Universität zu Köln

Baldermann, Juan Carlos, Hahn, Lisa ORCID: 0000-0003-0167-3947, Dembek, Till A., Kohl, Sina, Kuhn, Jens, Visser-Vandewalle, Veerle, Horn, Andreas ORCID: 0000-0002-0695-6025 and Huys, Daniel (2019). Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus. Brain Sci., 9 (10). BASEL: MDPI. ISSN 2076-3425

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Abstract

Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baldermann, Juan Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Lisa UNSPECIFIED orcid.org/0000-0003-0167-3947 UNSPECIFIED Dembek, Till A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kohl, Sina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Andreas UNSPECIFIED orcid.org/0000-0002-0695-6025 UNSPECIFIED Huys, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132131
DOI:	10.3390/brainsci9100264
Journal or Publication Title:	Brain Sci.
Volume:	9
Number:	10
Date:	2019
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OBSESSIVE-COMPULSIVE DISORDER; ACCUMBENS; SYMPTOMS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13213