Universität zu Köln

Dudeck, Anne, Koeberle, Martin, Goldmann, Oliver, Meyer, Nicole, Dudeck, Jan, Lemmens, Stefanie, Rohde, Manfred, Roldan, Nestor Gonzalez, Dietze-Schwonberg, Kirsten, Orinska, Zane, Medina, Eva, Hendrix, Sven ORCID: 0000-0003-2344-7369, Metz, Martin, Zenclussen, Ana Claudia, von Stebut, Esther and Biedermann, Tilo ORCID: 0000-0002-5352-5105 (2019). Mast cells as protectors of health. J. Allergy Clin. Immunol., 144 (4). S. S4 - 15. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-6825

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Abstract

Mast cells (MCs), which are well known for their effector functions in T(H)2-skewed allergic and also autoimmune inflammation, have become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs, such as the skin or gut. MCs can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T-cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. This review focuses on the beneficial effects of MCs on tissue homeostasis and elimination of toxins or venoms. MCs can enhance pathogen clearance in many bacterial, viral, and parasitic infections, such as through Toll-like receptor 2-triggered degranulation, secretion of antimicrobial cathelicidins, neutrophil recruitment, or provision of extracellular DNA traps. The role of MCs in tumors is more ambiguous; however, encouraging new findings show they can change the tumor microenvironment toward antitumor immunity when adequately triggered. Uterine tissue remodeling by alpha-chymase (mast cell protease [MCP] 5) is crucial for successful embryo implantation. MCP-4 and the tryptase MCP-6 emerge to be protective in central nervous system trauma by reducing inflammatory damage and excessive scar formation, thereby protecting axon growth. Last but not least, proteases, such as carboxypeptidase A, released by Fc epsilon RI-activated MCs detoxify an increasing number of venoms and endogenous toxins. A better understanding of the plasticity of MCs will help improve these advantageous effects and hint at ways to cut down detrimental MC actions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dudeck, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Koeberle, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldmann, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Dudeck, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemmens, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Rohde, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Roldan, Nestor Gonzalez UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietze-Schwonberg, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Orinska, Zane UNSPECIFIED UNSPECIFIED UNSPECIFIED Medina, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Hendrix, Sven UNSPECIFIED orcid.org/0000-0003-2344-7369 UNSPECIFIED Metz, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Zenclussen, Ana Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED von Stebut, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Biedermann, Tilo UNSPECIFIED orcid.org/0000-0002-5352-5105 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-132868
DOI:	10.1016/j.jaci.2018.10.054
Journal or Publication Title:	J. Allergy Clin. Immunol.
Volume:	144
Number:	4
Page Range:	S. S4 - 15
Date:	2019
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	1097-6825
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DENGUE VIRUS-INFECTION; TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; INFLUENZA-A VIRUS; NEUTROPHIL RECRUITMENT; LEISHMANIA-MAJOR; HOST-DEFENSE; T-CELLS; CUTANEOUS LEISHMANIASIS; ANTIMICROBIAL ACTIVITY Multiple languages Allergy; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13286