Universität zu Köln

Haidl, G., Allam, J. -P., Koehn, F. -M., Haidl, F. and Schuppe, H. -C. (2019). Pharmaceutical treatment of primarily nonhormone-related male fertility disorders. Gynakol. Endokrinol., 17 (4). S. 236 - 245. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1610-2908

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Abstract

In addition to assisted reproductive techniques and surgical procedures, pharmacotherapy represents an important cornerstone in the management of male infertility. A pathophysiologically founded treatment is not only well-established for various forms of hypogonadotrophic hypogonadism and hyperprolactinemia but is also possible for infections and inflammatory lesions of the male genital tract. Antibiotics are effective when specifically prescribed depending on the pathogen and the resistance; moreover, data for non-steroidal anti-inflammatory drugs, glucocorticosteroids, mast cell blockers, and antioxidants are also available. Based on a pathophysiological rationale, disorders of ejaculation and semen transport can be treated with alpha-sympathomimetics, imipramine and brompheniramine; phosphodiesterase-5 inhibitors have proven to be highly effective in erectile dysfunction. In contrast, the therapeutic management of patients with impairment of semen quality without any identifiable underlying cause is much more problematic. Clinical studies using a wide range of different drugs produced inconsistent results or did not reach a sufficient level of evidence. Recent meta-analyses indicated that low-dose administration of anti-estrogens, such as tamoxifen or clomiphene may have limited positive effectiveness; promising results were obtained following treatment with follicle-stimulating hormone. Increasing research activities concern the therapeutic efficacy of antioxidants and trace elements. For the plethora of widely used neutriceuticals, however, adequately controlled clinical studies are lacking.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haidl, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Allam, J. -P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehn, F. -M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haidl, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuppe, H. -C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132389
DOI:	10.1007/s10304-019-00273-2
Journal or Publication Title:	Gynakol. Endokrinol.
Volume:	17
Number:	4
Page Range:	S. 236 - 245
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1610-2908
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAST-CELL BLOCKER; MALE GENITAL-TRACT; MALE-INFERTILITY; SPERM MOTILITY; PREGNANCY RATE; IDIOPATHIC INFERTILITY; OXIDATIVE STRESS; SEMEN PARAMETERS; RECOMBINANT FSH; SEMINAL PLASMA Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13238