Universität zu Köln

Niether, Doreen and Wiegand, Simone ORCID: 0000-0001-6333-1956 (2019). Thermodiffusion and hydrolysis of 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). Eur. Phys. J. E, 42 (9). NEW YORK: SPRINGER. ISSN 1292-895X

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Abstract

Presently, microfluidic traps are designed mimicking the environment of hydrothermal pores, where a combination of thermophoresis and convection leads to accumulation so that high concentrations of organic matter can be reached. Such a setup is interesting in the context of the origin of life to observe accumulation and possible further synthesis of small organic molecules or prebiotic molecules such as nucleotides or RNA-fragments, but could also be used to replicate DNA-strands. The addition of coupling agents for the activation of carboxyl or phosphate groups such as 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and EDC-hydrochloride (EDC-HCl) is necessary in order to speed up the process. This work characterizes the thermophoretic properties of EDC and EDC-HCl needed to optimize the design of the traps. At p H 4-6 spontaneous hydrolysis of EDC is observed, which also leads to a neutralisation of the p H. In order to evaluate the thermodiffusion measurements the rate constants were measured at 23 and C and the activation energy of the hydrolysis calculated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Niether, Doreen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiegand, Simone UNSPECIFIED orcid.org/0000-0001-6333-1956 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-143030
DOI:	10.1140/epje/i2019-11880-1
Journal or Publication Title:	Eur. Phys. J. E
Volume:	42
Number:	9
Date:	2019
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1292-895X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Physical Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Polymer Science Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/14303