Elhai, Muriel ORCID: 0000-0001-8627-5758, Boubaya, Marouane, Distler, Oliver ORCID: 0000-0002-0546-8310, Smith, Vanessa, Matucci-Cerinic, Marco, Alegre Sancho, Juan Jose, Truchetet, Marie-Elise, Braun-Moscovici, Yolanda, Iannone, Florenzo ORCID: 0000-0003-0474-5344, Novikov, Pavel I., Lescoat, Alain, Siegert, Elise, Castellvi, Ivan ORCID: 0000-0002-5410-5807, Airo, Paolo, Vettori, Serena, De Langhe, Ellen, Hachulla, Eric, Erler, Anne, Ananieva, Lidia, Krusche, Martin, Lopez-Longo, F. J., Distler, Joerg H. W., Hunzelmann, Nicolas, Hoffmann-Vold, Anna-Maria, Riccieri, Valeria, Hsu, Vivien M., Pozzi, Maria R., Ancuta, Codrina, Rosato, Edoardo ORCID: 0000-0002-7417-8093, Mihai, Carina, Kuwana, Masataka, Saketkoo, Lesley Ann, Chizzolini, Carlo, Hesselstrand, Roger, Ullman, Susanne, Yavuz, Sule, Rednic, Simona, Caimmi, Cristian, Bloch-Queyrat, Coralie, Allanore, Yannick, Guiducci, Serena ORCID: 0000-0003-2722-6475, Walker, Ulrich A., Kyburz, Diego, Lapadula, Giovanni, Maurer, Britta, Jordan, Suzana, Dobrota, Rucsandra, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Sulli, Alberto, Cutolo, Maurizio, Cuomo, Giovanna, Nicoara, Ileana, Kahan, Andre, Vlachoyiannopoulos, Panayiotis G., Montecucco, Carlo Maurizio, Caporali, Roberto, Stork, Jiri ORCID: 0000-0002-8505-3560, Inanc, Murat, Carreira, Patricia E., Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia ORCID: 0000-0002-6849-9114, Kucharz, Eugene J., Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Wollheim, Frank, Scheja, Agneta, Wuttge, Dirk M., Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Trotta, F., Lo Monaco, Andrea, Pellerito, Raffaele, Mauriziano, Ospedale, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Denton, Christopher, Damjanov, Nemanja, Henes, Jorg, Santamaria, Vera Ortiz, Heitmann, Stefan, Krasowska, Dorota, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Da Silva, Jose Antonio Pereira, Salvador, Maria Joao, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Tikly, Mohammed, Denisov, Lev N., Herrick, Ariane, Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriela, Mendoza, Antonio Zea, de la Puente, Carlos, Giraldo, Sifuentes W. A., Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Launay, David, Valesini, Guido, Ionescu, Ruxandra Maria, Groseanu, Laura, Opris, Daniela, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Milicescu, Mihaela, Sunderkotter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Melsens, Karin, Cantatore, Francesco P., Corrado, Ada, Iversen, Line, von Muhlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Eyerich, Kilian, Hein, Rudiger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A., Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Gunther, Claudia, Westhovens, Rene, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Granel, Brigitte, Muller, Carolina de Souza, Radominski, Sebastiao C., Azevedo, Valderilio F., Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D., Yoshinari, Natalino H., Marangoni, Roberta G., Martin, Patricia, Fuocco, Luiza, Stebbings, Simon, Highton, John, Chapman, Peter, O'Donnell, John, Stamp, Lisa, Doube, Alan, Solanki, Kamal, Veale, Douglas ORCID: 0000-0003-2802-4971, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario ORCID: 0000-0002-7301-8362, Chirieac, Rodica, Furst, Daniel, Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Fathi, Nihal, Hassanien, Manal, Lefebvre, Paloma Garcia de la Pena, Rubio, Silvia Rodriguez, Exposito, Marta Valero, Chatelus, Emmanuel, Sibilia, Jean, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Lasky, Joseph A., Cosentino, Vanesa, Kerzberg, Eduardo, Montoya, Fabiana, Bianchi, Washington, Carneiro, Sueli, Maretti, Giselle Baptista, Bianchi, Dante Valdetaro, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Kahl, Sarah, Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Martin, Thierry, Guffroy, Aurelien, Poindron, Vincent, Chotchaeva, Fatima, Mukhin, Nikolay A. and Moiseev, Sergey ORCID: 0000-0002-7232-4640
(2019).
Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study.
Ann. Rheum. Dis., 78 (7).
S. 979 - 988.
LONDON:
BMJ PUBLISHING GROUP.
ISSN 1468-2060
Full text not available from this repository.
Abstract
Objective To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice. Methods We performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab. Results 254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47-5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55-1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56-3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83-9.62]; p=0.019 as compared with controls vs 3 [0.66-5.35]; p=0.012). Conclusion Rituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.
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Journal Article
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Elhai, Muriel | UNSPECIFIED | orcid.org/0000-0001-8627-5758 | UNSPECIFIED | Boubaya, Marouane | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Distler, Oliver | UNSPECIFIED | orcid.org/0000-0002-0546-8310 | UNSPECIFIED | Smith, Vanessa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Matucci-Cerinic, Marco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Alegre Sancho, Juan Jose | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Truchetet, Marie-Elise | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Braun-Moscovici, Yolanda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Iannone, Florenzo | UNSPECIFIED | orcid.org/0000-0003-0474-5344 | UNSPECIFIED | Novikov, Pavel I. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lescoat, Alain | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Siegert, Elise | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Castellvi, Ivan | UNSPECIFIED | orcid.org/0000-0002-5410-5807 | UNSPECIFIED | Airo, Paolo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vettori, Serena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | De Langhe, Ellen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hachulla, Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Erler, Anne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ananieva, Lidia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Krusche, Martin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lopez-Longo, F. J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Distler, Joerg H. 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UNSPECIFIED | UNSPECIFIED | Kuhn, Annegret | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sandorfi, Nora | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schett, Georg | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beyer, Christian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meroni, Pierluigi | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ingegnoli, Francesca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mouthon, Luc | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | De Keyser, Filip | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Melsens, Karin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cantatore, Francesco P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Corrado, Ada | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Iversen, Line | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | von Muhlen, Carlos Alberto | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bohn, Jussara Marilu | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lonzetti, Lilian Scussel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eyerich, Kilian | UNSPECIFIED | UNSPECIFIED 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Miroslav | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Uprus, Maria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Otsa, Kati | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Granel, Brigitte | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muller, Carolina de Souza | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Radominski, Sebastiao C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Azevedo, Valderilio F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jimenez, Sergio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Busquets, Joanna | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Agachi, Svetlana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Groppa, Liliana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chiaburu, Lealea | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Russu, Eugen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Popa, Sergei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zenone, Thierry | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pileckyte, Margarita | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mathieu, Alessandro | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vacca, Alessandra | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sampaio-Barros, Percival D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yoshinari, Natalino H. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Marangoni, Roberta G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martin, Patricia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fuocco, Luiza | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stebbings, Simon | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Highton, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chapman, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | O'Donnell, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stamp, Lisa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Doube, Alan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Solanki, Kamal | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Veale, Douglas | UNSPECIFIED | orcid.org/0000-0003-2802-4971 | UNSPECIFIED | O'Rourke, Marie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Loyo, Esthela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Li, Mengtao | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mohamed, Walid Ahmed Abdel Atty | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Amoroso, Antonio | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gigante, Antonietta | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Oksel, Fahrettin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yargucu, Figen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tanaseanu, Cristina-Mihaela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Popescu, Monica | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dumitrascu, Alina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tiglea, Isabela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Foti, Rosario | UNSPECIFIED | orcid.org/0000-0002-7301-8362 | UNSPECIFIED | Chirieac, Rodica | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Furst, Daniel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Villiger, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Adler, Sabine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van Laar, Jacob | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kayser, Cristiane | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fathi, Nihal | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hassanien, Manal | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lefebvre, Paloma Garcia de la Pena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rubio, Silvia Rodriguez | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Exposito, Marta Valero | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chatelus, Emmanuel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sibilia, Jean | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gottenberg, Jacques Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chifflot, Helene | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Litinsky, Ira | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Emery, Paul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Buch, Maya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Del Galdo, Francesco | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Venalis, Algirdas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Butrimiene, Irena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Venalis, Paulius | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rugiene, Rita | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Karpec, Diana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lasky, Joseph A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cosentino, Vanesa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kerzberg, Eduardo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Montoya, Fabiana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bianchi, Washington | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Carneiro, Sueli | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Maretti, Giselle Baptista | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bianchi, Dante Valdetaro | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Limonta, Massimiliano | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brucato, Antonio Luca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lupi, Elide | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rosner, Itzhak | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rozenbaum, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Slobodin, Gleb | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Boulman, Nina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rimar, Doron | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Couto, Maura | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kahl, Sarah | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chen, Fei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | McCloskey, Deborah | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Malveaux, Halina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Spertini, Francois | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ribi, Camillo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Buss, Guillaume | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Martin, Thierry | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guffroy, Aurelien | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Poindron, Vincent | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chotchaeva, Fatima | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mukhin, Nikolay A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Moiseev, Sergey | UNSPECIFIED | orcid.org/0000-0002-7232-4640 | UNSPECIFIED |
|
URN: |
urn:nbn:de:hbz:38-136994 |
DOI: |
10.1136/annrheumdis-2018-214816 |
Journal or Publication Title: |
Ann. Rheum. Dis. |
Volume: |
78 |
Number: |
7 |
Page Range: |
S. 979 - 988 |
Date: |
2019 |
Publisher: |
BMJ PUBLISHING GROUP |
Place of Publication: |
LONDON |
ISSN: |
1468-2060 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
---|
EULAR SCLERODERMA TRIALS; B-CELL DEPLETION; SKIN INVOLVEMENT; RISK-FACTORS; THERAPY; IMPROVEMENT; PREDICTION; EXPERIENCE; MORTALITY; FIBROSIS | Multiple languages | Rheumatology | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/13699 |
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