Universität zu Köln

Feng, Chen, Chan, Wilson Cheuk Wing, Lam, Yan, Wang, Xue, Chen, Peikai, Niu, Ben, Ng, Vivian Chor Wing, Yeo, Jia Chi, Stricker, Sigmar, Cheah, Kathryn Song Eng, Koch, Manuel, Mundlos, Stefan, Ng, Huck Hui and Chan, Danny (2019). Lgr5 and Col22a1 Mark Progenitor Cells in the Lineage toward Juvenile Articular Chondrocytes. Stem Cell Rep., 13 (4). S. 713 - 730. CAMBRIDGE: CELL PRESS. ISSN 2213-6711

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Abstract

The synovial joint forms from a pool of progenitor cells in the future region of the joint, the interzone. Expression of Gdf5 and Wnt9a has been used to mark the earliest cellular processes in the formation of the interzone and the progenitor cells. However, lineage specification and progression toward the different tissues of the joint are not well understood. Here, by lineage-tracing studies we identify a population of Lgr5(+) interzone cells that contribute to the formation of cruciate ligaments, synovial membrane, and articular chondrocytes of the joint. This finding is supported by single-cell transcriptome analyses. We show that Col22a1, a marker of early articular chondrocytes, is co-expressed with Lgr5(+ )cells prior to cavitation as an important lineage marker specifying the progression toward articular chondrocytes. Lgr5(+) cells contribute to the repair of a joint defect with the re-establishment of a Col22a1-expressing superficial layer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Feng, Chen UNSPECIFIED UNSPECIFIED UNSPECIFIED Chan, Wilson Cheuk Wing UNSPECIFIED UNSPECIFIED UNSPECIFIED Lam, Yan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Xue UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Peikai UNSPECIFIED UNSPECIFIED UNSPECIFIED Niu, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Ng, Vivian Chor Wing UNSPECIFIED UNSPECIFIED UNSPECIFIED Yeo, Jia Chi UNSPECIFIED UNSPECIFIED UNSPECIFIED Stricker, Sigmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Cheah, Kathryn Song Eng UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mundlos, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ng, Huck Hui UNSPECIFIED UNSPECIFIED UNSPECIFIED Chan, Danny UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-131257
DOI:	10.1016/j.stemcr.2019.08.006
Journal or Publication Title:	Stem Cell Rep.
Volume:	13
Number:	4
Page Range:	S. 713 - 730
Date:	2019
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2213-6711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYNOVIAL JOINT; CARTILAGE FORMATION; EXPRESSION; MORPHOGENESIS; IDENTIFICATION; PATTERN Multiple languages Cell & Tissue Engineering; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13125