Universität zu Köln

Cirillo, Melita, Reinke, Sarah, Klapper, Wolfram and Borchmann, Sven (2019). The translational science of hodgkin lymphoma. Br. J. Haematol., 184 (1). S. 30 - 45. HOBOKEN: WILEY. ISSN 1365-2141

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Abstract

Hodgkin Lymphoma (HL) is an unusual B-cell lymphoma because the malignant cells exist as a minority population in a densely cellular microenvironment. The microenvironment is comprised predominately of inflammatory and immune cells with fibrosis in some cases. There are multiple dysregulated signalling pathways that sustain HL within this microenvironment, such as the Nuclear factor-kappa B and Janus kinase/signal transducers and activators of transcription pathways. Advances in genomic medicine have enabled a better characterisation of the rare tumour cells and improved our understanding of the signalling mechanisms that exist between the malignant cell and its microenvironment. Current therapy for HL produces excellent clinical outcomes in most younger patients. However, problems with current treatment approaches include poorer outcomes in the elderly, toxicity of highly-effective combination chemotherapy regimens and relapse in high-risk patients. Better understanding of disease biology aids in upfront prognostication of patients, defines new methods for treatment monitoring and assists in the recognition of novel targets for therapy. Biology-driven therapies, including anti-CD30 antibody conjugates, cellular immunotherapies and immune modulation, particularly with checkpoint inhibitors, have changed treatment algorithms for relapsed/refractory patients. Future challenges exist in incorporating immune-based therapies earlier in treatment algorithms to reduce toxicity and prevent relapse for patients with HL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cirillo, Melita UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinke, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Klapper, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140566
DOI:	10.1111/bjh.15658
Journal or Publication Title:	Br. J. Haematol.
Volume:	184
Number:	1
Page Range:	S. 30 - 45
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REED-STERNBERG CELLS; TUMOR-ASSOCIATED MACROPHAGES; REGULATORY T-CELLS; BRENTUXIMAB VEDOTIN; PHASE-II; PROGNOSTIC IMPACT; IMMUNE EVASION; NK CELLS; RECURRENT; DISEASE Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14056