Universität zu Köln

Jones, Graham R. D., Haeckel, Rainer, Loh, Tze Ping ORCID: 0000-0002-4272-0001, Sikaris, Ken, Streichert, Thomas, Katayev, Alex, Barth, Julian H. and Ozarda, Yesim (2019). Indirect methods for reference interval determination - review and recommendations. Clin. Chem. Lab. Med., 57 (1). S. 20 - 30. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1437-4331

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Abstract

Reference intervals are a vital part of the information supplied by clinical laboratories to support interpretation of numerical pathology results such as are produced in clinical chemistry and hematology laboratories. The traditional method for establishing reference intervals, known as the direct approach, is based on collecting samples from members of a preselected reference population, making the measurements and then determining the intervals. An alternative approach is to perform analysis of results generated as part of routine pathology testing and using appropriate statistical techniques to determine reference intervals. This is known as the indirect approach. This paper from a working group of the International Federation of Clinical Chemistry (IFCC) Committee on Reference Intervals and Decision Limits (C-RIDL) aims to summarize current thinking on indirect approaches to reference intervals. The indirect approach has some major potential advantages compared with direct methods. The processes are faster, cheaper and do not involve patient inconvenience, discomfort or the risks associated with generating new patient health information. Indirect methods also use the same preanalytical and analytical techniques used for patient management and can provide very large numbers for assessment. Limitations to the indirect methods include possible effects of diseased subpopulations on the derived interval. The IFCC C-RIDL aims to encourage the use of indirect methods to establish and verify reference intervals, to promote publication of such intervals with clear explanation of the process used and also to support the development of improved statistical techniques for these studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jones, Graham R. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeckel, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Loh, Tze Ping UNSPECIFIED orcid.org/0000-0002-4272-0001 UNSPECIFIED Sikaris, Ken UNSPECIFIED UNSPECIFIED UNSPECIFIED Streichert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Katayev, Alex UNSPECIFIED UNSPECIFIED UNSPECIFIED Barth, Julian H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ozarda, Yesim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-140894
DOI:	10.1515/cclm-2018-0073
Journal or Publication Title:	Clin. Chem. Lab. Med.
Volume:	57
Number:	1
Page Range:	S. 20 - 30
Date:	2019
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	1437-4331
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDIVIDUAL BIOLOGICAL VARIATION; DETERMINING REFERENCE LIMITS; REFERENCE VALUES; HOSPITALIZED POPULATION; GLOBAL MULTICENTER; DERIVATION; BHATTACHARYA; PROJECT; PAPER Multiple languages Medical Laboratory Technology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14089