Universität zu Köln

Ou, Hui-Ling, Kim, Christine S., Uszkoreit, Simon, Wickstroem, Sara A. and Schumacher, Bjoern (2019). Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. Dev. Cell, 50 (2). S. 167 - 192. CAMBRIDGE: CELL PRESS. ISSN 1878-1551

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Abstract

Genome integrity in primordial germ cells (PGCs) is a prerequisite for fertility and species maintenance. In C. elegans, PGCs require global-genome nucleotide excision repair (GG-NER) to remove UV-induced DNA lesions. Failure to remove the lesions leads to the activation of the C. elegans p53, CEP-1, resulting in mitotic arrest of the PGCs. We show that the eIF4E2 translation initiation factor IFE-4 in somatic gonad precursor (SGP) niche cells regulates the CEP-1/p53-mediated DNA damage response (DDR) in PGCs. We determine that the IFE-4 translation target EGL-15/FGFR regulates the non-cell-autonomous DDR that is mediated via FGF-like signaling. Using hair follicle stem cells as a paradigm, we demonstrate that the eIF4E2-mediated niche cell regulation of the p53 response in stem cells is highly conserved in mammals. We thus reveal that the somatic niche regulates the CEP-1/p53-mediated DNA damage checkpoint in PGCs. Our data suggest that the somatic niche impacts the stability of heritable genomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ou, Hui-Ling UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Christine S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Uszkoreit, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickstroem, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-134869
DOI:	10.1016/j.devcel.2019.06.012
Journal or Publication Title:	Dev. Cell
Volume:	50
Number:	2
Page Range:	S. 167 - 192
Date:	2019
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1878-1551
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEOTIDE EXCISION-REPAIR; CAENORHABDITIS-ELEGANS; INDUCED APOPTOSIS; PROTEIN-SYNTHESIS; TRANSLATIONAL CONTROL; MESSENGER-RNAS; STEM-CELLS; P53; GROWTH; INITIATION Multiple languages Cell Biology; Developmental Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13486