Bischof, Gerard N. and Jacobs, Heidi I. L. (2019). Subthreshold amyloid and its biological and clinical meaning Long way ahead. Neurology, 93 (2). S. 72 - 80. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1526-632X
Full text not available from this repository.Abstract
The development of in vivo imaging of the pathologic hallmark of Alzheimer disease (AD), beta-amyloid (A beta), altered the framing of its pathophysiology and formulation of inclusion criteria for clinical trials. Recent evidence suggests that in vivo measures of A beta deposition below a threshold indicative of A beta positivity carry critical information on future cognitive decline and accumulation of AD pathology, potentially already at a younger age. Here, we integrate the existing literature on histopathology of A beta and its convergence and divergence with in vivo A beta imaging. The evidence presented amounts to a reconceptualization, in which we advocate for a closer look into A beta accumulation rates in earlier life, the factors that promote accumulation, comparative studies with different markers of A beta, and longitudinal designs to elucidate when AD pathology rises and how it shifts from benign to malignant stages that ultimately define AD. These efforts open a new window of opportunity for disease-modifying interventions.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-135287 | ||||||||||||
DOI: | 10.1212/WNL.0000000000007747 | ||||||||||||
Journal or Publication Title: | Neurology | ||||||||||||
Volume: | 93 | ||||||||||||
Number: | 2 | ||||||||||||
Page Range: | S. 72 - 80 | ||||||||||||
Date: | 2019 | ||||||||||||
Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||||||||||
Place of Publication: | PHILADELPHIA | ||||||||||||
ISSN: | 1526-632X | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/13528 |
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