Jachimowicz, Ron D. and Reinhardt, H. Christian (2019). UBQLN4 promotes non-homologous end joining by repressing DNA end-resection. MOL. CELL ONCOL., 6 (2). PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2372-3548
Full text not available from this repository.Abstract
Ataxia-telangiectasia-mutated (ATM) promotes homologous recombination (HR)-mediated DNA double strand break repair. It was recently shown that the proteasomal shuttle factor UBQLN4 facilitates MRE11 degradation to repress HR. Surprisingly, the UBQLN4-MRE11 interaction is ATM-dependent, suggesting that the proximal DNA damage kinase ATM does not only initiate HR, but also limits excessive end resection.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-138858 | ||||||||||||
DOI: | 10.1080/23723556.2019.1575692 | ||||||||||||
Journal or Publication Title: | MOL. CELL ONCOL. | ||||||||||||
Volume: | 6 | ||||||||||||
Number: | 2 | ||||||||||||
Date: | 2019 | ||||||||||||
Publisher: | TAYLOR & FRANCIS INC | ||||||||||||
Place of Publication: | PHILADELPHIA | ||||||||||||
ISSN: | 2372-3548 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
Uncontrolled Keywords: |
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/13885 |
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