Universität zu Köln

Roehr, Susanne ORCID: 0000-0001-9385-0669, Riedel-Heller, Steffi G., Kaduszkiewicz, Hanna, Wagner, Michael ORCID: 0000-0003-2589-6440, Fuchs, Angela, van der Leeden, Carolin, Wiese, Birgitt, Werle, Jochen, Bickel, Horst, Koenig, Hans-Helmut, Wolfsgruber, Steffen, Pentzek, Michael, Weeg, Dagmar, Mamone, Silke, Weyerer, Siegfried, Brettschneider, Christian ORCID: 0000-0002-5280-1075, Maier, Wolfgang, Scherer, Martin, Jessen, Frank and Luck, Tobias ORCID: 0000-0001-7551-4397 (2019). Is function in instrumental activities of daily living a useful feature in predicting Alzheimer's disease dementia in subjective cognitive decline? Int. J. Geriatr. Psychiatr., 34 (1). S. 193 - 204. HOBOKEN: WILEY. ISSN 1099-1166

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Abstract

Objective Subjective cognitive decline (SCD), the earliest symptom in preclinical Alzheimer's disease (AD), is insufficient to identify individuals at risk for AD dementia. Therefore, we aimed to investigate whether function in instrumental activities of daily living (IADL) contributes to identification. Methods We analysed data of cognitively unimpaired participants of the prospective German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) and its extension, the Study on Needs, Health Service Use, Costs and Health-related Quality of Life in a Large Sample of Oldest-old Primary Care Patients (AgeQualiDe), collected over 10.5 years. Development of AD dementia was quantified as incidence rates (IRs) per 1000 person-years. Cox regression was used to assess the association of SCD and IADL function in regard to incident AD dementia. Results Of 1467 included individuals, 792 (54.0%) reported SCD at baseline. Impaired IADL were present in 50 (3.4%) individuals. IR for AD dementia was highest in individuals with SCD and impaired IADL (49.7; 95% CI, 24.8-99.3). Unadjusted and adjusted Cox analyses revealed an increased AD dementia risk for individuals with SCD and impaired IADL (uHR = 6.1; 95% CI, 2.9-13.0; P < 0.001; aHR = 2.5; 95% CI, 1.1-5.7; P < 0.05). Conclusions Consistent with the SCD concept, IADL function was largely well preserved in the majority of individuals with SCD. However, if difficulties in IADL were present, risk for AD dementia was increased. Therefore, screening for IADL impairment could serve as an economically viable indicator to assess AD dementia risk above and beyond SCD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roehr, Susanne UNSPECIFIED orcid.org/0000-0001-9385-0669 UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaduszkiewicz, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Fuchs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Leeden, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiese, Birgitt UNSPECIFIED UNSPECIFIED UNSPECIFIED Werle, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickel, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Hans-Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Pentzek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Weeg, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Mamone, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Weyerer, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Brettschneider, Christian UNSPECIFIED orcid.org/0000-0002-5280-1075 UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Luck, Tobias UNSPECIFIED orcid.org/0000-0001-7551-4397 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140759
DOI:	10.1002/gps.5010
Journal or Publication Title:	Int. J. Geriatr. Psychiatr.
Volume:	34
Number:	1
Page Range:	S. 193 - 204
Date:	2019
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1099-1166
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OLDER-ADULTS; EXECUTIVE FUNCTION; MEMORY COMPLAINTS; LIFE-SPACE; IMPAIRMENT; DIAGNOSIS; SELF; HEALTH; SIDAM Multiple languages Geriatrics & Gerontology; Gerontology; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14075