Universität zu Köln

Braun, Fabian ORCID: 0000-0002-4742-050X, Suarez, Victor, Dinter, Johanna, Haneder, Stefan, Quaas, Alexander, Benzing, Thomas, Nierhoff, Dirk and Mueller, Roman-Ulrich (2019). Successful use of TNF alpha blockade in a severe case of idiopathic non-granulomatous ulcerative jejunoileitis associated with thrombotic thrombocytopenic purpura. BMJ Open Gastroenterol., 6 (1). LONDON: BMJ PUBLISHING GROUP. ISSN 2054-4774

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Abstract

We describe the case of 50-year-old female patient who presented with severe gastrointestinal symptoms and progressive weight loss of unknown origin. Shortly after admission, she developed an acute flare of thrombotic thrombocytopaenic purpura (TTP) that had to be treated by plasma exchange therapy and rituximab administration. While the signs of TTP subsided, the gastrointestinal symptoms worsened with abdominal cramps, massive gastric retention, malnourishment and a stenosis due to extensive inflammation and wall thickening of the small bowel. Extensive diagnostic efforts yielded no specific cause, so the patient-based on the histopathological findings-was diagnosed with idiopathic non-granulomatous ulcerative jejunoileitis. Following a highly complicated clinical course over several months, successful remission of the inflammatory activity and recovery of the patient could be obtained by TNF-alpha blockade.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Braun, Fabian UNSPECIFIED orcid.org/0000-0002-4742-050X UNSPECIFIED Suarez, Victor UNSPECIFIED UNSPECIFIED UNSPECIFIED Dinter, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Nierhoff, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Roman-Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-138741
DOI:	10.1136/bmjgast-2018-000252
Journal or Publication Title:	BMJ Open Gastroenterol.
Volume:	6
Number:	1
Date:	2019
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2054-4774
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RISK Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/13874