Butter, Christian, Okamoto, Maki, Schymik, Gerhard, Jacobshagen, Claudius, Rothe, Juergen, Treede, Hendrik, Kerber, Sebastian, Frank, Derk, Bramlage, Peter, Sykorova, Lenka, Thoenes, Martin and Rudolph, Tanja K. (2019). Degree of valve calcification in patients undergoing transfemoral transcatheter aortic valve implantation with and without balloon aortic valvuloplasty: Findings from the multicenter EASE-IT TF registry. Catheter. Cardiovasc. Interv., 94 (3). S. 469 - 479. HOBOKEN: WILEY. ISSN 1522-726X

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Abstract

Aims We aimed to assess whether the level of aortic root calcification is associated with BAV performance/omission during transcatheter aortic valve implantation (TAVI), and to explore related outcomes. Methods and results EASE-IT TF was a prospective, observational, multicenter registry of patients undergoing TF-TAVI with the Edwards SAPIEN 3, with or without BAV predilation. Valvular calcification was quantified from pre-procedural multi-slice computed tomography images and compared between BAV and no BAV patients. Data for 178 patients (55 BAV; 123 no BAV) were analyzed. There were no significant differences between groups in terms of regional/leaflet sector calcification volumes, maximum asymmetry between the different leaflet sectors, or total calcification scores. Overall, a greater-than-average leaflet calcification volume was independently predictive of >= mild PVL (OR: 5.116; 95% CI: 1.042-38.35) and the need for post-dilation (OR: 3.592; 95% CI: 1.173-12.14). The latter effect was abated in patients with BAV (OR: 1.837; 95% CI: 0.223-18.00) and intensified in those without BAV (OR: 5.575; 95% CI: 1.114-38.74). No other BAV-dependent effects of calcification on outcomes were observed. Conclusions In the majority of transfemoral valve implantations, calcification does not appear to be the main driving factor in the decision to perform/omit BAV. Predilation may be valuable for reducing post-dilation requirements in patients only with a greater degree of leaflet calcification.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Butter, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okamoto, MakiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schymik, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobshagen, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothe, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Treede, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kerber, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frank, DerkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bramlage, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sykorova, LenkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thoenes, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rudolph, Tanja K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-142910
DOI: 10.1002/ccd.28164
Journal or Publication Title: Catheter. Cardiovasc. Interv.
Volume: 94
Number: 3
Page Range: S. 469 - 479
Date: 2019
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1522-726X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PARAVALVULAR LEAKAGE; POST-DILATION; CALCIUM QUANTIFICATION; SAPIEN 3; PREDILATION; IMPACT; REGURGITATION; FEASIBILITY; STENOSIS; SAFETYMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/14291

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