, Rene, Koopmann, Jonas, Maintz, David and Giese, Daniel (2019). Accelerated aortic 4D flow cardiovascular magnetic resonance using compressed sensing: applicability, validation and clinical integration. J. Cardiov. Magn. Reson., 21 (1). LONDON: BMC. ISSN 1532-429X

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Abstract

Background Three-dimensional time-resolved phase-contrast cardiovascular magnetic resonance (4D flow CMR) enables the quantification and visualisation of blood flow, but its clinical applicability remains hampered by its long scan time. The aim of this study was to evaluate the use of compressed sensing (CS) with on-line reconstruction to accelerate the acquisition and reconstruction of 4D flow CMR of the thoracic aorta. Methods 4D flow CMR of the thoracic aorta was acquired in 20 healthy subjects using CS with acceleration factors ranging from 4 to 10. As a reference, conventional parallel imaging (SENSE) with acceleration factor 2 was used. Flow curves, net flows, peak flows and peak velocities were extracted from six contours along the aorta. To measure internal data consistency, a quantitative particle trace analysis was performed. Additionally, scan-rescan, inter- and intraobserver reproducibility were assessed. Subsequently, 4D flow CMR with CS factor 6 was acquired in 3 patients with differing aortopathies. The flow patterns resulting from particle trace visualisation were qualitatively analysed. Results All collected data were successfully acquired and reconstructed on-line. The average acquisition time including respiratory navigator efficiency with CS factor 6 was 5:02 +/- 2:23 min while reconstruction took approximately 9 min. For CS factors of 8 or less, mean differences in net flow, peak flow and peak velocity as compared to SENSE were below 2.2 +/- 7.8 ml/cycle, 4.6 +/- 25.2 ml/s and - 7.9 +/- 13.0 cm/s, respectively. For a CS factor of 10 differences reached 5.4 +/- 8.0 ml/cycle, 14.4 +/- 28.3 ml/s and - 4.0 +/- 12.2 cm/s. Scan-rescan analysis yielded mean differences in net flow of - 0.7 +/- 4.9 ml/cycle for SENSE and - 0.2 +/- 8.5 ml/cycle for CS factor of 6. Conclusions A six- to eightfold acceleration of 4D flow CMR using CS is feasible. Up to a CS acceleration rate of 6, no statistically significant differences in measured flow parameters could be observed with respect to the reference technique. Acquisitions in patients with aortopathies confirm the potential to integrate the proposed method in a clinical routine setting, whereby its main benefits are scan-time savings and direct on-line reconstruction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neuhaus, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Kilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bastkowski, Rene UNSPECIFIED UNSPECIFIED UNSPECIFIED Koopmann, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Giese, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-130605
DOI:	10.1186/s12968-019-0573-0
Journal or Publication Title:	J. Cardiov. Magn. Reson.
Volume:	21
Number:	1
Date:	2019
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1532-429X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHASE-CONTRAST MR; TIME; QUANTIFICATION; PATTERNS; RECONSTRUCTION; ENHANCEMENT; COMBINATION; STRATEGIES; IMPACT Multiple languages Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13060