Universität zu Köln

Herkenrath, S. D. and Randerath, W. J. (2019). Current insights in the pathophysiology of sleep disordered breathing. Somnologie, 23 (3). S. 164 - 172. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG. ISSN 1439-054X

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Abstract

Sleep-related breathing disturbances include obstructive and central sleep apnea as well as sleep-related hypoventilation syndromes. The underlying pathophysiological characteristics of these diseases essentially differ. While obstructive sleep apnea is primarily due to upper airway collapse, central sleep apnea is mainly driven by a disturbed ventilatory control. Increased respiratory mechanical load and/or an impaired neuronal signal transduction/muscle dystrophy promote the occurrence of a (sleep-related) hypoventilation. Usually we diagnose one of these entities based on polysomnographic und capnometric characteristics, but frequently a co-existence of different pathophysiological aspects can be found. This is especially true in the multi-morbid elderly patient. In order to define disease entities more clearly and develop sufficient therapy concepts, a differentiated appraisal of each and every underlying disturbance is needed. Only the integrative therapy approach oriented towards the underlying pathophysiology facilitates effective suppression of sleep-related breathing disturbances and ensures long-term therapy adherence. This article describes current pathophysiological concepts of sleep-related breathing disturbances and is intended to help develop integrative therapy strategies oriented towards pathophysiology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herkenrath, S. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Randerath, W. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-142686
DOI:	10.1007/s11818-019-00220-0
Journal or Publication Title:	Somnologie
Volume:	23
Number:	3
Page Range:	S. 164 - 172
Date:	2019
Publisher:	SPRINGER INTERNATIONAL PUBLISHING AG
Place of Publication:	CHAM
ISSN:	1439-054X
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OBESITY HYPOVENTILATION SYNDROME; UPPER AIRWAY COLLAPSIBILITY; FLOW LIMITATION; WEDGE PRESSURE; FLUID SHIFT; LOOP GAIN; APNEA; FAT; PATHOGENESIS; HYPERCAPNIA Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14268