Universität zu Köln

Randerath, Winfried, Deleanu, Oana Claudia, Schiza, Sophia and Pepin, Jean-Louis (2019). Central sleep apnoea and periodic breathing in heart failure: prognostic significance and treatment options. Eur. Respir. Rev., 28 (153). SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. ISSN 1600-0617

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Abstract

Central sleep apnoea (CSA) including periodic breathing is prevalent in more than one-third of patients with heart failure and is highly and independently associated with poor outcomes. Optimal treatment is still debated and well-conducted studies regarding efficacy and impact on outcomes of available treatment options are limited, particularly in cardiac failure with preserved ejection fraction. While continuous positive airway pressure and oxygen reduce breathing disturbances by 50%, adaptive servoventilation (ASV) normalises breathing disturbances by to controlling the underlying mechanism of CSA. Results are contradictory regarding impact of ASV on hard outcomes. Cohorts and registry studies show survival improvement under ASV, while secondary analyses of the large SERVE-HF randomised trial showed an excess mortality in cardiac failure with reduced ejection fraction. The current priority is to understand which phenotypes of cardiac failure patients may benefit from treatment guiding individualised and personalised management.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Randerath, Winfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Deleanu, Oana Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiza, Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED Pepin, Jean-Louis UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133508
DOI:	10.1183/16000617.0084-2019
Journal or Publication Title:	Eur. Respir. Rev.
Volume:	28
Number:	153
Date:	2019
Publisher:	EUROPEAN RESPIRATORY SOC JOURNALS LTD
Place of Publication:	SHEFFIELD
ISSN:	1600-0617
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHEYNE-STOKES RESPIRATION; ADAPTIVE SERVO-VENTILATION; POSITIVE AIRWAY PRESSURE; SYMPATHETIC-NERVE ACTIVITY; NOCTURNAL OXYGEN-THERAPY; CARDIAC-FUNCTION; CARDIOVASCULAR OUTCOMES; CARBON-DIOXIDE; SERVOVENTILATION; HF Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13350