Universität zu Köln

Boell, Boris and Goergen, Helen (2019). The treatment of older Hodgkin lymphoma patients. Br. J. Haematol., 184 (1). S. 82 - 93. HOBOKEN: WILEY. ISSN 1365-2141

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Abstract

The outcome of patients with Hodgkin lymphoma (HL) has dramatically improved over the past decades and continues to improve with the development of novel targeted therapies, such as the immunoconjugate brentuximab vedotin and the checkpoint inhibitors nivolumab and pembrolizumab. Moreover, with the use of response-adapted strategies using positron-emission-tomography (PET), the overall intensity of treatment for most patients can be reduced, resulting in less acute and late toxicity. However, these advances are mainly restricted to younger patients, as advances in patients above the age of 60 years ('older' patients) have been much less pronounced. Furthermore, about one third of all HL patients are among the older population, but only 5-10% of the patients treated in current HL clinical trials are >= 60 years old. HL in older patients is characterized by aggressive disease and unfavourable prognostic features as B symptoms and predominance of advanced stages. In addition, tolerance to curative chemotherapy is drastically reduced in older patients resulting in excessive toxicity and insufficient treatment due to therapy delays and dose reductions. Therefore, there is a significant unmet medical need in older HL patients for less toxic and effective therapies, and an important gap of knowledge concerning this growing population of patients. Recent advances on epidemiology, characteristics and treatment of older HL patients will be summarized in this article.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boell, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Goergen, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140574
DOI:	10.1111/bjh.15652
Journal or Publication Title:	Br. J. Haematol.
Volume:	184
Number:	1
Page Range:	S. 82 - 93
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; STUDY-GROUP GHSG; ELDERLY-PATIENTS; BRENTUXIMAB VEDOTIN; PHASE-II; COMPREHENSIVE ANALYSIS; ADAPTED TREATMENT; RANDOMIZED-TRIAL; OPEN-LABEL Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14057