Universität zu Köln

Bruns, Christiane, Gebauer, Florian, Scheufele, Florian and Friess, Helmut (2019). Impact of surgery ofmetastases in advanced pancreatic cancer. Onkologe, 25 (8). S. 690 - 696. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

BackgroundAccording to the current guidelines surgery is not recommended in the metastasized stage of pancreatic cancer; however, in clinical practice surgery including resection of the primary tumor and metastases is performed in individual cases.AimThis review article summarizes the currently available evidence based on the published studies.Material and methodsAsystematic search in MEDLINE and PubMed was performed with respect to metastasized pancreatic cancer and surgical resection.ResultsThe evidence level is not sufficient to answer the question as to whether patients in an oligometastasized stage should be operated on or not. The available retrospective studies show atechnical feasibility of synchronous resection of the primary tumor and metastases with apossibly beneficial oncological outcome for specific patient groups.ConclusionBased on the currently available evidence, ageneral treatment decision for patients in an oligometastatic stage cannot be derived. Therefore, prospective clinical trials are necessary to answer the question of which patients could benefit from acombined resection of primary tumor and metastases embedded in amultimodal treatment concept.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebauer, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheufele, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Friess, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-133902
DOI:	10.1007/s00761-019-0547-8
Journal or Publication Title:	Onkologe
Volume:	25
Number:	8
Page Range:	S. 690 - 696
Date:	2019
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPH-NODE METASTASIS; SURGICAL RESECTION; LIVER METASTASES; ADENOCARCINOMA; MULTICENTER; SURVIVAL; THERAPY; SAFETY Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13390