Universität zu Köln

Boese, Christoph Kolja, Lechler, Philipp, Frink, Michael, Hackl, Michael, Eysel, Peer and Ries, Christian (2019). Cost-analysis of inpatient and outpatient parenteral antimicrobial therapy in orthopaedics: A systematic literature review. World J. Clin. Cases, 7 (14). S. 1825 - 1837. PLEASANTON: BAISHIDENG PUBLISHING GROUP INC. ISSN 2307-8960

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Abstract

BACKGROUND Increasing numbers of total joint arthroplasties and consecutive revision surgery are associated with the risk of periprosthetic joint infections (PPJI). Treatment of PPJI is complex and associated with immense socio-economic burden. One treatment aspect is parenteral antiinfective therapy, which usually requires an inpatient setting [Inpatient parenteral antibiotic therapy (IPAT)]. An alternative is outpatient parenteral treatment [Outpatient parenteral antibiotic therapy (OPAT)]. To conduct a health economic cost-benefit analysis of OPAT, a detailed cost analysis of IPAT and OPAT is required. So far, there is a lack of knowledge on the health economic effects of IPAT and OPAT for PPJI. AIM To review an economic comparison of IPAT and OPAT. METHODS A systematic literature review was performed through Medline following the PRISMA guidelines. RESULTS Of 619 identified studies, 174 included information of interest and 21 studies were included for quantitative analysis of OPAT and IPAT costs. Except for one study, all showed relevant cost savings for OPAT compared to IPAT. Costs for IPAT were between 1.10 to 17.34 times higher than those for OPAT. CONCLUSION There are only few reports on OPAT for PPJI. Detailed analyses to support economic or dinical guidelines are therefore limited. There is good clinical evidence supporting economic benefits of OPAT, but more high quality studies are needed for PPJI.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boese, Christoph Kolja UNSPECIFIED UNSPECIFIED UNSPECIFIED Lechler, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Frink, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Hackl, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Eysel, Peer UNSPECIFIED UNSPECIFIED UNSPECIFIED Ries, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-134616
DOI:	10.12998/wjcc.v7.i14.1825
Journal or Publication Title:	World J. Clin. Cases
Volume:	7
Number:	14
Page Range:	S. 1825 - 1837
Date:	2019
Publisher:	BAISHIDENG PUBLISHING GROUP INC
Place of Publication:	PLEASANTON
ISSN:	2307-8960
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIBIOTIC-THERAPY; KNEE-ARTHROPLASTY; JOINT INFECTIONS; PATIENT SATISFACTION; UTILIZATION RATES; OPAT; HOME; MANAGEMENT; EFFICACY; HIP Multiple languages Medicine, General & Internal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13461