Universität zu Köln

Neefs, J., Boekholdt, S. M., Khaw, K-T, Luben, R., Pfister, R., Wareham, N. J., Meulendijks, E. R., Sanders, R. and de Groot, J. R. (2019). Body mass index and body fat distribution and new-onset atrial fibrillation: Substudy of the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study. Nutr. Metab. Carbiovasc. Dis., 29 (7). S. 692 - 701. OXFORD: ELSEVIER SCI LTD. ISSN 1590-3729

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Abstract

Background and aim: Obesity is a recognized risk factor for new-onset atrial fibrillation (AF). The association between body fat distribution, which is measured by body mass index (BMI) and waist-hip ratio (WHR), its changes, and new-onset AF is conflicting. Methods and results: Participants of the European Prospective Investigation into Cancer and Nutrition in Norfolk cohort study were included, with exclusion criteria of prevalent AF, rheumatic heart disease, and cancer. AF was confirmed by the International Classification of Diseases-10 hospital discharge code I48. Adjusted sex-specific Cox proportional hazards models were used to quantify the AF risk per 1 standard deviation increase and for quintiles of adiposity indices. A total of 10,885 men and 12,857 women were followed up for a median of 19 years, yielding 451,098 person-years. New-onset AF was diagnosed in 1408 (12.9%) men and 1102 (8.6%) women. Multivariable analyses showed that BMI predicted new-onset AF in all, while WHR predicted only in men. New-onset AF risk gradually increased across the range of adiposity indices: for men in the highest BMI quintile, HR: 1.59 (CI 1.32-1.91, p for trend<0.001), whereas for women in the highest BMI quintile, HR: 1.52 (CI 1.23-1.88, p for trend<0.001). Further, for men in the highest WHR quintile, HR: 1.31 (CI 1.09-1.57, p for trend: 0.01), whereas for women in the highest WHR quintile, HR: 1.12 (CI 0.90-1.41, p for trend: 0.17). The change in BMI and WHR was similar in participants with or without new-onset AF. Conclusions: An increased body mass, as measured by BMI, is associated with an increased risk of developing new-onset AF. More abdominal fat distribution, as measured by WHR, is associated with an increased risk of developing new-onset AF in men but not in women. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neefs, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boekholdt, S. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Khaw, K-T UNSPECIFIED UNSPECIFIED UNSPECIFIED Luben, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wareham, N. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meulendijks, E. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanders, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Groot, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-136887
DOI:	10.1016/j.numecd.2019.03.005
Journal or Publication Title:	Nutr. Metab. Carbiovasc. Dis.
Volume:	29
Number:	7
Page Range:	S. 692 - 701
Date:	2019
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1590-3729
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RISK-FACTOR; OBESITY; MANAGEMENT; OVERWEIGHT; REDUCTION; COHORT Multiple languages Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13688